DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and DLG5

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_004738.3	Gene:	DLG5 / 9231	HGNCID:	2904	Length:	1919	Species:	Homo sapiens

Alignment Length:	2039	Identity:	532/2039 - (26%)
Similarity:	852/2039 - (41%)	Gaps:	508/2039 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 NYDILQAQYKSALLELNTLRHQHANTKRRCDELATELTLY---QEHYVADRNKFTDMVEESAR-- 131
            :|:.|:.|...|:.:|.:|::||.|..:||:|:|.|...|   ....::|:.:..|.|:...|
Human   187 DYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTRLKDDVDMLRREN 251

  Fly   132 ----------------FKRLLLETQNQ----QSQQAQ----NGNSQVPPVGSGNPYYFGKTQGCD 172
                            .|||..|.|.:    ::||.|    ||:|::.     |..|
Human   252 GQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEIL-----NKLY-------- 303

  Fly   173 GSCSEKLAELKKERNMVAVEREKYKKSYIELEKDRNYYRERGDENQKL---KVLLSQESKNVLSL 234
            .:..:||..:||:.:.:   |::|.:.......|.:...:.|:|||:|   ..:|:|:....:.|
Human   304 DTAMDKLEVVKKDYDAL---RKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQRDTAIQL 365

  Fly   235 T--------------EELNQLLSEKDNVLQEHQKMSDDL-------VLANKEIERLKKDEQLARA 278
            .              .|||:..::..::..|.:.:..:|       |...||.|:.:::.....:
Human   366 QHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYS 430

  Fly   279 EIKVL------------------QLANADLKKRDLLKSRDSSWSKEFPSGKELE----------- 314
            |.|::                  :||.:.||         ||.|::..:.:|:|
Human   431 EYKLIMSERDQVISELDKLQTEVELAESKLK---------SSTSEKKAANEEMEALRQIKDTVTM 486

  Fly   315 ----NSKELEKLRKSLEKALSEVERSSQDAEEAKRVRDWAISQREKIVQERDSVKTLCDKMRHER 375
                .:||:|.|||..:....|::.:.|:|:.||..||||..:|:|||.||||::||||.:|.||
Human   487 DAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRER 551

  Fly   376 DKAISDSLMAIRDSEKIKKQKDEAQKKIDLLKEQMEQQERQNLDSNASGSRRSFRPSSYEG---E 437
            |:|:|:...|:|..:..:|||::..:::..||||||.|    |:..|. .|:....||::.   .
Human   552 DRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMESQ----LEKEAR-FRQLMAHSSHDSAIDT 611

  Fly   438 DLLEVELSGYE---HTSD-----LGIILDDSNKRKLV---CG-----VTSSSPACGKLKINDVIC 486
            |.:|.|....|   .|.|     ||..:.:.......   ||     |...|.|.|:|::||.:.
Human   612 DSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIADGRLRVNDWLL 676

  Fly   487 KVNNLDCQSLSKRMVLDEIRACAPRSLL-------LVSRTRHSKRHAYSVQLK---TRDRDCPHG 541
            ::|::|..:..|:..:        ::||       :|.|.|.|........|.   :..:|  .|
Human   677 RINDVDLINKDKKQAI--------KALLNGEGAINMVVRRRKSLGGKVVTPLHINLSGQKD--SG 731

  Fly   542 LQLDMGVFIAKIEQNSLAFYEPELDVGDRVLSINNKSMDSVQSIEEVMQLMNDPRSDGLNLFALK 606
            :.|:.||:.|.:...|.|..|..|.||||:::||..::|: :|:.|...|:...: |.|.|..||
Human   732 ISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDN-KSLNECESLLRSCQ-DSLTLSLLK 794

  Fly   607 -YVQDQLPPGMT--------------------------------TSSAQTDSI--DSMQHVSSAG 636
             :.|.....|..                                .:|.|||..  |.::.....|
Human   795 VFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNNSTQTDIFYTDRLEDRKEPG 859

  Fly   637 GGGGSGPSSATKHPSRFAEFFFRKLKFSKPGTPEDNFEQEHDDAI-AALDSVLSENSSEKSKENL 700
            ..|||  ||....|.              ||.|.....|....|. .:|.|..|:.|.::....:
Human   860 PPGGS--SSFLHKPF--------------PGGPLQVCPQACPSASERSLSSFRSDASGDRGFGLV 908

  Fly   701 FNRKKR-------------------TKKEKEASKSMGTWPRTNISHENPTGTMRGNEKKRALMSL 746
            ..|.:|                   .|.:.|.|.|.||||:..:|.......:...:|.:...|:
Human   909 DVRGRRPLLPFETEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEKLSVYKKPKQRKSI 973

  Fly   747 FTAGPINVDKDDELMGEVGVPEKQPAALIQDQLPPPLPPQMSKPLAHIRGSNGGAIKTHPNRNSN 811
            |                      .|....:.|.||.:...:..|        |.|....|::.:.
Human   974 F----------------------DPNTFKRPQTPPKIDYLLPGP--------GPAHSPQPSKRAG 1008

  Fly   812 PVSSGVSALFPPGPPNGMPNTSYPTHPRHSLYGVTAEEINQKPIQRAPLMGANARVKMPSQERYG 876
            |       |.||.||....:..:    :|.|  .|:.|      ..|.|:|::.....||.
Human  1009 P-------LTPPKPPRRSDSIKF----QHRL--ETSSE------SEATLVGSSPSTSPPSA---- 1050

  Fly   877 TRPHSNHRLSLNITPSGDFYQPKTSGQQAQQQVMNASSTSAGFGVGSGSMVGGTGPAAGEFPVRK 941
                        :.|..|..:|..:....:.:|..|||.   :..|.|.        :...|.:|
Human  1051 ------------LPPDVDPGEPMHASPPRKARVRIASSY---YPEGDGD--------SSHLPAKK 1092

  Fly   942 --------QQVYDVFHPPPLPKNSSGSNMFMPLHPTRGSHPPPVGQPPDVVSLKSQNSIESILSA 998
                    |:|.::......||::          |:......||..|...  |:.|..:.: ...
Human  1093 SCDEDLTSQKVDELGQKRRRPKSA----------PSFRPKLAPVVIPAQF--LEEQKCVPA-SGE 1144

  Fly   999 KSPAISEYGMYAKRHVPQAVRH--VPKYPSDSESIGSGVHGGYGGFLQSNHMPGNRHTQLFPTFG 1061
            .||.:.|:..|:..|   :.||  .|.||| ..|:|:...........|:.:....:|......|
Human  1145 LSPELQEWAPYSPGH---SSRHSNPPLYPS-RPSVGTVPRSLTPSTTVSSILRNPIYTVRSHRVG 1205

  Fly  1062 PGGRGNRRSSPLTLPSPPPQQQLQQLPAATAPHDSVGIPTDLDYHPHHHTQTNAMPHPHPHPHAP 1126
            |      .|||.......||          ..|.||.....|.....|.|.:
Human  1206 P------CSSPPAARDAGPQ----------GLHPSVQHQGRLSLDLSHRTCS------------- 1241

  Fly  1127 YLDYGHGLGIGPYMGVGGGVSGVGGAIYEGGTFPRKKDNQRLRIPSNPSVASKSSSMVKNSSGSI 1191
              ||..       |....|.:.:..:...|.:...:...:|::|||.|..   ..|:|.:..||:
Human  1242 --DYSE-------MRATHGSNSLPSSARLGSSSNLQFKAERIKIPSTPRY---PRSVVGSERGSV 1294

  Fly  1192 DHHYVTSTGPVSGGSMSASSSDRAPMSL--MSSSIHNSYGANIAGGNGTGSSIGVGGGGGGGSGR 1254
            .|             ...|:..::|:::  :||...:...|
Human  1295 SH-------------SECSTPPQSPLNIDTLSSCSQSQTSA------------------------ 1322

  Fly  1255 GSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRVTIDKRDKSLGITIQCNNNGGGIFVST 1319
             |.:|::.|...|     .|:|..:.|    ...:.|.|.:.|..:.|||:| .:...|||:||.
Human  1323 -STLPRIAVNPAS-----LGERRKDRP----YVEEPRHVKVQKGSEPLGISI-VSGEKGGIYVSK 1376

  Fly  1320 VADKSTAMRAGLQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLVQYNP--EKFPSIEYEG 1382
            |...|.|.:|||:.||||||..|||:|:||::.|..::.|..|:.|:|.||||  .:..|.....
Human  1377 VTVGSIAHQAGLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRSS 1441

  Fly  1383 AHNLEP---ESPINHSGSPTPRNSPRPPARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTD 1444
            :| |:|   .|.:..||:.||.:.      :.:.||..|.:.|||.|..:
Human  1442 SH-LDPAGTHSTLQGSGTTTPEHP------SVIDPLMEQDEGPSTPPAKQ--------------- 1484

  Fly  1445 SLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSLPPPPASVPAETLRYVTLHMDKSKN 1509
                                       ::|.:..:..|.:|.|....:....|           .
Human  1485 ---------------------------SSSRIAGDANKKTLEPRVVFIKKSQL-----------E 1511

  Fly  1510 LGIKLFGGNKVGIYVHDVAVGSPSDHA-GIRKGDQILEYNGVDLSGVTAEQAANEISKLTDTVTM 1573
            ||:.|.|||..|::|.:|...||:... |:..||.||||..:|:...|.|:...|:.|..|.|.:
Human  1512 LGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEVYVEMLKPRDGVRL 1576

  Fly  1574 LVQNKLHTLKQIKDEPGDSFYIRVGFDRTGELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLD 1638
            .||.:.....:.|..||||||||..:||..:: |.:|.|.||::||||:|:..||||.|.||:||
Human  1577 KVQYRPEEFTKAKGLPGDSFYIRALYDRLADV-EQELSFKKDDILYVDDTLPQGTFGSWMAWQLD 1640

  Fly  1639 AMGHRKECGIIPSQMKVEEE----LRSGEVVDCDTGTARRGSTSARRSFFRRK-KNQRSSSRDST 1698
            ....:.:.|.|||:..:::|    |...||.| |....:..|.:||||||||| |::||.|:|..
Human  1641 ENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKD-DNSATKTLSAAARRSFFRRKHKHKRSGSKDGK 1704

  Fly  1699 EIA---SFSNTQLSFFPDLGLLNDDGGALSYQRVELLDSPIRRPVLIIGPLSECLMVRLTIDFSN 1760
            ::.   :||:..:..|       :|..:|:||||:.:|....|||||:|||.:.:...|..:...
Human  1705 DLLALDAFSSDSIPLF-------EDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPG 1762

  Fly  1761 LFKLCEVTAMDCSQEAMEEGLKENIFVDYRRRGNKFECTTVEAISNACKNDRRHCILDVSISAVE 1825
            .|..|.:..|..||:|:|.|:|:.:||||:||...|:.|||.:|....:.: |||:||::..|:|
Human  1763 KFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKN-RHCLLDIAPHAIE 1826

  Fly  1826 RLQRLQIYPIVLLLRFKSAKQIRDIRD--FGTDKISAKAAKEMYERAMKLETDYKQYISAVIPGV 1888
            ||..:.|||||:.:.:||||.|::.||  :..||::.:.:||.:|.|.|||.:|.:|.:.||.|.
Human  1827 RLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEYSRYFTGVIQGG 1891

  Fly  1889 SIKHMCTQIKDAVDKEQDKLLWVP 1912
            ::..:||||...|::||:|:||:|
Human  1892 ALSSICTQILAMVNQEQNKVLWIP 1915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211	41/224 (18%)
		CENP-F_leu_zip	229..360	CDD:287450	40/184 (22%)
		DUF1090	<326..408	CDD:284007	33/81 (41%)
		PDZ_signaling	439..516	CDD:238492	21/99 (21%)
		PDZ_signaling	533..592	CDD:238492	19/58 (33%)
		PDZ_signaling	1290..1369	CDD:238492	35/78 (45%)
		PDZ_signaling	1497..1576	CDD:238492	26/79 (33%)
		SH3_DLG5	1594..1657	CDD:212794	28/62 (45%)
		Guanylate_kin	1737..1904	CDD:279019	69/168 (41%)
		NK	<1773..1905	CDD:302627	57/133 (43%)
DLG5	NP_004738.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..142
		Takusan	130..212	CDD:282652	8/24 (33%)
		TPR_MLP1_2	231..353	CDD:285204	29/137 (21%)
		COG1340	295..587	CDD:224259	80/316 (25%)
		FliJ	310..449	CDD:304890	25/141 (18%)
		BAR	417..601	CDD:299863	61/197 (31%)
		PDZ_signaling	620..707	CDD:238492	20/94 (21%)
		DegQ	<702..771	CDD:223343	21/70 (30%)
		PDZ_signaling	722..790	CDD:238492	22/71 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	927..1122		51/280 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1150..1187		11/40 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1201..1230		10/44 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1245..1264		3/25 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1271..1306		11/50 (22%)
		PDZ	1347..1429	CDD:214570	37/82 (45%)
		dbPDZ_assoc	1427..1499	CDD:293216	21/120 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1434..1493		17/107 (16%)
		PDZ	1499..1582	CDD:214570	29/93 (31%)
		SH3_DLG5	1597..1659	CDD:212794	28/62 (45%)
		GuKc	1732..1908	CDD:214504	70/176 (40%)
		Guanylate_kin	1740..1907	CDD:279019	69/167 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159060
Domainoid	1	1.000	124	1.000	Domainoid score	I5551
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	503	1.000	Inparanoid score	I1358
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47148
OrthoDB	1	1.010	-	-		D123652at2759
OrthoFinder	1	1.000	-	-		FOG0005387
OrthoInspector	1	1.000	-	-		oto88493
orthoMCL	1	0.900	-	-		OOG6_106741
Panther	1	1.100	-	-	LDO	PTHR46360
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5496
SonicParanoid	1	1.000	-	-		X4317
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800