DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlg5 and ush1c

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	XP_009296312.1	Gene:	ush1c / 564412	ZFINID:	ZDB-GENE-060312-41	Length:	586	Species:	Danio rerio

Alignment Length:	339	Identity:	72/339 - (21%)
Similarity:	135/339 - (39%)	Gaps:	93/339 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1290 LRRVTIDK-RDKSLGITIQCN-NNGGGIFVSTVADKSTAMRAGLQVGDQLLEVCGINMRAATQEI 1352
            |:.|.:|: ..:.||::::.. ..|.|:|:|.:.....|...||||||:::.:.|.::.:...|.
Zfish    85 LKEVRLDRTHPEGLGLSVRGGLEFGSGLFISQIVKDGQAGNVGLQVGDEIVRINGYSISSCIHEE 149

  Fly  1353 AANVLRQCGDSFTMLVQYNPEKFPSIEYEGAHNLEPESPINHSGSPTPRNSPRPPARNSLFPLPM 1417
            ..|:::             .:|..|::            :.|.|               :.|:
Zfish   150 VINLIK-------------TKKTVSLK------------VRHVG---------------MIPV-- 172

  Fly  1418 QPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPK 1482
                   :..|..||..|.: ||..::|.|..:.|                  :..:::...|.|
Zfish   173 -------KSSSDEPLKWQFV-DQFVSESGEKSNSI------------------AGLASIGGNEIK 211

  Fly  1483 PSLPPPPASVPAETLRYVTLHMDKSKNLGIKLFGG--NKVGIYVHDVAVGSPSDHAGIRKGDQIL 1545
            .              :.|.|.:..:|.:||.:..|  .|.||||.:|..||.|...|::.||||:
Zfish   212 E--------------KKVFLSLVGTKGMGISISSGPTKKPGIYVSNVKPGSLSAEVGLQVGDQIV 262

  Fly  1546 EYNGVDLSGVTAEQAANEISKLTDTVTMLVQNKLHTLKQIKDEPGDSFYIRVGFDRTGELNEDDL 1610
            |.|||:.:.::.::|. .:.|.:.::|:.|.....:...:.||.      |:..:...||:..:|
Zfish   263 EVNGVEFTNLSHQEAV-RVLKSSRSLTITVLTGAGSELFMTDEE------RLAVEARHELDRQEL 320

  Fly  1611 RFVKDEVLYVDNTV 1624
            ...|...|..:..|
Zfish   321 MHQKKVALETNKIV 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	19/80 (24%)
		PDZ_signaling	1497..1576	CDD:238492	27/80 (34%)
		SH3_DLG5	1594..1657	CDD:212794	7/31 (23%)
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
ush1c	XP_009296312.1	harmonin_N	2..80	CDD:259819
		PDZ_signaling	85..165	CDD:238492	21/104 (20%)
		PDZ_signaling	212..292	CDD:238492	27/94 (29%)
		RILP-like	317..>379	CDD:304877	4/18 (22%)
		PDZ_signaling	447..534	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900