DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dlg5 and Dlg2

DIOPT Version :9

Sequence 1:NP_609505.1 Gene:Dlg5 / 34573 FlyBaseID:FBgn0032363 Length:1916 Species:Drosophila melanogaster
Sequence 2:XP_038945240.1 Gene:Dlg2 / 64053 RGDID:619895 Length:1026 Species:Rattus norvegicus


Alignment Length:1091 Identity:251/1091 - (23%)
Similarity:422/1091 - (38%) Gaps:286/1091 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   982 DVVSLKSQNSIESILSAKSPAISEYGMYAKRHVPQAVRHVPKYPSDSESIGSGVHGGYGGFLQSN 1046
            :|..|.||.|.|.       .|.|....|::.....|..:.:   ||....|.:.|..|....::
  Rat    57 EVTLLNSQKSCEQ-------KIEEANQVAQKWEKTLVLDLCR---DSLQKSSELTGCSGPKENAS 111

  Fly  1047 HMPGNRHTQLFPTFGPGGRGNRRSSPLTLPSPPPQQQLQQLPAATAPHDSVGIPTDLDYHPHHHT 1111
            ::..|:..|.|                  .:...::..|......|.:.||..|.   :.|.||.
  Rat   112 YIEQNKENQFF------------------ENETEEKTCQNQGKCPAQNCSVEAPA---WMPVHHC 155

  Fly  1112 -----QTNAMPHPHPHPHAPYLDYGHGLGIGPYMGVGGGVSGVGGAIYEGGTFPRKKDNQRLRIP 1171
                 |....||.|..|...:                                       .:|.|
  Rat   156 SKYRYQDEDGPHDHSLPRLTH---------------------------------------EVRGP 181

  Fly  1172 SNPSVASKSSSMVKNSSGSIDHHYVT----STGPVSGGSMSASSSDRAPM-----------SLMS 1221
            ....|:.|:.|.::|..|.:...:::    |..|:   .::..:.|..|.           .:..
  Rat   182 ELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPI---IVNTDTLDTIPYVNGTEIEYEFEEITL 243

  Fly  1222 SSIHNSYGANIAGGNGT---GSSIG------VGGGGGGGSGRGS------PMPQVHVEVLSHGGG 1271
            ...::..|.:||||...   |...|      :.||.....||..      .:.:|.|..:||...
  Rat   244 ERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKA 308

  Fly  1272 GSGKRNSNVPADFLCPGDLRRVTIDKR---------------DKSLGITIQCNNNGG-------- 1313
            ....:.:         |.:.|:.:.:|               .|.||.:|.    ||        
  Rat   309 VEALKEA---------GSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIA----GGVGNQHIPG 360

  Fly  1314 --GIFVSTVADKSTAMRAG-LQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLVQYNPEKF 1375
              .|:|:.:.|...|.:.| |||||:||.|...::...|.|.|..:|:...|     |.|.....
  Rat   361 DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSD-----VVYLKVGK 420

  Fly  1376 PSIEYEGAHNLEPESP--INHSGSPTPRNSPRPPARNSLF-----PLPMQPQAPSTRPGSRAPLS 1433
            |:..|    ..:|..|  |.||.|        ||..|.|.     .|..:...|...||..:|:.
  Rat   421 PTTIY----MTDPYGPPDITHSYS--------PPMENHLLSGNNGTLEYKTSLPPISPGRYSPIP 473

  Fly  1434 HQSIKDQSFTDSLEN-QSDISSSQDMPSSAATTTTTTASAT---STVYDEEPKPSLPPPPAS--- 1491
            ...:.:..:|...|. .|.::...|.|:|....:......:   ||.|.......||....:   
  Rat   474 KHMLVEDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSTPYPHYHLGLLPDSDMTSHS 538

  Fly  1492 -------VPAETL----------RYVTLHMDKSKNLGIKLFGG-NKVGIYVHDVAVGSPSDHAG- 1537
                   .|:.||          |.|.||.. |..||..:.|| :..||:|..:..|.|:|.:| 
  Rat   539 QHSTATRQPSVTLQRAISLEGEPRKVVLHKG-STGLGFNIVGGEDGEGIFVSFILAGGPADLSGE 602

  Fly  1538 IRKGDQILEYNGVDLSGVTAEQAANEISKLTDTVTMLVQ----------NKLHTLKQ-------- 1584
            :::|||||..||:||.|.:.||||..:.....|||::.|          .|:|.|::        
  Rat   603 LQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMS 667

  Fly  1585 -----IKDEPGDSFYIRVGFD----RTGELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAM 1640
                 ::.....|.|:|..||    :...|....|.|...::|:|.|.   .....|:|.::...
  Rat   668 SGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINA---SDDEWWQARRVILD 729

  Fly  1641 GHRKECGIIPSQMKVEEELRS----------GEVVDCDTGTARRGSTSARR--SF-FRRK----K 1688
            |..:|.|:|||:.:||.:.|:          ..|:|      .:||.:.:|  || |.||    |
  Rat   730 GDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVID------SKGSFNDKRKKSFIFSRKFPFYK 788

  Fly  1689 NQRSSSRDSTE-------IASFSNTQLSFFPDLGLLNDDGGALSYQRVELLDSPIRRPVLIIGPL 1746
            |:..|.:::::       .||.|.:......||        .|||:.|...:....|||:|:||:
  Rat   789 NKEQSEQETSDPEQHVSSNASDSESSCRGQEDL--------ILSYEPVTRQEINYTRPVIILGPM 845

  Fly  1747 SECLMVRLTIDFSNLFKLC-----------EVTAMD----CSQEAMEEGLKENIFVDYRRRGNKF 1796
            .:.:...|..:|.:.|..|           ||...|    .|:|.||:.::|:.|::..:..:..
  Rat   846 KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNL 910

  Fly  1797 ECTTVEAISNACKNDRRHCILDVSISAVERLQRLQIYPIVLLLRFKSAKQIRDIRDFGTDKISAK 1861
            ..|:|:::....:.. :|||||||.:|::|||..|:|||.:.::.||.:.:.::    ..:::.:
  Rat   911 YGTSVQSVRFVAERG-KHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEM----NKRLTEE 970

  Fly  1862 AAKEMYERAMKLETDYKQYISAVIPGVSIKHMCTQIKDAVDKEQDKLLWVP 1912
            .||:.|:||:|||.::.:|.:|::.|.:::.:..|.|..::::....:|:|
  Rat   971 QAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 1021

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dlg5NP_609505.1 AAA_23 <165..333 CDD:290211
CENP-F_leu_zip 229..360 CDD:287450
DUF1090 <326..408 CDD:284007
PDZ_signaling 439..516 CDD:238492
PDZ_signaling 533..592 CDD:238492
PDZ_signaling 1290..1369 CDD:238492 26/104 (25%)
PDZ_signaling 1497..1576 CDD:238492 34/90 (38%)
SH3_DLG5 1594..1657 CDD:212794 19/66 (29%)
Guanylate_kin 1737..1904 CDD:279019 51/181 (28%)
NK <1773..1905 CDD:302627 38/131 (29%)
Dlg2XP_038945240.1 L27_1 2..62 CDD:401120 1/4 (25%)
MAGUK_N_PEST 157..239 CDD:402306 16/123 (13%)
PDZ_signaling 240..324 CDD:238492 17/92 (18%)
PDZ_signaling 333..418 CDD:238492 26/93 (28%)
PDZ_assoc 420..487 CDD:402299 18/78 (23%)
PDZ_signaling 561..639 CDD:238492 33/78 (42%)
SH3_DLG2 676..749 CDD:212965 21/75 (28%)
Guanylate_kin 835..1013 CDD:395500 51/182 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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