DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and Dlg3

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	XP_006257142.1	Gene:	Dlg3 / 58948	RGDID:	68423	Length:	867	Species:	Rattus norvegicus

Alignment Length:	1020	Identity:	227/1020 - (22%)
Similarity:	387/1020 - (37%)	Gaps:	303/1020 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1009 YAKRHVPQAVRHVPKYPSDSESIGSGVHGGYGGFLQSNHMPG--------NRHTQLFPTFGPGGR 1065
            |....||.     |..||.    |:|...||||: .|..:|.        ....:|.||
  Rat    30 YGDWQVPD-----PYGPSG----GNGASSGYGGY-SSQTLPSQAGATPTPRTKAKLIPT------ 78

  Fly  1066 GNRRSSPLTLPSPPPQQQLQQL--------PAATAPHDSVGIPTDLDYHPHHHTQTNAMPHP--- 1119
             .|...|:. |.|.|.:...:|        |..|.        |:.|::      ..|.|.|
  Rat    79 -GRDVGPVP-PKPVPGKNTPKLNGSGPSWWPECTC--------TNRDWY------EQASPAPLLV 127

  Fly  1120 HPHPHAPYLDYGHGLGIGPY--MGVGGGVSGVGGAIYEGGTFPRKKDNQRLRIPSNPSVASKSSS 1182
            :|....|.|......|:..|  :.:..|.||:|.:| .||.     ||.  .:|.:|.:.  .:.
  Rat   128 NPEALEPSLSVNGSDGMFKYEEIVLERGNSGLGFSI-AGGI-----DNP--HVPDDPGIF--ITK 182

  Fly  1183 MVKNSSGSIDHHY-------------------------VTSTGPVSGGSMSASSSDRAPMSLMSS 1222
            ::...:.::|...                         :...|||.  .:........|.::|..
  Rat   183 IIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVV--RLVVRRRQPPPETIMEV 245

  Fly  1223 SIHNSYGANIAGGNGTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCP 1287
            ::       :.|..|.|.||                           .||.|  |.::|.|
  Rat   246 NL-------LKGPKGLGFSI---------------------------AGGIG--NQHIPGD---- 270

  Fly  1288 GDLRRVTIDKRDKSLGITIQCNNNGGGIFVSTVADKSTAMRAG-LQVGDQLLEVCGINMRAATQE 1351
                                     ..|:::.:.:...|.:.| ||:||:||.|...|::....|
  Rat   271 -------------------------NSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHE 310

  Fly  1352 IAANVLRQCGDSFTMLV----------QYNPEKFPSIEYEGAHN-LEPESPINHSGSPTPRNSPR 1405
            .|...|:...|...:.|          .|.|..:.|.....|.| :...|.:.:.|
  Rat   311 EAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLG--------- 366

  Fly  1406 PPARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTA 1470
              |..|....|..||.|.||   .:|:....:.::.||
  Rat   367 --AVESKVTYPAPPQVPPTR---YSPIPRHMLAEEDFT--------------------------- 399

  Fly  1471 SATSTVYDEEPKPSLPPPPASVPAETLRYVTLHMDKSKNLGIKLFGG-NKVGIYVHDVAVGSPSD 1534
                    .||                |.:.||.. |..||..:.|| :..||:|..:..|.|:|
  Rat   400 --------REP----------------RKIILHKG-STGLGFNIVGGEDGEGIFVSFILAGGPAD 439

  Fly  1535 HAG-IRKGDQILEYNGVDLSGVTAEQAANEISKLTDTVTMLVQ----------NKLHTLKQ---- 1584
            .:| :|:||:||..|||:|...|.||||..:.:...:||::.|          :|:|.|::
  Rat   440 LSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMN 504

  Fly  1585 ---------IKDEPGDSFYIRV--GFDRTGE--LNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWK 1636
                     ::.....|.|:|.  .:|||.:  |....|.|...::|:|.|.   .....|:|..
  Rat   505 SSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINA---SDDEWWQARL 566

  Fly  1637 LDAMGHRKECGIIPSQMKVEEE-----------LRSGEVVDCDTG--TARRGSTSARRSF-FRRK 1687
            :...|..::.|:|||:.:||::           .|:| :::.:..  |.|:.|....|.| |.:.
  Rat   567 VTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTG-MIESNRSIKTKRKKSFRLSRKFPFYKS 630

  Fly  1688 KNQRSSSRDSTEIASFSNTQLSFFPDLGLLNDDGGALSYQRVELLDSPIRRPVLIIGPLSECLMV 1752
            |...:..:...|....|||..|.....|   .:...|||:.|...:....|||:|:||:.:.:..
  Rat   631 KENMAQEKSIQEQGVTSNTSDSESSSKG---QEDAILSYEPVTRQEIHYARPVIILGPMKDRVND 692

  Fly  1753 RLTIDFSNLFKLC-----------EVTAMD----CSQEAMEEGLKENIFVDYRRRGNKFECTTVE 1802
            .|..:|.:.|..|           ||...|    .|:|.||:.:::|.|::..:..:....|:::
  Rat   693 DLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQ 757

  Fly  1803 AISNACKNDRRHCILDVSISAVERLQRLQIYPIVLLLRFKSAKQIRDIRDFGTDKISAKAAKEMY 1867
            :: .|.....:|||||||.:|::|||:.|:|||.:.::.||.:.:.::    ..:.:.:.|.:::
  Rat   758 SV-RAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEM----NRRQTYEQANKIF 817

  Fly  1868 ERAMKLETDYKQYISAVIPGVSIKHMCTQIKDAVDKEQDKLLWVP 1912
            ::|||||.::.:|.:|::.|.|::.:..:||..::.:....:|||
  Rat   818 DKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVP 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	16/89 (18%)
		PDZ_signaling	1497..1576	CDD:238492	31/80 (39%)
		SH3_DLG5	1594..1657	CDD:212794	19/66 (29%)
		Guanylate_kin	1737..1904	CDD:279019	50/181 (28%)
		NK	<1773..1905	CDD:302627	37/131 (28%)
Dlg3	XP_006257142.1	MAGUK_N_PEST	52..148	CDD:287565	24/118 (20%)
		PDZ_signaling	149..226	CDD:238492	12/86 (14%)
		PDZ_signaling	242..328	CDD:238492	27/150 (18%)
		PDZ_assoc	329..403	CDD:287558	20/138 (14%)
		PDZ_signaling	402..480	CDD:238492	32/94 (34%)
		SH3_DLG3	520..586	CDD:212962	19/68 (28%)
		Guanylate_kin	676..854	CDD:279019	50/182 (27%)
		GuKc	687..854	CDD:214504	44/171 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810