DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and dlg5a

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	XP_005156738.1	Gene:	dlg5a / 569065	ZFINID:	ZDB-GENE-030131-3149	Length:	1961	Species:	Danio rerio

Alignment Length:	2193	Identity:	569/2193 - (25%)
Similarity:	886/2193 - (40%)	Gaps:	624/2193 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SLTSTSSQEEESSEYVGYDNT-----------LRPPSNS-------------------------S 38
            |:.||...:.|||..:....|           .||.|:|                         |
Zfish   105 SVLSTMPSDSESSSSLSSVGTKASSPPPALSDTRPASDSLDTILFQLKQVTRERDELRKRLALAS 169

  Fly    39 GSTTAANMSNNNGPSKGVSSGVGVSGISGGNGANYDILQAQYKSALLELNTLRHQHANTKRRCDE 103
            ..||..:...|:.|                 |.:|:.|:.|...|:.:|.:|::||..|.:||:|
Zfish   170 PGTTFDDCRPNSKP-----------------GHDYERLKTQCTKAMADLQSLQNQHTKTLKRCEE 217

  Fly   104 --------------LATELTLYQEHYVADRNKFTDMVEESARFK-------RLLLETQNQ----- 142
                          |.:|.|..:|.....:.:.|.:..|....|       ||..|.|.:
Zfish   218 AVKEADYYHIQHSRLLSEQTQLKEEMEVLKRENTKLTREHNHLKQSCEELRRLHSEDQREVADMR 282

  Fly   143 -QSQQA--QNGNSQV---------------------------PPVGSGN---------------- 161
             |.||.  :||:|:|                           ..|.|.|
Zfish   283 LQQQQVIRENGSSEVLNKLYDTAMDKLEGVKKEYDVLSKRYSEKVSSHNTDLSRLEQVEEENRRL 347

  Fly   162 ---------------PYY---------FGKTQGCDGSCSEKLAELKKERNMVAVEREKYKKSYIE 202
                           .|.         |...|......|.:..||::|...:..|..:||...::
Zfish   348 QKQIDALLKQRDTAIQYQQQWSTSMRRFDSVQQELNKASAQNKELQREMERLQSEVTRYKNFQLK 412

  Fly   203 LEKDRNYYRERGD------------------ENQKLKVLL----------SQE----SKNVLSLT 235
            ..||...|:|..|                  |..||:..|          |.|    |:.:.:|.
Zfish   413 AVKDGEKYKEERDSVFNEYRLIMSERDQVIKEVDKLQTELEAAEARLKNTSSERMVASEELEALR 477

  Fly   236 EELNQLLSEKDNVLQEHQKMSD-------DLVLANKEIERLKKDEQLARAEIKVL--QLANADLK 291
            :|||..|.::|..:.|..::.:       |...|.||:.:..||.:..|.|..|.  :...|.::
Zfish   478 QELNSSLVDRDRAICERNELLEKYCHEVKDKAEAQKELSQACKDIETVREERDVARKERTEAIIQ 542

  Fly   292 KRDLLKSRDSSWSKEFPSGKELEN-SKELEKLRKSLEKALSEVERSSQDAEEAKRVRDWAISQRE 355
            :..||:....:..|:..:..::|. :||::.|||..|....|::.:.|:||.||..||||..:|:
Zfish   543 RDQLLREYYQARQKQDSATLDMERANKEIDILRKQCEAMSQELKEAVQEAEVAKCRRDWAFQERD 607

  Fly   356 KIVQERDSVKTLCDKMRHERDKAISDSLMAIRDSEKIKKQKDEAQKKIDLLKEQMEQQERQNLDS 420
            |||.||:|::||||.:|.|||:|:||...|:|:.:.::||:::|.:::..|||:||.|    ||.
Zfish   608 KIVAERESIRTLCDNLRRERDRAVSDLADALRNLDDMRKQRNDAARELKELKEKMESQ----LDK 668

  Fly   421 NASGSR---RSFRPSSYEGEDL-LEVELSGYEHTSD------LGI-ILDDSNKRKLV--CG---- 468
            .|...:   .|...|:.:.:.| .|.|:..:|...|      :|. |.:..|...|.  ||
Zfish   669 EARFCQLMAHSSHDSAIDTDSLEWETEVVEFEKDRDDMDLKAMGFDIAEGVNDPYLPGDCGIFVS 733

  Fly   469 -VTSSSPACGKLKINDVICKVNNLDCQSLSKRMVLDEIRACAPRSLL-------LVSRTRHS--K 523
             |...|.|.|:|::||.:.|:|::|..:..::.|:        :::|       :|.|.|.|  .
Zfish   734 RVDKGSIADGRLRVNDWLLKINDVDLTNKDRKQVI--------KAVLNGGGLINMVVRRRKSLGG 790

  Fly   524 RHAYSVQLK-TRDRDCPHGLQLDMGVFIAKIEQNSLAFYEPELDVGDRVLSINNKSMDSVQSIEE 587
            |...||.:. ...:|.  |:.|:.|||:|.|...|.|..|..|.:|||:::||..::|: :|:.|
Zfish   791 RLVTSVHINLIGHKDA--GIALEGGVFVAGIAPGSPAAREGSLTIGDRLIAINGIALDN-KSLSE 852

  Fly   588 VMQLMNDPRSDGLNLFALKYVQDQLPPGMTTSSAQTDSIDSMQHVSSAGG-----GGGSGPSSAT 647
            ...|:...| |.|.|..:|:        ...|::..:..:|::....:.|     ...|..|...
Zfish   853 CEALLRGGR-DSLALSLMKF--------FPQSTSGQNIFESLREAEKSNGRIHLTDVHSRNSRNL 908

  Fly   648 KHPSRFAEFFF--------RKLKFSKPGTPEDNFEQEHDDAIAALDSVLSENSSE----KSKENL 700
            ||.|......:        ||   ::....|..|.:.....|:.|.......:||    :...:.
Zfish   909 KHNSSTQTDIYSCDTAGERRK---TRSDAEESLFSERKVFPISTLHPNTLRPASELGPVRYSASA 970

  Fly   701 FNRKKRTKKEK------------EASKSMGTWPR----TNISHENPT--GTMRGNEKKRALMSLF 747
            |.....|:.|.            |...|.||||:    ..::.::|.  ...|..::::::.
Zfish   971 FQEVCYTRSESVGPECVTLETTLEKKHSGGTWPKMVVGVAMTTDSPAQLSIYRSPKQRKSIF--- 1032

  Fly   748 TAGPINVDKDDELMGEVGVPEKQ----PAALIQDQLP-PPLPPQMSKPLAHIRGSNGGAIKTHPN 807
                     |.:.......|.|.    |..|..|..| ||.||..|.....          .|.:
Zfish  1033 ---------DADTFKRPDTPSKADYHGPQPLKADSAPTPPTPPTRSDSFKF----------KHKH 1078

  Fly   808 RNSNPVSSGVSALFPPGPP----NGMPNTSYPTHPRHSLY-----GVTAEEINQKPIQRAPLMGA 863
            :.|:...|.:||:....|.    ||            :||     .:::.:..::.|.|  :...
Zfish  1079 QGSSTSESTISAMSISEPKQEDRNG------------NLYFSEGKVLSSRKSCEEDIGR--MWAE 1129

  Fly   864 NARVKMPSQERYGTRPHSNHRLSLNITPSG----DFYQPKTSGQQAQQQVMNASST------SAG 918
            ...||.|       ||.|...|...:||..    .|......|...:|:.|..||.      |.|
Zfish  1130 EPEVKRP-------RPKSAPALRRRMTPQNIPLQSFQSYSNDGDSVEQREMLRSSPNRPHRHSVG 1187

  Fly   919 FGVGS-------GSMVGGTGPAAGEFPVRKQQVYDV----FHPPPLPKNSSGSNMFMPLHPTRGS 972
            |...|       .|...|..|.:....|.|..||.|    .|....|...|..|.       :.:
Zfish  1188 FVPTSYNGTLPPNSAHRGLAPCSAVTAVMKNPVYMVRSHRVHTNNCPTVVSQINQ-------QHT 1245

  Fly   973 HPPPVGQPPDVVSLKSQNSIESILSAKSPAISEYGMYAKRHVPQAVRHVPKYPSDSESIGSGVHG 1037
            ||.|..|....:.|..:.|.:...|::|...|                               ||
Zfish  1246 HPSPQHQGQLSLDLSQKRSTDYSESSRSSRAS-------------------------------HG 1279

  Fly  1038 GYGGFLQSNHMPGNRHTQLFPTFGPGGRGNRRSSPLTLPSPPPQQQLQQLPAATAPHDSVGIPTD 1102
                   :|.:|.:..                                           :|...:
Zfish  1280 -------TNSLPSSAR-------------------------------------------LGSSNN 1294

  Fly  1103 LDYHPHHHTQTNAMPHPHPHPHAPYLDYGHGLGIGPYMGVGGGVSGVGGAIYEGGTFPRKKDNQR 1167
            |.|.                                                          .:|
Zfish  1295 LQYR----------------------------------------------------------TER 1301

  Fly  1168 LRIPSNPSVASKSSSMVKNSSGSIDHHYVTS----TGPVSGGSMSASSSDRAPMSLMSSSIHNSY 1228
            ::|||.|..   ..|::.:..||:.|...:|    |.|:|            |::|.:||..:|.
Zfish  1302 IKIPSTPRY---PRSILGSDRGSLSHSECSSPSLITPPLS------------PLNLETSSFASSQ 1351

  Fly  1229 GANIAGGNGTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRV 1293
            .   .|...|...|.|           ||:|             :.:|..:.|  :|  .:.|.|
Zfish  1352 S---QGSISTLPRISV-----------SPVP-------------TEERRKDRP--YL--EEPRNV 1385

  Fly  1294 TIDKRDKSLGITIQCNNNGGGIFVSTVADKSTAMRAGLQVGDQLLEVCGINMRAATQEIAANVLR 1358
            .:.|..:.|||:|....| ||||||.|...|.|.:|||:.||||||..|||:|.||::.|..::.
Zfish  1386 MVHKGAEPLGISIVSGEN-GGIFVSKVTGGSIAHQAGLEYGDQLLEYNGINLRNATEQQARLIIG 1449

  Fly  1359 QCGDSFTMLVQYNPEKFPSIEYEGAHNLEPESPINHSGSPTPRNSPRPPARNSLFPLPMQPQAPS 1423
            |..|:.|::.||||..:..    |          |||     |:|.|           ::|.:..
Zfish  1450 QQCDTITIMAQYNPHMYQL----G----------NHS-----RSSSR-----------LEPVSTQ 1484

  Fly  1424 TRP---GSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSL 1485
            :.|   |:..|.:|.:|      |:|..|.:.:.:   |||..||.||:.::...:..|..|
Zfish  1485 STPQGSGTATPDNHSTI------DTLSEQDEGTLT---PSSKQTTPTTSPNSFIRMPSESSK--- 1537

  Fly  1486 PPPPASVPAETLRYVTLHMDKSKNLGIKLFGGNKVGIYVHDVAVGSPSDHA-GIRKGDQILEYNG 1549
                 .||  ..|.||:...:.: |||:|.|||..||:|..:...||:..| .:..||.||||..
Zfish  1538 -----KVP--EARLVTVRKTQVE-LGIQLCGGNLRGIFVERLEDDSPARGADAVVPGDMILEYGS 1594

  Fly  1550 VDLSGVTAEQAANEISKLTDTVTMLVQNKLHTLKQIKDEPGDSFYIRVGFDRTGELNEDDLRFVK 1614
            |::...|.|:|..|:.|..:|||:.||::|....|:|..|||.||||..:||..| .|.||.|.|
Zfish  1595 VNMKNKTVEEAYLEMLKPAETVTLRVQHRLDEFNQVKGTPGDGFYIRALYDRVAE-TELDLSFKK 1658

  Fly  1615 DEVLYVDNTVFNGTFGLWRAWKLDAMGHRKECGIIPSQMKVEEEL----RSGEVVDCDTGTARRG 1675
            |::||||:|:.||.||.|.||:||....:.:.|.|||:..:::|.    ...|:.| :||:::..
Zfish  1659 DDILYVDDTLPNGNFGTWMAWQLDENAQKIQRGQIPSKFMMDQEFYRRHSMTELKD-ETGSSKTL 1722

  Fly  1676 STSARRSFFRRK-KNQRSSSRDSTEIASFSNTQLSFFPDLGLLNDDGGALSYQRVELLDSPIRRP 1739
            |.:||||||||| |::||||:|..::.:.........|.|    ||..:|:||||:.:|....||
Zfish  1723 SAAARRSFFRRKHKHKRSSSKDGKDVVALDAISTDSIPFL----DDCVSLAYQRVQKIDCTSPRP 1783

  Fly  1740 VLIIGPLSECLMVRLTIDFSNLFKLCEVTAMDCSQEAMEEGLKENIFVDYRRRGNKFECTTVEAI 1804
            |||:|||.:.:...|..|....|..|.:..|..||:|:|.|:|:.:|:||:||...|:.|||.:|
Zfish  1784 VLILGPLVDPVKDMLVKDSPGKFSRCVLEVMKASQQAIERGVKDFLFIDYKRRSGHFDVTTVASI 1848

  Fly  1805 SNACKNDRRHCILDVSISAVERLQRLQIYPIVLLLRFKSAKQIRDIRD--FGTDKISAKAAKEMY 1867
            :.....| .||:||::..|:|||..:.|||||:.:|:|:||||::.:|  :..||:|.|.:||.:
Zfish  1849 NEITDKD-CHCLLDIAPHAIERLHSVHIYPIVIFIRYKNAKQIKEQKDPIYLRDKVSQKHSKEQF 1912

  Fly  1868 ERAMKLETDYKQYISAVIPGVSIKHMCTQIKDAVDKEQDKLLWVPVSS 1915
            |.|.|:|.||.::.:.::.|.:..::||||...||:||.|:||.|:.|
Zfish  1913 EIAQKIEQDYSKFFTGIVQGGTFPYICTQIVTIVDQEQSKVLWTPLGS 1960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211	48/209 (23%)
		CENP-F_leu_zip	229..360	CDD:287450	41/140 (29%)
		DUF1090	<326..408	CDD:284007	35/81 (43%)
		PDZ_signaling	439..516	CDD:238492	23/98 (23%)
		PDZ_signaling	533..592	CDD:238492	20/58 (34%)
		PDZ_signaling	1290..1369	CDD:238492	36/78 (46%)
		PDZ_signaling	1497..1576	CDD:238492	31/79 (39%)
		SH3_DLG5	1594..1657	CDD:212794	30/62 (48%)
		Guanylate_kin	1737..1904	CDD:279019	69/168 (41%)
		NK	<1773..1905	CDD:302627	56/133 (42%)
dlg5a	XP_005156738.1	CARD	9..88	CDD:260018
		Takusan	128..211	CDD:282652	18/99 (18%)
		Taxilin	295..627	CDD:286771	76/331 (23%)
		RILP-like	338..460	CDD:304877	19/121 (16%)
		SH3BP5	444..648	CDD:283045	65/203 (32%)
		PDZ_signaling	696..783	CDD:238492	21/94 (22%)
		PDZ_signaling	793..866	CDD:238492	26/76 (34%)
		PDZ	1381..1463	CDD:214570	38/82 (46%)
		dbPDZ_assoc	1461..1541	CDD:293216	30/128 (23%)
		PDZ	1541..1623	CDD:214570	33/82 (40%)
		SH3_DLG5	1639..1701	CDD:212794	30/62 (48%)
		Guanylate_kin	1780..1949	CDD:279019	69/169 (41%)
		NK	1794..1950	CDD:302627	61/156 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595055
Domainoid	1	1.000	119	1.000	Domainoid score	I5746
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	475	1.000	Inparanoid score	I1450
OMA	1	1.010	-	-		QHG47148
OrthoDB	1	1.010	-	-		D123652at2759
OrthoFinder	1	1.000	-	-		FOG0005387
OrthoInspector	1	1.000	-	-		otm25406
orthoMCL	1	0.900	-	-		OOG6_106741
Panther	1	1.100	-	-	LDO	PTHR46360
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5496
SonicParanoid	1	1.000	-	-		X4317
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800