Protein Alignment Dlg5 and Pals2

DIOPT Version :9

• Sequence 1: NP_609505.1
• Gene: Dlg5 / 34573
• FlyBaseID: FBgn0032363
• Length: 1916
• Species: Drosophila melanogaster
• Sequence 2: NP_001158205.1
• Gene: Pals2 / 56524
• MGIID: 1927340
• Length: 553
• Species: Mus musculus
• Alignment Length: 532
• Identity: 101/532 - (18%)
• Similarity: 207/532 - (38%)
• Gaps: 119/532 - (22%)

  Fly  1437 IKDQSFTDSLENQSDISSS-QDMPSSAATTTTTTASATSTVYDEEPKPSLPPPPASVPAETLRYV 1500
            :|:..|...||....::|. .|.|.|:                  |:.::|.....:|.:.:|.:
Mouse    84 LKEPHFQSLLEAHDIVASKCYDSPPSS------------------PEMNIPSLNNQLPVDAIRIL 130

  Fly  1501 TLHMDKSKNLGIKLFGGNKVGIYVHDVAVGSPSDHAG-IRKGDQILEYNGVDLSGVTAEQAANEI 1564
            .:|....:.||: .|......:.:..:..|...|..| :..||.|.|.||.:: |...::....:
Mouse   131 GIHKKAGEPLGV-TFRVENNDLVIARILHGGMIDRQGLLHVGDIIKEVNGHEV-GNNPKELQELL 193

  Fly  1565 SKLTDTVTMLVQNKLHTLKQIKD--EPGDSF-------------YIRVGFDRTG------ELNED 1608
            ..::.:||:.:      |...:|  .|..|:             :::..||...      ...|.
Mouse   194 KNISGSVTLKI------LPSYRDTITPQQSYVNMERHPAHVRQVFVKCHFDYNPFNDNLIPCKEA 252

  Fly  1609 DLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRKE---CGIIPSQMKVEEELRSGEVVDCDTG 1670
            .|:|.|.|:|.:.|   ......|:|      .|.||   .|:||||. :||:.::....|.|..
Mouse   253 GLKFSKGEILQIVN---REDPNWWQA------SHVKEGGSAGLIPSQF-LEEKRKAFVRRDWDNS 307

  Fly  1671 TARRGSTSARRSFFRRKKNQRSSSRDSTEIASFSNTQLSFFPDLGLLNDDGGALSYQRVELL--- 1732
            ....|:.|.:    ::||....::|:    |.|...::..:.::..:.      .:||..|:
Mouse   308 GPFCGTISNK----KKKKMMYLTTRN----AEFDRHEIQIYEEVAKMP------PFQRKTLVLIG 358

  Fly  1733 -----DSPIRRPVLIIGPLSECLMVRLTIDFSN-----------LFKLCEVTAMDCSQEAMEEGL 1781
                 ...::...:::.|    .....|:.|::           .:|.       .|:..||..:
Mouse   359 AQGVGRRSLKNRFIVLNP----ARFGTTVPFTSRKPREDEKDGQAYKF-------VSRSEMEADI 412

  Fly  1782 KENIFVDYRRRGNKFECTTVEAISNACKNDRRHCILDVSISAVERLQRLQIYPIVLLLRFKSAKQ 1846
            |...::::.........|.:::|....:..|. |||||:..|::.|:..:..|.|:   |.:|.:
Mouse   413 KAGKYLEHGEYEGNLYGTKIDSILEVVQTGRT-CILDVNPQALKVLRTSEFMPYVV---FIAAPE 473

  Fly  1847 IRDIR-------DFG--TDKISAKAAKEMYERAMKLETDYKQYISAVIPGVSIKHMCTQIKDAVD 1902
            :..:|       |.|  |..::....|:..:.:.:::..|..|...:|...::.....:::.|::
Mouse   474 LETLRAMHKAVVDAGITTKLLTDSDLKKTVDESARIQRAYNHYFDLIIVNDNLDKAFEKLQTAIE 538

  Fly  1903 KEQDKLLWVPVS 1914
            |.:.:..|||:|
Mouse   539 KLRMEPQWVPIS 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492
		PDZ_signaling	1497..1576	CDD:238492	17/79 (22%)
		SH3_DLG5	1594..1657	CDD:212794	19/71 (27%)
		Guanylate_kin	1737..1904	CDD:279019	31/186 (17%)
		NK	<1773..1905	CDD:302627	28/140 (20%)
Pals2	NP_001158205.1	L27	2..55	CDD:197794
		L27	57..108	CDD:397114	6/23 (26%)
		PDZ_signaling	132..205	CDD:238492	16/80 (20%)
		SH3_MPP6	232..292	CDD:212971	19/69 (28%)
		Guanylate_kin	350..540	CDD:395500	34/204 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810