DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dlg5 and Pdzd2

DIOPT Version :9

Sequence 1:NP_609505.1 Gene:Dlg5 / 34573 FlyBaseID:FBgn0032363 Length:1916 Species:Drosophila melanogaster
Sequence 2:XP_038959013.1 Gene:Pdzd2 / 65034 RGDID:619958 Length:2818 Species:Rattus norvegicus


Alignment Length:1896 Identity:373/1896 - (19%)
Similarity:604/1896 - (31%) Gaps:612/1896 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   135 LLLETQNQQSQQAQNGNSQVPPVGSGNPYYFGKTQGCD-GSCSEKLAELKKERNMVAVEREKYKK 198
            ::|....|::....|||       |||....|:|...: |..:.|..  |:.|....:.|....|
  Rat   174 IMLRRFKQKAHVTYNGN-------SGNSSEPGETPTLELGDQTSKKG--KRTRKFGVISRPSISK 229

  Fly   199 SYIELEKDRNYYRERGDENQKLKVLLSQESKNVLSLTEELNQLLSEKDNVLQEHQKMSDDLVLAN 263
            : .|..|..:......|.|.:|:.....|..|..:...| |...|.|| |...|.:.|:    |:
  Rat   230 T-PEDSKSSSGCDTADDPNSELENGADPELGNGHAFELE-NGPHSLKD-VAGPHLERSE----AD 287

  Fly   264 KEIE-RLKKDEQLARAEIKVLQLANADLKKRDLLKSRDSSWSKEFPSGKELENSKELEKLRKS-- 325
            .|:| |:.|.|         ..|::::.|:|.....:....|.:..:.:|:....::|.|::|  
  Rat   288 SEVELRVPKTE---------APLSDSNDKRRFSKTGKTDFQSSDCLAREEVGRIWKMELLKESDG 343

  Fly   326 --LEKALSEVERSSQDAEEAKRVRDWAISQREKIVQERDSVKT----LCDKMRHERDKAISDS-- 382
              ::.:.....:.|..|....:|::...:.|:..:...|.:..    |...:.||...||..|  
  Rat   344 LGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSAT 408

  Fly   383 -----LMAIRDS--EKIKKQKDEAQKKIDLLKEQM------EQQERQNLDSNASG--SRRSFRPS 432
                 ::|.::|  |.:.|...::...:....|.|      |.||....|...||  :.|...|.
  Rat   409 GMVQLVVASKESSAEDLLKLTSKSLPDLTSSVEDMSSWTDNEDQEAAGEDEEGSGPAAVRVTMPG 473

  Fly   433 SYEGEDL---------------------LEVELSG-------YEHTSDLGIILDDSNKRKLVC-- 467
            |.|.:|:                     |:..|||       .|..::|.:...|...|.|..  
  Rat   474 SEESQDVGSSEESKGNLESPKQGNCKTKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSR 538

  Fly   468 -GVTSSSP----ACGKLKINDVICKVNNLDCQSLSKRMVLDEIRACAPRSLLLVSRTRH-SKRHA 526
             |...|.|    :.|..:...::.|    ..:|||...|....|...|..:.::...:. .|...
  Rat   539 DGRKHSLPQLLDSTGTSQEYHIVKK----STRSLSTTHVESPWRLIRPSVISIIGLYKEKGKGLG 599

  Fly   527 YSVQLKTRDRDCPHGLQLDMGVFIAKIEQNSLAFYEPELDVGDRVLSINNKSMDSVQSIEEVMQL 591
            :|:   ...|||..|   .||:|:..|..|..|..:..|..||.:|.:|...:..: :.:|.:..
  Rat   600 FSI---AGGRDCIRG---QMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGL-TFQEAIHT 657

  Fly   592 MNDPRSDGLNLFALKYVQDQLPPGMTTSSAQT-------DSIDSMQHVSSAGGGGGSGPSSA--T 647
            ....||   .||.|......|.|.:|..|..|       .|.::....:.||||...|.||:  .
  Rat   658 FKQIRS---GLFVLTVRTKLLSPSLTPCSTPTHMSRSSSPSFNTNSGGTPAGGGQEEGGSSSLGR 719

  Fly   648 KHPSR----FAEFFFRK--------------LKFSKPG------TP-----------------ED 671
            |.|..    ..|....|              |:.|.||      .|                 |.
  Rat   720 KAPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEV 784

  Fly   672 NFEQEHDDAIAALDSVLSE----------------NSSEKSKENLFNRKK-RTKKEKEASKSMGT 719
            |.......|::.:.::||:                ..||:..:.:..|.. :..:|..:|..:||
  Rat   785 NSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESREANSSPGLGT 849

  Fly   720 WP--------RTNISHENPTGTMRGNEKKRALMSLFTAGPINVD---------KDDELM------ 761
             |        :.::..|:.......::.:.:|.....||..:.|         :|..|:      
  Rat   850 -PLKSPSLAKKDSLLSESELSQYFVHDGQGSLSDFVVAGSEDEDHPGSGYETSEDGSLLPVPSAH 913

  Fly   762 -----GEVGVPEKQPAALIQDQLP-------PPLPPQMSKPLAHIR-----GSNGGAIKTHPNRN 809
                 ..|.:..::.:.|:..|:.       |..|..:..||...|     .||||:.....:..
  Rat   914 KARANSLVTLGSQRTSGLLHKQVTVARQASLPGSPQVLRNPLLRQRRVRCYDSNGGSDDEDFDGE 978

  Fly   810 SNPVS-SGVSALFPPGPPNGMPNTSYPTHP-----RHSLYGVTAEEINQKP-IQRA---PLMGAN 864
            .:.:| .||.    |||  |.|.....|.|     ..|:.....||..||| :.:|   ||:|::
  Rat   979 GDCISLPGVL----PGP--GKPLVEDDTRPALTTSSKSIDVNKQEERLQKPLVSKACSVPLLGSS 1037

  Fly   865 -------------ARVKMPSQERYGTRPHSNHRLSLNITPSGDFYQPK----------------- 899
                         ...|:.|....|..|.:..|.|.....||....||                 
  Rat  1038 LDSEHSILNGTGGTPPKVASLPGSGETPKNGPRGSGRKEMSGSRSSPKLEYRVPTDTQSPRSPEN 1102

  Fly   900 -TSGQQAQQQVMNASSTSAGFG-----VGSGSMVGGT--GPAAGEFPVRKQQVYDVF-------- 948
             ||..|..:.:::.....|...     ..:....|||  ||.|.:..|:...|.|..        
  Rat  1103 HTSPPQKSENLVSRHKPVARISPHYKRSDAEEAPGGTANGPCAQDLKVQASPVKDPVTGRQPGGT 1167

  Fly   949 -------HPPP----LPKNSSGSNMFMPLHPTRG-SHPPPVGQPPDVVSLKS---QNSIESIL-- 996
                   :|.|    :|.|...::  .|.||..| ....|.|..|:.|....   ..|.|.:.  
  Rat  1168 AEKELQGNPTPGDSSVPTNCGPAS--TPCHPNTGLPTENPQGAAPECVPHPGTGWDGSSEHLCSP 1230

  Fly   997 ---------SAKSPAISEYGMYAKRHVPQAVRHVPKYPSDSESIGSGVHGGYGGFLQSNHMPGNR 1052
                     |:::|.::|     :.|.|:::.. |..|..||....|:         |...|.::
  Rat  1231 GKSREVHPDSSETPTVAE-----QVHQPESLSQ-PVSPRTSEPESQGI---------SKMKPPSQ 1280

  Fly  1053 HTQLFPTFGPGGRGNRRSSPLTLPSPPPQQQLQQLPAATAPHDS------VGIPTDLDYHPHHHT 1111
                           |..||....|.||...    .|..||.||      :.:|          .
  Rat  1281 ---------------RCVSPREKASTPPDSS----RAWAAPGDSSPSTRRIAVP----------M 1316

  Fly  1112 QTNAMPHPHPHPHAPYLDYGHGLGI-GPYMGVGGGVSGVGGAIYEGGTFPRKKDNQRLRIPSNPS 1175
            .|.|.| ....|.|..:......|: ||..|:|                     .:.|.||.   
  Rat  1317 STGAAP-ATAIPQASLVSQERSRGLSGPSKGLG---------------------TKELCIPK--- 1356

  Fly  1176 VASKSSSMVKN---SSGSIDHHYVTSTGPVSGGSMSASSSDRAPMSLMSSSIHNSYGANI----- 1232
             :.|..:::::   :||.:. |..:.:|||: ...:.|.|...|::.:.:.|..:..|.:     
  Rat  1357 -SLKDGALLEDTAPASGKMS-HASSPSGPVA-TERTLSGSPENPVTDIDNFIEEASEARLSQSPQ 1418

  Fly  1233 -----AGGNGTGSSIGVGGGGGGGS------------------GRGSPMPQ---VHVEVLSHGGG 1271
                 |.|: |..|...||.|...|                  |.|||.||   :...||     
  Rat  1419 KADCRAHGD-TFESQPPGGAGSSSSHHAQMVRSDQTSSPRKTGGTGSPPPQQWALQPSVL----- 1477

  Fly  1272 GSGKRNSNVPADFLCPGDLRRVTIDKRDKSLGITIQCNNNGGGIFVSTVADKSTAMRAGLQVGDQ 1336
                       |.:.|           ||.|.:.....||....|.:...|..:....|      
  Rat  1478 -----------DSIHP-----------DKHLAVNKTFLNNYSRNFSNFHEDSISLSGPG------ 1514

  Fly  1337 LLEVCGINMRAATQEIAANVLRQCGDSFTMLVQYNPEKFPSIEYEGAH--NLEPESPINHSGSPT 1399
                                    |.|         |..||..|..|.  :.:|||.....|:  
  Rat  1515 ------------------------GSS---------EPSPSSMYGNAEDSSSDPESLAEDPGA-- 1544

  Fly  1400 PRNSPRPPARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAAT 1464
                   .|||:..|                |||.:|...:..::|.:.:.:|.|:...|.:..|
  Rat  1545 -------AARNNWSP----------------PLSPESSPKEGSSESEDERIEICSTDGCPGTPVT 1586

  Fly  1465 TTTTTASATSTVYDEEPKPSLPP-----------PPA---SVPAETLRYVTLHMDKSKNLGIKLF 1515
            ....|..|...|...:.:....|           |.|   |:|..:..:..|             
  Rat  1587 APPPTQVALCPVLPVQQRAVCKPVGDICERACFVPGASRTSIPDSSQPFSFL------------- 1638

  Fly  1516 GGNKVGIYVHDVAVGSPSDHAGIRKGDQILEY--NGV-DLSGVTAEQAANEISKLTDTVTMLVQN 1577
                      ||:...|...|.|......:..  .|: |::..::....::.|::|         
  Rat  1639 ----------DVSSEEPETWASINASQNHMPVCTEGIMDVTSTSSNMGDSQSSQMT--------- 1684

  Fly  1578 KLHTLKQIKDEPGDSFYIRVGFDRTGELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGH 1642
                 :..::.|    ::....|...:|..|.|    ||                        |.
  Rat  1685 -----RHCRNAP----FVLGNPDMVNDLGRDLL----DE------------------------GA 1712

  Fly  1643 RKECGIIPSQMKV-----EEELRSGEVVDCDTGTARRGS---------TSARR---SFFR--RKK 1688
            .||.....|.|:.     .|..::||.|..|...|.||:         |.:||   ::|:  .|.
  Rat  1713 PKEGAAAASVMRSVFALGAEGPKNGEAVLADLHIAERGNLEDLLQKPKTISRRPILTWFKEINKD 1777

  Fly  1689 NQRSSSRDSTE 1699
            :|.|..|.::|
  Rat  1778 SQGSHLRSTSE 1788

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dlg5NP_609505.1 AAA_23 <165..333 CDD:290211 37/173 (21%)
CENP-F_leu_zip 229..360 CDD:287450 27/135 (20%)
DUF1090 <326..408 CDD:284007 15/94 (16%)
PDZ_signaling 439..516 CDD:238492 20/111 (18%)
PDZ_signaling 533..592 CDD:238492 16/58 (28%)
PDZ_signaling 1290..1369 CDD:238492 10/78 (13%)
PDZ_signaling 1497..1576 CDD:238492 10/81 (12%)
SH3_DLG5 1594..1657 CDD:212794 11/67 (16%)
Guanylate_kin 1737..1904 CDD:279019
NK <1773..1905 CDD:302627
Pdzd2XP_038959013.1 PDZ_signaling 335..416 CDD:238492 14/80 (18%)
PDZ_signaling 590..671 CDD:238492 23/90 (26%)
PDZ_signaling 729..813 CDD:238492 12/83 (14%)
PHA03247 <985..1446 CDD:223021 113/541 (21%)
PDZ_signaling 2603..2677 CDD:238492
PDZ_signaling 2731..2813 CDD:238492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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