DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and PALS1

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_071919.2	Gene:	PALS1 / 64398	HGNCID:	18669	Length:	675	Species:	Homo sapiens

Alignment Length:	595	Identity:	106/595 - (17%)
Similarity:	234/595 - (39%)	Gaps:	107/595 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1359 QCGDSFTMLVQYNPEKFPSIEYEGAHNLEPESPINHSGSPTPRNSPRPPARNSLFPLPMQPQ--A 1421
            |..:..::|:|....|    :::.|..:       |:......|...||     |||....|  |
Human   142 QSQEDISLLLQLVQNK----DFQNAFKI-------HNAITVHMNKASPP-----FPLISNAQDLA 190

  Fly  1422 PSTRPGSRAPLSHQSIKDQSFTDSLEN--------QSDISSSQDMPSSAATTTTTTASATSTVYD 1478
            ...:...: |:.|:  :.|..|..|..        ..|..:.|:|.....|             |
Human   191 QEVQTVLK-PVHHK--EGQELTALLNTPHIQALLLAHDKVAEQEMQLEPIT-------------D 239

  Fly  1479 EEPKPSLPPPPASVPAETLRYVTLHMDKSKNLGIKLFGGNKV-GIYVHDVAVGSPSDHAG-IRKG 1541
            |....|:    .....||::.|  .::|::::.:.....|:: .:.:..:..|..::.:| :.:|
Human   240 ERVYESI----GQYGGETVKIV--RIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEG 298

  Fly  1542 DQILEYNGVDLSGVTAEQAANEISKLTDTVTMLVQNKLHTLKQIKDEPGDSFYIRV----GFDRT 1602
            |::||.||:::.|....:..:.:|.:..|:|.:    |...:|||..|.....|.|    .:|.:
Human   299 DEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFV----LIPSQQIKPPPAKETVIHVKAHFDYDPS 359

  Fly  1603 GE----LNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRKECGIIPSQMKVEEELRSGE 1663
            .:    ..|..|.|.|.::|:|   :.......|:|::.....::...|::|.:...::.....:
Human   360 DDPYVPCRELGLSFQKGDILHV---ISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQ 421

  Fly  1664 VVDCDTGTARRGST-SARRSFFRRKKNQRSSSRDSTEIASFSNTQLSFFPDLGLLNDDGGALSYQ 1727
            .::.|....:.|.. .|:::..:|||...:::::.    .:.|.::               |:|:
Human   422 TIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKND----DYDNEEI---------------LTYE 467

  Fly  1728 RVELLDSPI--RRPVLIIGPLSEC----LMVRLTIDFSNLFKLC-----------EVTAMD---C 1772
            .:.|...|.  :||:::||| ..|    |..||.....:.|...           ||...|   .
Human   468 EMSLYHQPANRKRPIILIGP-QNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFV 531

  Fly  1773 SQEAMEEGLKENIFVDYRRRGNKFECTTVEAISNACKNDRRHCILDVSISAVERLQRLQIYPIVL 1837
            |::|.|..:....|:::.........|:::::.... |..:.|:|.:...:::.|:...:.|.::
Human   532 SRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVI-NSGKICLLSLRTQSLKTLRNSDLKPYII 595

  Fly  1838 LLRFKSAKQIRDIRDFGTDKISAKAAKEMYERAMKLETDYKQYISAVIPGVSIKHMCTQIKDAVD 1902
            .:...|.:::|.:..........:..:|:.|:..::|.:...|....|....:.....::...::
Human   596 FIAPPSQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLIN 660

  Fly  1903 KEQDKLLWVP 1912
            |...:..|||
Human   661 KLDTEPQWVP 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	2/9 (22%)
		PDZ_signaling	1497..1576	CDD:238492	15/80 (19%)
		SH3_DLG5	1594..1657	CDD:212794	13/70 (19%)
		Guanylate_kin	1737..1904	CDD:279019	30/184 (16%)
		NK	<1773..1905	CDD:302627	18/131 (14%)
PALS1	NP_071919.2	Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions. /evidence=ECO:0000250\|UniProtKB:Q9JLB2	1..345		48/244 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		Interaction with PARD6B. /evidence=ECO:0000250\|UniProtKB:Q9JLB2	21..140
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..78
		L27_N	123..170	CDD:401122	6/38 (16%)
		Interaction with LIN7C. /evidence=ECO:0000250\|UniProtKB:Q9JLB2	181..243		15/77 (19%)
		L27	189..237	CDD:197794	9/50 (18%)
		PDZ_signaling	254..333	CDD:238492	15/84 (18%)
		SH3_MPP5	349..411	CDD:212969	12/64 (19%)
		GuKc	491..661	CDD:214504	24/170 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810