Protein Alignment Dlg5 and Dlg2

DIOPT Version :10

• Sequence 1: NP_609505.1
• Gene: Dlg5 / 34573
• FlyBaseID: FBgn0032363
• Length: 1916
• Species: Drosophila melanogaster
• Sequence 2: XP_038945240.1
• Gene: Dlg2 / 64053
• RGDID: 619895
• Length: 1026
• Species: Rattus norvegicus
• Alignment Length: 1101
• Identity: 253/1101 - (22%)
• Similarity: 423/1101 - (38%)
• Gaps: 306/1101 - (27%)

  Fly   982 DVVSLKSQNSIESILSAKSPAISEYGMYAKRHVPQAVRHVPKYPSDSESIGSGVHGGYGGFLQSN 1046
            :|..|.||.|.|.       .|.|....|::.....|..:.:   ||....|.:.|..|....::
  Rat    57 EVTLLNSQKSCEQ-------KIEEANQVAQKWEKTLVLDLCR---DSLQKSSELTGCSGPKENAS 111

  Fly  1047 HMPGNRHTQLFPTFGPGGRGNRRSSPLTLPSPPPQQQLQQLPAATAPHDSVGIPTDLDYHPHHHT 1111
            ::..|:..|.|                  .:...::..|......|.:.||..|.   :.|.||.
  Rat   112 YIEQNKENQFF------------------ENETEEKTCQNQGKCPAQNCSVEAPA---WMPVHHC 155

  Fly  1112 -----QTNAMPHPHPHPHAPYLDYGHGLGIGPYMGVGGGVSGVGGAIYEGGTFPRKKDNQRLRIP 1171
                 |....||.|..|...:                                       .:|.|
  Rat   156 SKYRYQDEDGPHDHSLPRLTH---------------------------------------EVRGP 181

  Fly  1172 SNPSVASKSSSMVKNSSGSIDHHYVT----STGPVSGGSMSASSSDRAPM-----------SLMS 1221
            ....|:.|:.|.::|..|.:...:::    |..|:   .::..:.|..|.           .:..
  Rat   182 ELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPI---IVNTDTLDTIPYVNGTEIEYEFEEITL 243

  Fly  1222 SSIHNSYGANIAGGNGT---GSSIG------VGGGGGGGSGRGS------PMPQVHVEVLSHGGG 1271
            ...::..|.:||||...   |...|      :.||.....||..      .:.:|.|..:||...
  Rat   244 ERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKA 308

  Fly  1272 GSGKRNSNVPADFLCPGDLRRVTIDKR---------------DKSLGITIQCNNNGG-------- 1313
            ....:.:         |.:.|:.:.:|               .|.||.:|.    ||
  Rat   309 VEALKEA---------GSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIA----GGVGNQHIPG 360

  Fly  1314 --GIFVSTVADKSTAMRAG-LQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLVQYNPEKF 1375
              .|:|:.:.|...|.:.| |||||:||.|...::...|.|.|..:|:...|     |.|.....
  Rat   361 DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSD-----VVYLKVGK 420

  Fly  1376 PSIEYEGAHNLEPESP--INHSGSPTPRN----------------SPRPPARNSLFPLPMQPQAP 1422
            |:..|    ..:|..|  |.||.||...|                .|..|.|.|..|..|..:..
  Rat   421 PTTIY----MTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVEDD 481

  Fly  1423 STRPGS-------------RAPLSHQSIK-DQSFTDS---------LENQSDISSSQDMPSSAAT 1464
            .|||..             .:|..:..:: |:||..|         |...||::|.....::...
  Rat   482 YTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSTPYPHYHLGLLPDSDMTSHSQHSTATRQ 546

  Fly  1465 TTTTTASATSTVYDEEPKPSLPPPPASVPAETLRYVTLHMDKSKNLGIKLFGG-NKVGIYVHDVA 1528
            .:.|...|.|  .:.||                |.|.||.. |..||..:.|| :..||:|..:.
  Rat   547 PSVTLQRAIS--LEGEP----------------RKVVLHKG-STGLGFNIVGGEDGEGIFVSFIL 592

  Fly  1529 VGSPSDHAG-IRKGDQILEYNGVDLSGVTAEQAANEISKLTDTVTMLVQ----------NKLHTL 1582
            .|.|:|.:| :::|||||..||:||.|.:.||||..:.....|||::.|          .|:|.|
  Rat   593 AGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDL 657

  Fly  1583 KQ-------------IKDEPGDSFYIRVGFD----RTGELNEDDLRFVKDEVLYVDNTVFNGTFG 1630
            ::             ::.....|.|:|..||    :...|....|.|...::|:|.|.   ....
  Rat   658 REQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINA---SDDE 719

  Fly  1631 LWRAWKLDAMGHRKECGIIPSQMKVEEELRS----------GEVVDCDTGTARRGSTSARR--SF 1683
            .|:|.::...|..:|.|:|||:.:||.:.|:          ..|:|      .:||.:.:|  ||
  Rat   720 WWQARRVILDGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVID------SKGSFNDKRKKSF 778

  Fly  1684 -FRRK----KNQRSSSRDSTE-------IASFSNTQLSFFPDLGLLNDDGGALSYQRVELLDSPI 1736
             |.||    ||:..|.:::::       .||.|.:......||        .|||:.|...:...
  Rat   779 IFSRKFPFYKNKEQSEQETSDPEQHVSSNASDSESSCRGQEDL--------ILSYEPVTRQEINY 835

  Fly  1737 RRPVLIIGPLSECLMVRLTIDFSNLFKLC-----------EVTAMD----CSQEAMEEGLKENIF 1786
            .|||:|:||:.:.:...|..:|.:.|..|           ||...|    .|:|.||:.::|:.|
  Rat   836 TRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKF 900

  Fly  1787 VDYRRRGNKFECTTVEAISNACKNDRRHCILDVSISAVERLQRLQIYPIVLLLRFKSAKQIRDIR 1851
            ::..:..:....|:|:::....:.. :|||||||.:|::|||..|:|||.:.::.||.:.:.::
  Rat   901 IEAGQYNDNLYGTSVQSVRFVAERG-KHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEM- 963

  Fly  1852 DFGTDKISAKAAKEMYERAMKLETDYKQYISAVIPGVSIKHMCTQIKDAVDKEQDKLLWVP 1912
               ..:::.:.||:.|:||:|||.::.:|.:|::.|.:::.:..|.|..::::....:|:|
  Rat   964 ---NKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 1021

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	COG1340	176..>416	CDD:440951
		PDZ_canonical	441..516	CDD:467153
		PDZ_canonical	540..609	CDD:483948
		PDZ3_DLG5-like	1288..1370	CDD:467248	28/107 (26%)
		PDZ_canonical	1498..1576	CDD:483948	33/79 (42%)
		SH3_DLG5	1594..1657	CDD:212794	19/66 (29%)
		NK	<1773..1905	CDD:450170	38/131 (29%)
Dlg2	XP_038945240.1	L27_1	7..64	CDD:462665	2/6 (33%)
		MAGUK_N_PEST	157..239	CDD:431391	16/123 (13%)
		PDZ1_Dlg1-2-4-like	238..326	CDD:467206	17/96 (18%)
		PDZ2_Dlg1-2-4-like	335..419	CDD:467207	26/92 (28%)
		PDZ_assoc	420..487	CDD:463164	19/70 (27%)
		PDZ3_Dlg1-2-4-like	560..650	CDD:467257	36/106 (34%)
		SH3_DLG2	676..749	CDD:212965	21/75 (28%)
		Guanylate_kin	835..1013	CDD:395500	51/182 (28%)