DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and Slc9a3r2

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_075542.2	Gene:	Slc9a3r2 / 65962	MGIID:	1890662	Length:	337	Species:	Mus musculus

Alignment Length:	393	Identity:	80/393 - (20%)
Similarity:	125/393 - (31%)	Gaps:	119/393 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1299 DKSLGITIQCNNNGGGIFVSTVADKSTAMRAGLQVGDQLLEVCGINMRAAT-QEIAANVLRQCGD 1362
            ::..|..:.......|.|:..|...|.|..|.|:.||:|:||.|:|:...| .::...:....|.
Mouse    18 EQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQ 82

  Fly  1363 SFTMLVQYNPEKFPSIEYEGAHNLEPESPINHSGSPTPRNSPRPPARNSLFPLPMQPQAPSTRPG 1427
            :..::|....:     |......|.....:.|.|        .|||.|     |.:|:......|
Mouse    83 TQLLVVDKETD-----EELCRRQLTCTEEMAHRG--------LPPAHN-----PWEPKPDWACSG 129

  Fly  1428 SRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSLPPPPASV 1492
            |              ..|...|.|::.                          |...|.|....:
Mouse   130 S--------------LGSDTGQKDVNG--------------------------PPRELRPRLCHL 154

  Fly  1493 PAETLRY-VTLHMDKSKNLGIKLFGGNKVGIYVHDVAVGSPSDHAGIRKGDQILEYNGVDLSGVT 1556
            ......| ..||.|||           :.|.|:..|..|||:.|:|:|..|:::|.||.::.|:.
Mouse   155 RRGPQGYGFNLHSDKS-----------RPGQYIRSVDPGSPASHSGLRAQDRLIEVNGQNVEGLR 208

  Fly  1557 AEQAANEISKLTDTVTMLVQNKLHTLKQIKDEPGDSFYIRVGFDRTGELNEDDLRFVKDEVLYVD 1621
            ..:....|....|...:||          .|...|..:.|:....|.|..|..|          .
Mouse   209 HAEVVARIKAQEDEARLLV----------VDPETDEHFKRLRVIPTEEHVEGPL----------P 253

  Fly  1622 NTVFNGTFGL-----------------------WRAWKLDAMGHRKECG--IIPSQMKVEEELRS 1661
            :.|.|||...                       ...||.|..   :|.|  :.|:..:.:|:.|:
Mouse   254 SPVTNGTSPAQLNGGSVCSSRSDLPGSEKDNEDGSTWKRDPF---QESGLHLSPTAAEAKEKARA 315

  Fly  1662 GEV 1664
            ..|
Mouse   316 TRV 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	17/70 (24%)
		PDZ_signaling	1497..1576	CDD:238492	23/79 (29%)
		SH3_DLG5	1594..1657	CDD:212794	15/87 (17%)
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
Slc9a3r2	NP_075542.2	PDZ_signaling	9..88	CDD:238492	17/69 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..147		12/79 (15%)
		PDZ	148..230	CDD:214570	25/102 (25%)
		EBP50_C	232..337	CDD:286142	19/100 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..337		17/90 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900