DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlg5 and SLC9A3R2

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	XP_016879383.1	Gene:	SLC9A3R2 / 9351	HGNCID:	11076	Length:	372	Species:	Homo sapiens

Alignment Length:	313	Identity:	73/313 - (23%)
Similarity:	110/313 - (35%)	Gaps:	70/313 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1376 PSIEYEGAHNLEPE--SPINHSGSPTPRNSPRPPARNSLFPLPMQPQAPSTRPGSRAPLSHQSIK 1438
            ||  :.|...|||.  |.::|..:|...::|..|      |:|.:|          .|
Human    87 PS--WVGGARLEPSQGSGLSHHPAPQSDSAPTSP------PIPGEP----------GP------- 126

  Fly  1439 DQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEP---KPSLPP--PP----ASVPA 1494
             |...|..........|...|.....|....|:..:......|   .|..||  ||    .|.|.
Human   127 -QREVDKWGGSLGRPESSGHPGRTPATCCHCAAVMARSGSATPPARAPGAPPRSPPQRLDVSGPL 190

  Fly  1495 ETLRYVTLHMDKS-KNLGIKLFGG-NKVGIYVHDVAVGSPSDHAGIRKGDQILEYNGVDLSGVTA 1557
            ..||....|:.|. :..|..|... ::.|.|:..|..|||:..:|:|..|:::|.||.::.|:..
Human   191 RELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRH 255

  Fly  1558 EQAANEISKLTDTVTMLVQNKLHTLKQIKDEPGDSFYIRVGFDRTGELNEDDLRFVKDEVLYVDN 1622
            .:....|....|...:||          .|...|..:.|:....|.|..|..|          .:
Human   256 AEVVASIKAREDEARLLV----------VDPETDEHFKRLRVTPTEEHVEGPL----------PS 300

  Fly  1623 TVFNGTF------GLWRAWKLDAMGHRK---ECG--IIPSQMKVEEELRSGEV 1664
            .|.|||.      |...:.:.|..|..|   |.|  :.|:..:.:|:.|:..|
Human   301 PVTNGTSPAQLNGGSACSSRSDLPGSDKDTEESGLHLSPTAAEAKEKARAMRV 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492
		PDZ_signaling	1497..1576	CDD:238492	22/80 (28%)
		SH3_DLG5	1594..1657	CDD:212794	16/73 (22%)
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
SLC9A3R2	XP_016879383.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810