DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and dlg1

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	XP_031757617.1	Gene:	dlg1 / 733937	XenbaseID:	XB-GENE-1016132	Length:	939	Species:	Xenopus tropicalis

Alignment Length:	960	Identity:	211/960 - (21%)
Similarity:	369/960 - (38%)	Gaps:	301/960 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1071 SPLTLPS-----PPPQQQLQQLPAATAPHDSVGIPTDLDYHPHHHTQTNAMPHPHPHPHAPYLDY 1130
            |||..|.     ||....:..:|          :|          .::|.:|...|..:.|.:..
Frog   158 SPLKTPEADTPCPPIVPVIPVIP----------VP----------AESNVIPSSTPQANPPPVIV 202

  Fly  1131 GHGLGIGPYMGVGG--------------GVSGVGGAIYEGGTFPRKKDNQRL---------RIPS 1172
            ...|....|  |.|              |.||:|.:| .|||     ||..:         :|.|
Frog   203 NTDLETPAY--VNGTDAEYEYEEITLERGTSGLGFSI-AGGT-----DNPHIGDDISIFITKIIS 259

  Fly  1173 NPSVASKSSSMVKN---SSGSIDHHYVTSTGPV-----SGGSMSASSSDRAPMS--LMSSSIHNS 1227
            ..:.|......|.:   ....:|.|.||.:..|     :|..:......|.|::  :|...:
Frog   260 GGAAAQDGRLRVNDCILRVNEVDVHDVTHSKAVEALKEAGSIVRLYVRRRKPVTEKIMDIKL--- 321

  Fly  1228 YGANIAGGNGTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRR 1292
                :.|..|.|.||                           .||.|  |.::|.|
Frog   322 ----VKGPKGLGFSI---------------------------AGGVG--NQHIPGD--------- 344

  Fly  1293 VTIDKRDKSLGITIQCNNNGGGIFVSTVADKSTAMRAG-LQVGDQLLEVCGINMRAATQEIAANV 1356
                                ..|:|:.:.:...|.:.| ||:||:||.|..:.:...:.|.|...
Frog   345 --------------------NSIYVTKIIEGGAAHKDGRLQIGDKLLAVNTVCLEEVSHEDAVTA 389

  Fly  1357 LRQCGD--------SFTMLVQYN---PEKFPSIEYEGAHNLEPESPINHSGSPTPRNSPRPPARN 1410
            |:...|        ..||.:..|   |:...|...:..:::.|...|.|         |.||:
Frog   390 LKNTSDFVNLKVAKPTTMYMNDNYAPPDITNSYSQQVDNHISPSGFIGH---------PLPPS-- 443

  Fly  1411 SLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATST 1475
                           ||..:|.....::|...|
Frog   444 ---------------PGRYSPAPKGMLEDDDLT-------------------------------- 461

  Fly  1476 VYDEEPKPSLPPPPASVPAETLRYVTLHMDKSKNLGIKLFGG-NKVGIYVHDVAVGSPSDHAG-I 1538
               .||                |.|.|... :..||..:.|| :..||::..:..|.|:|.:| :
Frog   462 ---REP----------------RKVVLQRG-TTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL 506

  Fly  1539 RKGDQILEYNGVDLSGVTAEQAANEISKLTDTVTMLVQ----------NKLHTLKQ--------- 1584
            :|||:|:..|||||...|.||||..:.....|||::.|          .|:|.|::
Frog   507 QKGDRIMSVNGVDLKSATHEQAAAALKNAGQTVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISS 571

  Fly  1585 ----IKDEPGDSFYIRVGFD----RTGELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMG 1641
                ::.....|.|:|..||    :...|....|.|...::|:|.|.   .....|:|.::.|.|
Frog   572 GSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVVNA---SDDEWWQARQVTADG 633

  Fly  1642 HRKECGIIPSQMKVEEELRSGEVVDCDTGTARRG------STSARRSFFRRK----KNQRSSSRD 1696
            ..:|.|:|||:.:||::.|: .:......:..||      :...:::.|.||    ||:..|..:
Frog   634 ESEEIGVIPSKRRVEKKERA-RLKTVKFNSKARGDKGQSFNDKRKKNLFSRKFPFYKNKDQSEME 697

  Fly  1697 STEI-----ASFSNTQLSFFPDLGLLNDDGG---------ALSYQRVELLDSPIRRPVLIIGPLS 1747
            ::::     ::.|:::.|:   |.|:.|:.|         .|||:.|...:....|||:|:||..
Frog   698 TSDVDQHVTSNASDSESSY---LILITDEYGCSQGGQEEYVLSYEPVNQQEVNYSRPVIILGPTK 759

  Fly  1748 ECLMVRLTIDFSNLFKLC-----------EVTAMD----CSQEAMEEGLKENIFVDYRRRGNKFE 1797
            :.:...|..:|...|..|           |:...|    .|:|.||:.::::.|::..:..:...
Frog   760 DRVNDDLISEFPEKFGSCVPHTTRPKRDYEIDGRDYHFVTSREQMEKDIQDHRFIEAGQYNSHLY 824

  Fly  1798 CTTVEAISNACKNDRRHCILDVSISAVERLQRLQIYPIVLLLRFKSAKQIRDIRDFGTDKISAKA 1862
            .|:|:::....:.. :|||||||.:|::|||..|:|||.:.::.||.:.|.::    :.:::.:.
Frog   825 GTSVQSVKEVAERG-KHCILDVSGNAIKRLQIAQLYPIAIFIKPKSVENIIEM----SKRVTEEQ 884

  Fly  1863 AKEMYERAMKLETDYKQYISAVIPGVSIKHMCTQIKDAVDKEQDKLLWVP 1912
            .::.||||||||.::.::.:|::.|.:::.:..|||..::::....:|||
Frog   885 GRKTYERAMKLEQEFTEHFTAIVQGDTLEEIYNQIKQIIEEQSSTFIWVP 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	17/87 (20%)
		PDZ_signaling	1497..1576	CDD:238492	30/80 (38%)
		SH3_DLG5	1594..1657	CDD:212794	20/66 (30%)
		Guanylate_kin	1737..1904	CDD:279019	50/181 (28%)
		NK	<1773..1905	CDD:302627	38/131 (29%)
dlg1	XP_031757617.1	L27_1	2..62	CDD:401120
		MAGUK_N_PEST	106..222	CDD:402306	16/85 (19%)
		PDZ_signaling	223..307	CDD:238492	20/89 (22%)
		PDZ_signaling	316..402	CDD:238492	27/150 (18%)
		PDZ_assoc	403..465	CDD:402299	18/138 (13%)
		PDZ	463..547	CDD:214570	33/100 (33%)
		SH3_DLG1	582..648	CDD:212964	20/68 (29%)
		Guanylate_kin	748..926	CDD:395500	50/182 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910