Protein Alignment Dlg5 and dlg5a

DIOPT Version :10

• Sequence 1: NP_609505.1
• Gene: Dlg5 / 34573
• FlyBaseID: FBgn0032363
• Length: 1916
• Species: Drosophila melanogaster
• Sequence 2: XP_068069011.1
• Gene: dlg5a / 569065
• ZFINID: ZDB-GENE-030131-3149
• Length: 1987
• Species: Danio rerio
• Alignment Length: 2224
• Identity: 569/2224 - (25%)
• Similarity: 885/2224 - (39%)
• Gaps: 660/2224 - (29%)

  Fly    10 SLTSTSSQEEESSEYVGYDNT-----------LRPPSNS-------------------------S 38
            |:.||...:.|||..:....|           .||.|:|                         |
Zfish   105 SVLSTMPSDSESSSSLSSVGTKASSPPPALSDTRPASDSLDTILFQLKQVTRERDELRKRLALAS 169

  Fly    39 GSTTAANMSNNNGPSKGVSSGVGVSGISGGNGANYDILQAQYKSALLELNTLRHQHANTKRRCDE 103
            ..||..:...|:.|                 |.:|:.|:.|...|:.:|.:|::||..|.:||:|
Zfish   170 PGTTFDDCRPNSKP-----------------GHDYERLKTQCTKAMADLQSLQNQHTKTLKRCEE 217

  Fly   104 --------------LATELTLYQEHYVADRNKFTDMVEESARFK-------RLLLETQNQ----- 142
                          |.:|.|..:|.....:.:.|.:..|....|       ||..|.|.:
Zfish   218 AVKEADYYHIQHSRLLSEQTQLKEEMEVLKRENTKLTREHNHLKQSCEELRRLHSEDQREVADMR 282

  Fly   143 -QSQQA--QNGNSQV---------------------------PPVGSGN---------------- 161
             |.||.  :||:|:|                           ..|.|.|
Zfish   283 LQQQQVIRENGSSEVLNKLYDTAMDKLEGVKKEYDVLSKRYSEKVSSHNTDLSRLEQVEEENRRL 347

  Fly   162 ---------------PYY---------FGKTQGCDGSCSEKLAELKKERNMVAVEREKYKKSYIE 202
                           .|.         |...|......|.:..||::|...:..|..:||...::
Zfish   348 QKQIDALLKQRDTAIQYQQQWSTSMRRFDSVQQELNKASAQNKELQREMERLQSEVTRYKNFQLK 412

  Fly   203 LEKDRNYYRERGD------------------ENQKLKVLL----------SQE----SKNVLSLT 235
            ..||...|:|..|                  |..||:..|          |.|    |:.:.:|.
Zfish   413 AVKDGEKYKEERDSVFNEYRLIMSERDQVIKEVDKLQTELEAAEARLKNTSSERMVASEELEALR 477

  Fly   236 EELNQLLSEKDNVLQEHQKMSD-------DLVLANKEIERLKKDEQLARAEIKVL--QLANADLK 291
            :|||..|.::|..:.|..::.:       |...|.||:.:..||.:..|.|..|.  :...|.::
Zfish   478 QELNSSLVDRDRAICERNELLEKYCHEVKDKAEAQKELSQACKDIETVREERDVARKERTEAIIQ 542

  Fly   292 KRDLLKSRDSSWSKEFPSGKELEN-SKELEKLRKSLEKALSEVERSSQDAEEAKRVRDWAISQRE 355
            :..||:....:..|:..:..::|. :||::.|||..|....|::.:.|:||.||..||||..:|:
Zfish   543 RDQLLREYYQARQKQDSATLDMERANKEIDILRKQCEAMSQELKEAVQEAEVAKCRRDWAFQERD 607

  Fly   356 KIVQERDSVKTLCDKMRHERDKAISDSLMAIRDSEKIKKQKDEAQKKIDLLKEQMEQQERQNLDS 420
            |||.||:|::||||.:|.|||:|:||...|:|:.:.::||:::|.:::..|||:||.|    ||.
Zfish   608 KIVAERESIRTLCDNLRRERDRAVSDLADALRNLDDMRKQRNDAARELKELKEKMESQ----LDK 668

  Fly   421 NASGSR---RSFRPSSYEGEDL-LEVELSGYEHTSD------LGI-ILDDSNKRKLV--CG---- 468
            .|...:   .|...|:.:.:.| .|.|:..:|...|      :|. |.:..|...|.  ||
Zfish   669 EARFCQLMAHSSHDSAIDTDSLEWETEVVEFEKDRDDMDLKAMGFDIAEGVNDPYLPGDCGIFVS 733

  Fly   469 -VTSSSPACGKLKINDVICKVNNLDCQSLSKRMVLDEIRACAPRSLL-------LVSRTRHS--K 523
             |...|.|.|:|::||.:.|:|::|..:..::.|:        :::|       :|.|.|.|  .
Zfish   734 RVDKGSIADGRLRVNDWLLKINDVDLTNKDRKQVI--------KAVLNGGGLINMVVRRRKSLGG 790

  Fly   524 RHAYSVQLK-TRDRDCPHGLQLDMGVFIAKIEQNSLAFYEPELDVGDRVLSINNKSMDSVQSIEE 587
            |...||.:. ...:|.  |:.|:.|||:|.|...|.|..|..|.:|||:::||..::|: :|:.|
Zfish   791 RLVTSVHINLIGHKDA--GIALEGGVFVAGIAPGSPAAREGSLTIGDRLIAINGIALDN-KSLSE 852

  Fly   588 VMQLMNDPRSDGLNLFALKYVQDQLPPGMTTSSAQTDSIDSMQHVSSAGG-----GGGSGPSSAT 647
            ...|:...| |.|.|..:|:        ...|::..:..:|::....:.|     ...|..|...
Zfish   853 CEALLRGGR-DSLALSLMKF--------FPQSTSGQNIFESLREAEKSNGRIHLTDVHSRNSRNL 908

  Fly   648 KHPSRFAEFFF--------RKLKFSKPGTPEDNFEQEHDDAIAALDSVLSENSSE----KSKENL 700
            ||.|......:        ||   ::....|..|.:.....|:.|.......:||    :...:.
Zfish   909 KHNSSTQTDIYSCDTAGERRK---TRSDAEESLFSERKVFPISTLHPNTLRPASELGPVRYSASA 970

  Fly   701 FNRKKRTKKEK------------EASKSMGTWPR----TNISHENPT--GTMRGNEKKRALMSLF 747
            |.....|:.|.            |...|.||||:    ..::.::|.  ...|..::::::.
Zfish   971 FQEVCYTRSESVGPECVTLETTLEKKHSGGTWPKMVVGVAMTTDSPAQLSIYRSPKQRKSIF--- 1032

  Fly   748 TAGPINVDKDDELMGEVGVPEKQ----PAALIQDQLP-PPLPPQMSKPLAHIRGSNGGAIKTHPN 807
                     |.:.......|.|.    |..|..|..| ||.||..|.....          .|.:
Zfish  1033 ---------DADTFKRPDTPSKADYHGPQPLKADSAPTPPTPPTRSDSFKF----------KHKH 1078

  Fly   808 RNSNPVSSGVSALFPPGPP----NGMPNTSYPTHPRHSLY-----GVTAEEINQKPIQRAPLMGA 863
            :.|:...|.:||:....|.    ||            :||     .:::.:..::.|.|  :...
Zfish  1079 QGSSTSESTISAMSISEPKQEDRNG------------NLYFSEGKVLSSRKSCEEDIGR--MWAE 1129

  Fly   864 NARVKMPSQERYGTRPHSNHRLSLNITPSG----DFYQPKTSGQQAQQQVMNASST------SAG 918
            ...||.|       ||.|...|...:||..    .|......|...:|:.|..||.      |.|
Zfish  1130 EPEVKRP-------RPKSAPALRRRMTPQNIPLQSFQSYSNDGDSVEQREMLRSSPNRPHRHSVG 1187

  Fly   919 FGVGS-------GSMVGGTGPAAGEFPVRKQQVYDV----FHPPPLPKNSSGSNMFMPLHPTRGS 972
            |...|       .|...|..|.:....|.|..||.|    .|....|...|..|.       :.:
Zfish  1188 FVPTSYNGTLPPNSAHRGLAPCSAVTAVMKNPVYMVRSHRVHTNNCPTVVSQINQ-------QHT 1245

  Fly   973 HPPPVGQPPDVVSLKSQNSIESILSAKSPAISEYGMYAKRHVPQAVRHVPKYPSDSESIGSGVHG 1037
            ||.|..|....:.|..:.|.:...|::|...|                               ||
Zfish  1246 HPSPQHQGQLSLDLSQKRSTDYSESSRSSRAS-------------------------------HG 1279

  Fly  1038 GYGGFLQSNHMPGNRHTQLFPTFGPGGRGNRRSSPLTLPSPPPQQQLQQLPAATAPHDSVGIPTD 1102
                   :|.:|.:..                                           :|...:
Zfish  1280 -------TNSLPSSAR-------------------------------------------LGSSNN 1294

  Fly  1103 LDYHPHHHTQTNAMPHPHPHPHAPYLDYGHGLGIGPYMGVGGGVSGVGGAIYEGGTFPRKKDNQR 1167
            |.|.                                                          .:|
Zfish  1295 LQYR----------------------------------------------------------TER 1301

  Fly  1168 LRIPSNPSVASKSSSMVKNSSGSIDHHYVTS----TGPVSGGSMSASSSDRAPMSLMSSSIHNSY 1228
            ::|||.|..   ..|::.:..||:.|...:|    |.|:|            |::|.:||..:|.
Zfish  1302 IKIPSTPRY---PRSILGSDRGSLSHSECSSPSLITPPLS------------PLNLETSSFASSQ 1351

  Fly  1229 GANIAGGNGTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPAD---------- 1283
                                  ..|..|.:|::.|              |.||.:
Zfish  1352 ----------------------SQGSISTLPRISV--------------SPVPTEERRKDRSLYR 1380

  Fly  1284 ---FL----------CP--------GDLRRVTIDKRDKSLGITIQCNNNGGGIFVSTVADKSTAM 1327
               ||          |.        .:.|.|.:.|..:.|||:|....| ||||||.|...|.|.
Zfish  1381 NRSFLRIPLAARPKFCSLRSLRPYLEEPRNVMVHKGAEPLGISIVSGEN-GGIFVSKVTGGSIAH 1444

  Fly  1328 RAGLQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLVQYNPEKFPSIEYEGAHNLEPESPI 1392
            :|||:.||||||..|||:|.||::.|..::.|..|:.|::.||||..:..    |
Zfish  1445 QAGLEYGDQLLEYNGINLRNATEQQARLIIGQQCDTITIMAQYNPHMYQL----G---------- 1495

  Fly  1393 NHSGSPTPRNSPRPPARNSLFPLPMQPQAPSTRP---GSRAPLSHQSIKDQSFTDSLENQSDISS 1454
            |||     |:|.|           ::|.:..:.|   |:..|.:|.:|      |:|..|.:.:.
Zfish  1496 NHS-----RSSSR-----------LEPVSTQSTPQGSGTATPDNHSTI------DTLSEQDEGTL 1538

  Fly  1455 SQDMPSSAATTTTTTASATSTVYDEEPKPSLPPPPASVPAETLRYVTLHMDKSKNLGIKLFGGNK 1519
            :   |||..||.||:.::...:..|..|        .||  ..|.||:...:.: |||:|.|||.
Zfish  1539 T---PSSKQTTPTTSPNSFIRMPSESSK--------KVP--EARLVTVRKTQVE-LGIQLCGGNL 1589

  Fly  1520 VGIYVHDVAVGSPSDHA-GIRKGDQILEYNGVDLSGVTAEQAANEISKLTDTVTMLVQNKLHTLK 1583
            .||:|..:...||:..| .:..||.||||..|::...|.|:|..|:.|..:|||:.||::|....
Zfish  1590 RGIFVERLEDDSPARGADAVVPGDMILEYGSVNMKNKTVEEAYLEMLKPAETVTLRVQHRLDEFN 1654

  Fly  1584 QIKDEPGDSFYIRVGFDRTGELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRKECGI 1648
            |:|..|||.||||..:||..| .|.||.|.||::||||:|:.||.||.|.||:||....:.:.|.
Zfish  1655 QVKGTPGDGFYIRALYDRVAE-TELDLSFKKDDILYVDDTLPNGNFGTWMAWQLDENAQKIQRGQ 1718

  Fly  1649 IPSQMKVEEEL----RSGEVVDCDTGTARRGSTSARRSFFRRK-KNQRSSSRDSTEIASFSNTQL 1708
            |||:..:::|.    ...|:.| :||:::..|.:||||||||| |::||||:|..::.:......
Zfish  1719 IPSKFMMDQEFYRRHSMTELKD-ETGSSKTLSAAARRSFFRRKHKHKRSSSKDGKDVVALDAIST 1782

  Fly  1709 SFFPDLGLLNDDGGALSYQRVELLDSPIRRPVLIIGPLSECLMVRLTIDFSNLFKLCEVTAMDCS 1773
            ...|.|    ||..:|:||||:.:|....|||||:|||.:.:...|..|....|..|.:..|..|
Zfish  1783 DSIPFL----DDCVSLAYQRVQKIDCTSPRPVLILGPLVDPVKDMLVKDSPGKFSRCVLEVMKAS 1843

  Fly  1774 QEAMEEGLKENIFVDYRRRGNKFECTTVEAISNACKNDRRHCILDVSISAVERLQRLQIYPIVLL 1838
            |:|:|.|:|:.:|:||:||...|:.|||.:|:.....| .||:||::..|:|||..:.|||||:.
Zfish  1844 QQAIERGVKDFLFIDYKRRSGHFDVTTVASINEITDKD-CHCLLDIAPHAIERLHSVHIYPIVIF 1907

  Fly  1839 LRFKSAKQIRDIRD--FGTDKISAKAAKEMYERAMKLETDYKQYISAVIPGVSIKHMCTQIKDAV 1901
            :|:|:||||::.:|  :..||:|.|.:||.:|.|.|:|.||.::.:.::.|.:..::||||...|
Zfish  1908 IRYKNAKQIKEQKDPIYLRDKVSQKHSKEQFEIAQKIEQDYSKFFTGIVQGGTFPYICTQIVTIV 1972

  Fly  1902 DKEQDKLLWVPVSS 1915
            |:||.|:||.|:.|
Zfish  1973 DQEQSKVLWTPLGS 1986

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	COG1340	176..>416	CDD:440951	85/281 (30%)
		PDZ_canonical	441..516	CDD:467153	22/95 (23%)
		PDZ_canonical	540..609	CDD:483948	25/68 (37%)
		PDZ3_DLG5-like	1288..1370	CDD:467248	36/81 (44%)
		PDZ_canonical	1498..1576	CDD:483948	31/78 (40%)
		SH3_DLG5	1594..1657	CDD:212794	30/62 (48%)
		NK	<1773..1905	CDD:450170	56/133 (42%)
dlg5a	XP_068069011.1	CARD	9..88	CDD:260018
		Takusan	126..212	CDD:461445	18/102 (18%)
		GAS	203..414	CDD:464001	38/210 (18%)
		Smc	332..>672	CDD:440809	91/343 (27%)
		PDZ1_DLG5-like	691..785	CDD:467245	24/101 (24%)
		PDZ2_DLG5-like	797..873	CDD:467246	26/87 (30%)
		PDZ3_DLG5-like	1406..1487	CDD:467248	36/81 (44%)
		dbPDZ_assoc	1487..1567	CDD:465197	30/128 (23%)
		PDZ4_DLG5-like	1567..1647	CDD:467247	31/80 (39%)
		SH3_DLG5	1665..1727	CDD:212794	30/62 (48%)
		NK	1820..1976	CDD:450170	61/156 (39%)