DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and PDZD7

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_001182192.1	Gene:	PDZD7 / 79955	HGNCID:	26257	Length:	1033	Species:	Homo sapiens

Alignment Length:	1084	Identity:	213/1084 - (19%)
Similarity:	322/1084 - (29%)	Gaps:	482/1084 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   405 LLKEQMEQQERQNLDSNASGSRRSFRPSSYEGEDLL------------------EVELS------ 445
            ||::|      |.|   .:|..|..|.||..|..:|                  .||.|
Human    43 LLRKQ------QRL---LNGPPRGIRASSPMGRVILINSPIEANSDESDIIHSVRVEKSPAGRLG 98

  Fly   446 -----GYEHTSDLGIILDDSNKRKLVCGVTSSSPACGKLKINDVICKVNNLDCQSLSKRMVLDEI 505
                 |.||  .|||.:.     |:..|  ||:...| |.:.|.|.:||.|..:|.:....: ::
Human    99 FSVRGGSEH--GLGIFVS-----KVEEG--SSAERAG-LCVGDKITEVNGLSLESTTMGSAV-KV 152

  Fly   506 RACAPRSLLLVSR------TRHSKR----------------------------------HAYSVQ 530
            ...:.|..::|.|      .:.||.                                  |.|:
Human   153 LTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKCGSTPSDTSSEDGVRRIVHLYT-- 215

  Fly   531 LKTRDRDC-----PHGLQLDMGVFIAKIEQNSLAFYEPELDVGDRVLSINNKSMDSV---QSIEE 587
              |.|..|     ..|.:..:|::::|::...|| .|..:.|||:||:.|....|.:   |::|.
Human   216 --TSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLA-EENGIKVGDQVLAANGVRFDDISHSQAVEV 277

  Fly   588 -------VMQLMNDPRSDGLNLFALKY---------VQDQLPPGMTTSSAQTDSIDSMQHVSSAG 636
                   ::.:....|.........:|         |..||.|...:||:          |||.
Human   278 LKGQTHIMLTIKETGRYPAYKEMVSEYCWLDRLSNGVLQQLSPASESSSS----------VSSC- 331

  Fly   637 GGGGSGPSSATKHPSRFAEFFFRKLKFSKPGT---------------PEDNFEQE---------- 676
              ..|.|.|:...||...:..   |...:||:               |:.....|
Human   332 --ASSAPYSSGSLPSDRMDIC---LGQEEPGSRGPGWGRADTAMQTEPDAGGRVETWCSVRPTVI 391

  Fly   677 -HDDAIAA--------LDSVLSEN----------------SSEKSKENLFNRKKRTKKEK----- 711
             .|.||.:        |||.|||:                :..:|...|:..|::.||||
Human   392 LRDTAIRSDGPHPGRRLDSALSESPKTALLLALSRPRPPITRSQSYLTLWEEKQQRKKEKSGSPG 456

  Fly   712 -----EASKSM------------------------------GTWPRTNISHENPTGTM------- 734
                 :.||::                              .|:||.:|......|.:
Human   457 EKGALQRSKTLMNLFFKGGRQGRLARDGRREAWTLDSGSLAKTYPRLDIEKAGGVGPVQKFVTWR 521

  Fly   735 --RGNEKKRALMSLFTAGPI----NVDK---------------------DDELMG---------- 762
              |..|:.|||:|..:..|.    |||:                     |||::.
Human   522 LRRDQERGRALLSARSGSPSSQLPNVDEQVQAWESRRPLIQDLAQRLLTDDEVLAVTRHCSRYVH 586

  Fly   763 EVGV-------------PEKQPAALIQD--------------------QL------------PPP 782
            |.|:             |||  ..|:||                    :|            ||.
Human   587 EGGIEDLVRPLLAILDRPEK--LLLLQDIRSVVAPTDLGRFDSMVMLVELEAFEALKSRAVRPPA 649

  Fly   783 LPP--QMSKPLAH----IRGSNGGAIKTHPNRNSNPVSSGVSALFPPGPPNG-----------MP 830
            |.|  |.:.|..|    :..|.||....       ||:.     ||....||           .|
Human   650 LRPARQDTPPKRHLITPVPDSRGGFYLL-------PVNG-----FPEEEDNGELRERLGALKVSP 702

  Fly   831 NTSYPTHPRHSLYGVTAEEINQKPIQRAPL-------MGANARVKMPSQERYGTRPH--SNHRLS 886
            :.|.|.||...:          .|:|..|:       :......::|.......||:  ....||
Human   703 SASAPRHPHKGI----------PPLQDVPVDAFTPLRIACTPPPQLPPVAPRPLRPNWLLTEPLS 757

  Fly   887 LNITPSGDFYQPKTSGQQAQQQVMNASSTSAGFGVGSGSMVGGTGPAAGEFPVRKQQVYDVFHPP 951
            ....|     |.:..| :||.:..:.|.:.:....|.|...|...|:    ||          |.
Human   758 REHPP-----QSQIRG-RAQSRSRSRSRSRSRSSRGQGKSPGRRSPS----PV----------PT 802

  Fly   952 PLPKNSSGSNMFMPLHPTRGSHPPPVGQPPDVVSLK-------SQNSIESILSAKSPAISEYGMY 1009
            |.|..::|.     .|..|.:. ||:.:|.|..:.|       |::..|.  :||..|:..
Human   803 PAPSMTNGR-----YHKPRKAR-PPLPRPLDGEAAKVGAKQGPSESGTEG--TAKEAAMKN---- 855

  Fly  1010 AKRHVPQAVRHVPKYPSDSESIGSGVHGGYGGFLQSNHMPGNRHTQLFPTFGPGGRG-------- 1066
                 |.............:|:|..:.||    ::|...|..:..::|    |||..
Human   856 -----PSGELKTVTLSKMKQSLGISISGG----IESKVQPMVKIEKIF----PGGAAFLSGALQA 907

  Fly  1067 -----------------------------NRRSSPLTL------PSPPPQQQLQQLPAATAPHDS 1096
                                         |:...|:.|      |||.|           :|.||
Human   908 GFELVAVDGENLEQVTHQRAVDTIRRAYRNKAREPMELVVRVPGPSPRP-----------SPSDS 961

  Fly  1097 V-----GIPTDLDYHPHHHTQTNA------MPHPHPHPHAPYLD 1129
            .     |:|.  |:.|.|.....|      :|.|..:|..|..|
Human   962 SALTDGGLPA--DHLPAHQPLDAAPVPAHWLPEPPTNPQTPPTD 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007	2/2 (100%)
		PDZ_signaling	439..516	CDD:238492	23/105 (22%)
		PDZ_signaling	533..592	CDD:238492	18/73 (25%)
		PDZ_signaling	1290..1369	CDD:238492
		PDZ_signaling	1497..1576	CDD:238492
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
PDZD7	NP_001182192.1	PDZ_signaling	84..164	CDD:238492	22/90 (24%)
		PDZ_signaling	209..289	CDD:238492	20/84 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..380		14/72 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..464		5/19 (26%)
		HN_PDZD7_like	554..630	CDD:259824	11/77 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..864		31/146 (21%)
		PDZ_signaling	860..948	CDD:238492	13/95 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	943..1033		19/74 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810