DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlg5 and CYTIP

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_004279.3	Gene:	CYTIP / 9595	HGNCID:	9506	Length:	359	Species:	Homo sapiens

Alignment Length:	397	Identity:	75/397 - (18%)
Similarity:	126/397 - (31%)	Gaps:	125/397 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   384 MAIRDSEKIKKQKD------EAQKKIDLLKEQMEQQERQNLDSNASGSRRSFRPSSYEGEDLLEV 442
            :.:.|:.:|:...|      ..:|::.|        .|.:..|:.|.|:|.......:..:....
Human    34 LTMDDNRRIQMLADTVATLPRGRKQLAL--------TRSSSLSDFSWSQRKLVTVEKQDNETFGF 90

  Fly   443 ELSGYEHTSDLGIILDDSNKRKLVCGVTSSSPA-CGKLKINDVICKVNNLDCQSLSKRMVLDEIR 506
            |:..|...:....   .|....|:|.:...||| |..|:..||:..:|.:..:..:.:.|:|.||
Human    91 EIQSYRPQNQNAC---SSEMFTLICKIQEDSPAHCAGLQAGDVLANINGVSTEGFTYKQVVDLIR 152

  Fly   507 ACAP-------RSLLLVSRTR-HSKRHAYSVQLKTRDRDCPHGLQLDMGVFIAKIEQNSLAFYEP 563
            :...       ...:::.||. .:|.......||.:                 .:|..||...|.
Human   153 SSGNLLTIETLNGTMILKRTELEAKLQVLKQTLKQK-----------------WVEYRSLQLQEH 200

  Fly   564 ELDVGDRVLSINNKSMDSVQSIEEVMQLMNDPRSDGLNLFALKYVQDQLP-PGMT---------- 617
            .|..||.....:.::||                .|.|:||.      .|| ||..
Human   201 RLLHGDAANCPSLENMD----------------LDELSLFG------PLPGPGPALVDRNRLSSE 243

  Fly   618 ------TSSAQTDSIDSMQHVSSAGGGGGSGPSSATKHPSRFAEFFFRKLKFSKPGTPEDN--FE 674
                  .||...||.|..|...|.....|:                     ||:..:.:|.  ..
Human   244 SSCKSWLSSMTMDSEDGYQTCVSEDSSRGA---------------------FSRQTSTDDECFIP 287

  Fly   675 QEHDDAIAALDSVLSENSSEKSKENLFNRKKRTKK---EKEASKSMGTWPRTNISHENPTGTMRG 736
            :|.||.:        ..||.:...::.|....:..   |...|...||.||.         :.:|
Human   288 KEGDDFL--------RRSSSRRNRSISNTSSGSMSPLWEGNLSSMFGTLPRK---------SRKG 335

  Fly   737 NEKKRAL 743
            :.:|:.|
Human   336 SVRKQLL 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007	5/29 (17%)
		PDZ_signaling	439..516	CDD:238492	17/84 (20%)
		PDZ_signaling	533..592	CDD:238492	9/58 (16%)
		PDZ_signaling	1290..1369	CDD:238492
		PDZ_signaling	1497..1576	CDD:238492
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
CYTIP	NP_004279.3	PDZ_signaling	76..161	CDD:238492	17/87 (20%)
CYTIP	NP_004279.3	Interaction with CYTH1	166..188		5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900