DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and Dlg5

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	XP_017171686.1	Gene:	Dlg5 / 71228	MGIID:	1918478	Length:	1931	Species:	Mus musculus

Alignment Length:	2143	Identity:	554/2143 - (25%)
Similarity:	889/2143 - (41%)	Gaps:	562/2143 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LSLTSTSSQEEESSEYVGYDNTLRPPS------NSSGSTTAANMS--------NNNGPSKGVSSG 59
            ||:..:.|:...|...||  .|.:.||      ....:.|..|:|        ..|...|.::..
Mouse   108 LSIMPSDSESSSSLSSVG--TTGKAPSPPPLLTEQQANDTVENLSIQLRLMTRERNELRKRLAFA 170

  Fly    60 VGVSGISGGNGA------------NYDILQAQYKSALLELNTLRHQHANTKRRCDELATELTLY- 111
            .        :||            :|:.|:.|...|:.:|.:|::||.|..:||:|:|.|...|
Mouse   171 T--------HGATFDKRPYHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYH 227

  Fly   112 --QEHYVADRNKFTDMVEESAR------------------FKRLLLETQNQ----QSQQAQ---- 148
              ....::|:.:..|.|:...|                  .|||..|.|.:    ::||.|
Mouse   228 TLHSRLLSDQTQLKDDVDMLRRENGKLRRERNLLQQSWEDMKRLREEDQKEIGDLRAQQQQVLKH 292

  Fly   149 NGNSQVPPVGSGNPYYFGKTQGCDGSCSEKLAELKKERNMVAVEREKYKKSYIELEKDRNYYRER 213
            ||:|::.     |..|        .:..:||..:||:.:.:   |::|.:.......|.:...:.
Mouse   293 NGSSEIL-----NKLY--------DTAMDKLEVVKKDYDAL---RKRYSEKVAMHNSDLSRLEQL 341

  Fly   214 GDENQKLK---VLLSQESKNVLSLT--------------EELNQLLSEKDNVLQEHQKMSDDL-- 259
            |:|||:|:   .:|:|:....:.|.              .||::..::..::..|.:.:..:|
Mouse   342 GEENQRLQKQTEMLTQQRDTAIQLQHQCALSLRRFETIHHELSKATAQNKDLQWEMELLQSELTE 406

  Fly   260 -----VLANKEIERLKKDEQLARAEIKVL------------------QLANADLKKRDLLKSRDS 301
                 |...||.|:.|::.....:|.|::                  :||.:.||         |
Mouse   407 LRSKQVKTAKESEKYKEERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLK---------S 462

  Fly   302 SWSKEFPSGKELE---------------NSKELEKLRKSLEKALSEVERSSQDAEEAKRVRDWAI 351
            |.|::..:.:|:|               .:||:|.|||..:....|::.:.|:|:.||..||||.
Mouse   463 STSEKKAASEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAF 527

  Fly   352 SQREKIVQERDSVKTLCDKMRHERDKAISDSLMAIRDSEKIKKQKDEAQKKIDLL-----KEQME 411
            .:|:|||.||||::||||.:|.|||:|:|:...|:|..:..:|||::..:::..|     :||||
Mouse   528 QERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELNSCVHREQME 592

  Fly   412 QQERQNLDSNASGSRRSFRPSSYEG---EDLLEVELSGYE---HTSD-----LGIILDDSNKRKL 465
            .|    |:..|. .|:....||::.   .|.:|.|....|   .|.|     ||..:.:......
Mouse   593 CQ----LEKEAR-FRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPC 652

  Fly   466 V---CG-----VTSSSPACGKLKINDVICKVNNLDCQSLSKRMVLDEIRACAPRSLL-------L 515
            .   ||     |...|.|.|:|::||.:.::|::|..:..|:..:        ::||       :
Mouse   653 FPGDCGIFVTKVDKGSIADGRLRVNDWLLRINDVDLINKDKKQAI--------KALLNGEGAINM 709

  Fly   516 VSRTRHS-------KRHA-YSVQLKTRDRDCPHGLQLDMGVFIAKIEQNSLAFYEPELDVGDRVL 572
            |.|.|.|       ..|. .|.|..:|.:|  .|:.|:.||:.|.:...|.|..|..|.||||::
Mouse   710 VVRRRKSLGGKVVTPLHINLSGQKGSRPQD--SGISLENGVYAAAVVPGSPAAKEGSLAVGDRIV 772

  Fly   573 SINNKSMDSVQSIEEVMQLMNDPRSDGLNLFALK-YVQDQLPPGMT------------------- 617
            :||..::|: :|:.|...|:...: |.|.|..|| :.|.....|..
Mouse   773 AINGIALDN-KSLNECESLLRSCQ-DSLTLSLLKVFPQSSSWSGQNIFENIKDSDRMLSCRAHGP 835

  Fly   618 -------------TSSAQTDSI--DSMQHVSSAGGGGGSG-----PSSATKHPSRFAEFFFRKLK 662
                         .:|.|||..  |.::.....|..|||.     |.|.:..|..         .
Mouse   836 EVQAHNKRNLLQHNNSTQTDIFYTDRLEDRKELGHSGGSSSFLHKPFSGSSSPVS---------P 891

  Fly   663 FSKPGTPEDNFEQEHDDAIAALDSVLSENSSEKSKENLFNRKKR-------------------TK 708
            .:.|.|.|           .:|:|..|:.|:|:....:..|.:|                   .|
Mouse   892 QACPSTSE-----------RSLNSFRSDTSAERGYGLVDMRSQRPLLSFETEVGPCGAVEVPLDK 945

  Fly   709 KEKEASKSMGTWPRTNISHENPTGTMRGNEKKRALMSLFTAGPINVDKDDELMGEVGVPE--KQP 771
            .:.|.|.|.||||:..:      |:..|.||            ::|.|..:....:..|.  |:|
Mouse   946 IDPEGSNSGGTWPKAVL------GSTSGPEK------------LSVYKKPKQRKSIFDPNTFKRP 992

  Fly   772 AALIQDQLPPPLPPQMSKP-LAHIRGSNGGAIKTHPNRNSNPVSSGVSALFPPGPPNGMPNTSYP 835
                  |.||.:...:..| |.|                |...|..|.:|.||.||....:..:
Mouse   993 ------QTPPKIDYLLPGPGLTH----------------SPQPSKRVGSLTPPKPPRRSDSIKF- 1034

  Fly   836 THPRHSLYGVTAEEINQKPIQRAPLMGANARVKMPSQERYGTRPHSNHRLSLNITPSGDFYQPKT 900
               :|.|  .|:.|      ..|.|:|::.....||..                .||.|..:|..
Mouse  1035 ---QHRL--ETSSE------SEATLVGSSPSTSPPSAP----------------PPSMDPSEPTH 1072

  Fly   901 SGQQAQQQVMNASSTSAGFGVGSGSMVGGTGPAAGEFPVRKQQVYDVFHPPPLPKNSSGSNMFMP 965
            :....:.:|..|||..:. |.|..|.:....|.  :..:..|:|.::......||::
Mouse  1073 ASPPRKARVRIASSYHSE-GDGDTSYLPAKKPC--DEDLTSQKVDELGQKRRRPKSA-------- 1126

  Fly   966 LHPTRGSHPPPVGQPPDVVSLKSQNSIESILSAKSPAISEYGMYAKRHVPQAVRH-----VPKYP 1025
              |:......||..|..  .|:.|..:.:| ...||...|:..|:..|   |.||     .|..|
Mouse  1127 --PSFRPKISPVVIPAQ--CLEEQECVPAI-GELSPEGQEWSPYSPGH---ASRHGNPLLYPNRP 1183

  Fly  1026 SDSESIGSGVHGGYGGFLQSNHMPGNRHTQLFPTFGPGGRGNRRSSPLTLPSPPPQQQLQQLPAA 1090
            |......|...|...|.:..|.:...|..::.|...|               |.|:....|..:.
Mouse  1184 SVGTVPRSMTPGTTVGSILRNPIYTVRSHRVLPCGSP---------------PVPRDAGSQSLSP 1233

  Fly  1091 TAPHDSVGIPTDLDYHPHHHTQTNAMPHPHPHPHAPYLDYGHGLGIGPYMGVGGGVSGVGGAIYE 1155
            :..|.. .:..||.                   |....||..       |....|.:.:..:...
Mouse  1234 SVQHQG-RLSLDLS-------------------HRACSDYSE-------MRASQGSNSLPSSARL 1271

  Fly  1156 GGTFPRKKDNQRLRIPSNPSVASKSSSMVKNSSGSIDHHYVTSTGPVSGGSMSASSSDRAPMSLM 1220
            |.:...:...:|::||..|..   ..|::.:..||:.|. ..||.|.|..::...||...|.:..
Mouse  1272 GSSSNLQFKAERIKIPLTPRY---PRSVMGSDRGSLSHS-ECSTPPRSPLNIDTLSSCSQPQTTA 1332

  Fly  1221 SSSIHNSYGANIAGGNGTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFL 1285
            |:                                   :|::.|...||     |:|..:.|  |:
Mouse  1333 ST-----------------------------------LPRIAVNPSSH-----GERRKDRP--FV 1355

  Fly  1286 CPGDLRRVTIDKRDKSLGITIQCNNNGGGIFVSTVADKSTAMRAGLQVGDQLLEVCGINMRAATQ 1350
              .:.|.|.:.|..:.|||:| .:...||::||.|...|.|.:|||:.||||||..|||:|:||:
Mouse  1356 --EEPRHVKVQKGSEPLGISI-VSGEKGGVYVSKVTLGSIAHQAGLEYGDQLLEFNGINLRSATE 1417

  Fly  1351 EIAANVLRQCGDSFTMLVQYNPEKFPSIEYEGAHN---------LEPESPINHSGSPTPRNSPRP 1406
            :.|..::.|..|:.|:|.||||.    |....:|:         ..|.|.:..|.:.||.:.
Mouse  1418 QQARLIIGQQCDTITILAQYNPH----IHQLNSHSRSSSHLDPAATPHSTLQGSSAGTPEHP--- 1475

  Fly  1407 PARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTAS 1471
               :.:.||..|.:.|.|.|..::..|.:|:.|                         ||..|
Mouse  1476 ---SVIDPLMEQDEGPGTPPAKQSASSTRSVGD-------------------------TTKKT-- 1510

  Fly  1472 ATSTVYDEEPKPSLPPPPASVPAETLRYVTLHMDKSK-NLGIKLFGGNKVGIYVHDVAVGSPSDH 1535
                     |.|.:                :.:.||: :||:.|.|||..|::|.:|...||:..
Mouse  1511 ---------PDPRI----------------VFIKKSQLDLGVHLCGGNLHGVFVAEVEDDSPAKG 1550

  Fly  1536 A-GIRKGDQILEYNGVDLSGVTAEQAANEISKLTDTVTMLVQNKLHTLKQIKDEPGDSFYIRVGF 1599
            . |:..||.||||..:|:...|.|....|:.|..|::.:.||.:.....::|..||||||||..:
Mouse  1551 PDGLVPGDLILEYGSLDMRSRTVEDVYVEMLKPKDSLRLKVQYRHEEFTRVKGLPGDSFYIRALY 1615

  Fly  1600 DRTGELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRKECGIIPSQMKVEEE----LR 1660
            ||..|: |.:|.|.||::||||:|:..|.||.|.||:||....:.:.|.|||:..:::|    |.
Mouse  1616 DRLAEV-EPELSFKKDDILYVDDTLPQGVFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLS 1679

  Fly  1661 SGEVVDCDTGTARRGSTSARRSFFRRK-KNQRSSSRDSTEIA---SFSNTQLSFFPDLGLLNDDG 1721
            ..||.  |..||:..|.:||||||||| |::||.|:|..::.   :|||..:..|       :|.
Mouse  1680 MSEVK--DDNTAKTLSAAARRSFFRRKHKHKRSGSKDGKDLLALDTFSNDSIPLF-------EDS 1735

  Fly  1722 GALSYQRVELLDSPIRRPVLIIGPLSECLMVRLTIDFSNLFKLCEVTAMDCSQEAMEEGLKENIF 1786
            .:|:||||:.:|....||||::|||.:.:...|..:....|..|.:..|..||:|:|.|:|:.:|
Mouse  1736 VSLAYQRVQKVDCTSLRPVLLLGPLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLF 1800

  Fly  1787 VDYRRRGNKFECTTVEAISNACKNDRRHCILDVSISAVERLQRLQIYPIVLLLRFKSAKQIRDIR 1851
            |||:||...|:.|||.:|....:.: |||:||::..|:|||..:.|||||:.:|:||||.|::.|
Mouse  1801 VDYKRRSGHFDVTTVASIKEITEKN-RHCLLDIAPHAIERLHHMHIYPIVIFIRYKSAKHIKEQR 1864

  Fly  1852 D--FGTDKISAKAAKEMYERAMKLETDYKQYISAVIPGVSIKHMCTQIKDAVDKEQDKLLWVP 1912
            |  :..||::.:.:||.:|.|.|::.:|.:|.:.|:.|.::..:||||...|.:||.|:||:|
Mouse  1865 DPVYLRDKVTQRHSKEQFETAQKIDQEYSRYFTGVVQGGALSSICTQILAMVSQEQSKVLWIP 1927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211	41/224 (18%)
		CENP-F_leu_zip	229..360	CDD:287450	40/184 (22%)
		DUF1090	<326..408	CDD:284007	33/86 (38%)
		PDZ_signaling	439..516	CDD:238492	21/99 (21%)
		PDZ_signaling	533..592	CDD:238492	20/58 (34%)
		PDZ_signaling	1290..1369	CDD:238492	34/78 (44%)
		PDZ_signaling	1497..1576	CDD:238492	26/80 (33%)
		SH3_DLG5	1594..1657	CDD:212794	28/62 (45%)
		Guanylate_kin	1737..1904	CDD:279019	66/168 (39%)
		NK	<1773..1905	CDD:302627	55/133 (41%)
Dlg5	XP_017171686.1	Takusan	129..213	CDD:368141	25/112 (22%)
		Smc	<141..564	CDD:224117	131/544 (24%)
		PDZ_signaling	625..712	CDD:238492	29/88 (33%)
		PDZ_signaling	<741..800	CDD:238492	11/63 (17%)
		PDZ	1357..1439	CDD:214570	30/81 (37%)
		dbPDZ_assoc	1437..1512	CDD:374667	24/83 (29%)
		PDZ	1513..1594	CDD:214570	14/80 (18%)
		SH3_DLG5	1610..1672	CDD:212794	23/62 (37%)
		GuKc	1744..1920	CDD:214504	70/183 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849437
Domainoid	1	1.000	125	1.000	Domainoid score	I5462
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	507	1.000	Inparanoid score	I1324
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47148
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005387
OrthoInspector	1	1.000	-	-		oto92063
orthoMCL	1	0.900	-	-		OOG6_106741
Panther	1	1.100	-	-	LDO	PTHR46360
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5496
SonicParanoid	1	1.000	-	-		X4317
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790