Protein Alignment spag4 and Sun2

DIOPT Version :10

• Sequence 1: NP_609510.2
• Gene: spag4 / 34581
• FlyBaseID: FBgn0032368
• Length: 275
• Species: Drosophila melanogaster
• Sequence 2: NP_001192274.1
• Gene: Sun2 / 223697
• MGIID: 2443011
• Length: 731
• Species: Mus musculus
• Alignment Length: 261
• Identity: 57/261 - (21%)
• Similarity: 124/261 - (47%)
• Gaps: 29/261 - (11%)

  Fly    22 SHILRQQQIDSKVAQGSCKFNCLGGEPKGVGSGMCNNRDVSAYVDTLFKRK--IGHLMDDVYNLK 84
            |.:|::.::.:::.:...|......|.:|..:     |:.:|.:..:.:::  :|...:.|:.:.
Mouse   487 SGLLQRDEMHAQLQELENKILTKMAEMQGKSA-----REAAASLGQILQKEGIVGVTEEQVHRIV 546

  Fly    85 KQVMSADCSSKSAQSTPKPESVALAKPRINYASEELGARIINVK-AHSIDGTNIIRSLLGLD--F 146
            ||.:......:...              ::||.|..||.:|:.: :.:.:....:.||.|:.  :
Mouse   547 KQALQRYSEDRIGM--------------VDYALESGGASVISTRCSETYETKTALLSLFGIPLWY 597

  Fly   147 STNPPVNMIRTGLSPGSCFGFNGSRATVTLHLARTIIVEAITLTHVAREMTPDLCVKSAPKNFDV 211
            .:..|..:::..:.||:|:.|.|.:....:.|:..|...|:||.||.:.::|:..:.||||:|.:
Mouse   598 HSQSPRVILQPDVHPGNCWAFQGPQGFAVVRLSARIRPTAVTLEHVPKALSPNSTISSAPKDFAI 662

  Fly   212 YGLRSENSKRE--LLGQWSYDNAANK-RTQSYSVRSDTFFRNLDFSFNSNHG-ANSTCIYRVEVY 272
            :|. .|:.::|  |||.::||..... :|..:.......::.::....:|.| ...|||||..|:
Mouse   663 FGF-DEDLQQEGTLLGTFAYDQDGEPIQTFYFQASKMATYQVVELRILTNWGHPEYTCIYRFRVH 726

  Fly   273 G 273
            |
Mouse   727 G 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spag4	NP_609510.2	Sad1_UNC	148..274	CDD:400199	37/130 (28%)
Sun2	NP_001192274.1	LMNA-binding	1..128
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..69
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	106..142
		COG4913	<252..>472	CDD:443941
		SUN2_cc1	414..468	CDD:410604
		HTH_SUN2	495..552	CDD:436594	9/61 (15%)
		Sufficient for interaction with SYNE1 and SYNE2. /evidence=ECO:0000250|UniProtKB:Q9UH99	521..731		51/222 (23%)
		Sad1_UNC	595..729	CDD:400199	37/134 (28%)