DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlg5 and Whrn

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_001008791.1	Gene:	Whrn / 73750	MGIID:	2682003	Length:	918	Species:	Mus musculus

Alignment Length:	321	Identity:	79/321 - (24%)
Similarity:	127/321 - (39%)	Gaps:	88/321 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1287 PGDLRRVTI--DKRDKSLGITIQ-CNNNGGGIFVSTVADKSTAMRAGLQVGDQLLEVCGINMRAA 1348
            ||::|.|::  .|..:.||.:|: .:.:|.||:||.|...|.|.:.||:||||:|.|...::...
Mouse   136 PGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARV 200

  Fly  1349 TQEIAANVLRQCGDSFTMLVQYNPEKFPSIEYEGAHNLEPESPINHSGSPTPRNSPRPPARNSLF 1413
            |...|...|:  |....:|..|:..:.|     |.:                       ..|.::
Mouse   201 THAEAVKALK--GSKKLVLSVYSAGRIP-----GGY-----------------------VTNHIY 235

  Fly  1414 PLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYD 1478
            .. :.||..||.|.|..|..|.|...|       .:.|..|:..:..|.               |
Mouse   236 TW-VDPQGRSTSPPSSLPQPHGSTLRQ-------REDDRRSTLHLLQSG---------------D 277

  Fly  1479 EEPKPSLPPPPASVPAETLRYVTLHMDKSKNLGIKLFGGNK--VGIYVHDVAVGSPSDHAGIRKG 1541
            |                  :.|.|.:...::||:.:.||.:  :|||:..|..||.::.:|::.|
Mouse   278 E------------------KKVNLVLGDGRSLGLTIRGGAEYGLGIYITGVDPGSEAESSGLKVG 324

  Fly  1542 DQILEYNGVDLSGVTAEQAANEISKLTDTVTMLVQNKLHTLKQIKDEPGDSFYIRVGFDRT 1602
            |||||.||.....:           |.|....|:::..|.:..:|| .|...:.|...|:|
Mouse   325 DQILEVNGRSFLNI-----------LHDEAVKLLKSSRHLILTVKD-VGRLPHARTTVDQT 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	27/81 (33%)
		PDZ_signaling	1497..1576	CDD:238492	24/80 (30%)
		SH3_DLG5	1594..1657	CDD:212794	3/9 (33%)
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
Whrn	NP_001008791.1	HN_L-whirlin_R1_like	38..113	CDD:259822
		PDZ_signaling	139..216	CDD:238492	26/78 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..266		10/32 (31%)
		PDZ_signaling	278..358	CDD:238492	26/108 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..407
		HN_L-whirlin_R2_like	420..500	CDD:259823
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..824
		PDZ_signaling	827..898	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810