DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dlg5 and CARD14

DIOPT Version :9

Sequence 1:NP_609505.1 Gene:Dlg5 / 34573 FlyBaseID:FBgn0032363 Length:1916 Species:Drosophila melanogaster
Sequence 2:NP_001353314.1 Gene:CARD14 / 79092 HGNCID:16446 Length:1004 Species:Homo sapiens


Alignment Length:729 Identity:158/729 - (21%)
Similarity:264/729 - (36%) Gaps:237/729 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  1319 TVADKSTAMRAGLQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLVQYNPEKFPSIEYEGA 1383
            ::.:|.:..|...::.||:.|:       .||      |||        :|..|   |.:..:.|
Human   378 SLVEKDSLRRQVFELTDQVCEL-------RTQ------LRQ--------LQAEP---PGVLKQEA 418

  Fly  1384 HNLEP----------------------------ESPINHSGSPTP---------RNSPRPPARNS 1411
            ...||                            ||.:....|.|.         .:||.||::.|
Human   419 RTREPCPREKQRLVRMHAICPRDDSDCSLVSSTESQLLSDLSATSSRELVDSFRSSSPAPPSQQS 483

  Fly  1412 LFP----------------LPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPS 1460
            |:.                |.:....|...||::|...|...             ::..:.|:|.
Human   484 LYKRVAEDFGEEPWSFSSCLEIPEGDPGALPGAKAGDPHLDY-------------ELLDTADLPQ 535

  Fly  1461 SAATTTTTT-----ASATSTVYDEEPKPSLPPPPASVPAETLRYVTLHMDKSKNL--GIKLFGGN 1518
            ..::....:     .|.:..:....|...:           |..||:...:...|  .|.:.|||
Human   536 LESSLQPVSPGRLDVSESGVLMRRRPARRI-----------LSQVTMLAFQGDALLEQISVIGGN 589

  Fly  1519 KVGIYVHDVAVGSPSDHAGIRKGDQI--LEYNGVD------LSGVTAEQAANEISKL-------- 1567
            ..||::|.|..||.:|...:|.|.||  ::|...:      |...|.|:|...:.::        
Human   590 LTGIFIHRVTPGSAADQMALRPGTQIVMVDYEASEPLFKAVLEDTTLEEAVGLLRRVDGFCCLSV 654

  Fly  1568 ---TDTVTMLVQN---KLHTLKQIKDEPGDSFYIRVGFDRTGELNEDDLRFVKDEVLYVDNTVFN 1626
               ||....|:|:   |:.|       .||||||||.....|.. :.:|:...:|||:|.:|:|.
Human   655 KVNTDGYKRLLQDLEAKVAT-------SGDSFYIRVNLAMEGRA-KGELQVHCNEVLHVTDTMFQ 711

  Fly  1627 GTFGLWRAWKL------DAMGHRKECGIIPSQMKVEEELRSGEVVDCDTGTARRGSTSARRSFFR 1685
            |. |.|.|.::      |...|    |.||:..:.:::|     :.......::.:.:.:.|...
Human   712 GC-GCWHAHRVNSYTMKDTAAH----GTIPNYSRAQQQL-----IALIQDMTQQCTVTRKPSSGG 766

  Fly  1686 RKKNQRSSSRDSTEIASFSNTQLSFFPDLGLLNDDGGALSYQRVE-----------------LLD 1733
            .:|..|..|.|.   |..|..:|||         |.|.|...|:|                 .|.
Human   767 PQKLVRIVSMDK---AKASPLRLSF---------DRGQLDPSRMEGSSTCFWAESCLTLVPYTLV 819

  Fly  1734 SPIR----RPVLIIGP------LSE--CLMVRLTIDFSNLFKLCEVTAMDCSQEAMEEGLKENIF 1786
            .|.|    ||||:: |      |||  ||:        ..||.|           :.|.|.:..:
Human   820 RPHRPARPRPVLLV-PRAVGKILSEKLCLL--------QGFKKC-----------LAEYLSQEEY 864

  Fly  1787 VDYRRRGNKFE--------CTTVEAISNACKNDRRHCILDVSISAVERLQRLQIYPIVL--LLRF 1841
            ..:.:||:..:        |........:......|.:|||.:.:|..|.|:.|:|||:  .:..
Human   865 EAWSQRGDIIQEGEVSGGRCWVTRHAVESLMEKNTHALLDVQLDSVCTLHRMDIFPIVIHVSVNE 929

  Fly  1842 KSAKQI-RDIRDFGTDKISAKAAKEMYERAMKLETDYKQ----YISAVIPGVS-IKHMCTQIKDA 1900
            |.||:: :.::..||.:      :::.|.|.:.|.|..:    |.|....|.| :..:.:.::.|
Human   930 KMAKKLKKGLQRLGTSE------EQLLEAARQEEGDLDRAPCLYSSLAPDGWSDLDGLLSCVRQA 988

  Fly  1901 VDKEQDKLLWVPVS 1914
            :..||.|::|...|
Human   989 IADEQKKVVWTEQS 1002

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dlg5NP_609505.1 AAA_23 <165..333 CDD:290211
CENP-F_leu_zip 229..360 CDD:287450
DUF1090 <326..408 CDD:284007
PDZ_signaling 439..516 CDD:238492
PDZ_signaling 533..592 CDD:238492
PDZ_signaling 1290..1369 CDD:238492 10/49 (20%)
PDZ_signaling 1497..1576 CDD:238492 27/99 (27%)
SH3_DLG5 1594..1657 CDD:212794 21/68 (31%)
Guanylate_kin 1737..1904 CDD:279019 44/194 (23%)
NK <1773..1905 CDD:302627 30/147 (20%)
CARD14NP_001353314.1 CARD_CARD14_CARMA2 19..104 CDD:260068
SMC_N <151..448 CDD:330553 16/93 (17%)
Maintains the protein in an inactive state. /evidence=ECO:0000269|PubMed:27071417 409..568 26/185 (14%)
PDZ_signaling 583..655 CDD:238492 20/71 (28%)
SH3 680..742 CDD:327375 21/67 (31%)
NK <858..961 CDD:327404 24/108 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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