DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and PARD3

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_062565.2	Gene:	PARD3 / 56288	HGNCID:	16051	Length:	1356	Species:	Homo sapiens

Alignment Length:	1173	Identity:	214/1173 - (18%)
Similarity:	352/1173 - (30%)	Gaps:	473/1173 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   911 NASSTSAGFGVGSGSMVG---GTGPAAGEFPVRKQQVYDVFHPPPLPKNSSGSNMFMPLHPTRGS 972
            :||||    |..|..:.|   ||...:...|.:.....:| .|..|..|       ||||..|.|
Human    92 SASST----GTQSPEIFGSELGTNNVSAFQPYQATSEIEV-TPSVLRAN-------MPLHVRRSS 144

  Fly   973 HPPPVGQPPDVVSLKSQNSIESILSAKSPAISEYGMYAKRHVPQAVRHVPKYPSDSESIGSGVHG 1037
            .|..:|        .|.:..:|..|::.|:                |..|...|.:
Human   145 DPALIG--------LSTSVSDSNFSSEEPS----------------RKNPTRWSTT--------- 176

  Fly  1038 GYGGFLQSN-----------------HMP---GNRHTQLFPTFGPGGRGNRRSSPLTLPSPPPQQ 1082
              .|||:.|                 .:|   .|...|.       .|.|.||| |:...|...:
Human   177 --AGFLKQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQF-------QRDNARSS-LSASHPMVGK 231

  Fly  1083 QLQQLPAATAPHDSVGIPTDLD-YHPHHHTQTNAMPHPH------------PHPHAPYLDYGHGL 1134
            .|::     ...|..|...|.. ..|..|..|.....|:            |:...|.     |:
Human   232 WLEK-----QEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPL-----GI 286

  Fly  1135 GIGPYMGVGGGVSGV-------GGAIYEGGTFPRKKD----------------------NQRLRI 1170
            .:.|:...||...|:       ||.......| |:.|                      .|.:|.
Human   287 HVVPFSARGGRTLGLLVKRLEKGGKAEHENLF-RENDCIVRINDGDLRNRRFEQAQHMFRQAMRT 350

  Fly  1171 P---------SNPSVASKSSSMVKN----SSGSIDHHYVTSTGPVSGGSMSASSSDR-------- 1214
            |         :|.....:.|...||    |..|.|..|:.:....|.|..:...:.|
Human   351 PIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQI 415

  Fly  1215 --------------APMSLMSSSIHNSYGANIAGGNGTGSSIGVGGGGGGGSGRGSPMPQVHVEV 1265
                          .|.|..:|:..|.:...::.|..| ..||               .:::::
Human   416 DSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNT-KKIG---------------KRLNIQ- 463

  Fly  1266 LSHGGGGSGKRNSNVPADFLCPGDLRRVTIDKRDKSLGITIQCNNNGGGIFVSTVADKSTAMRAG 1330
            |..|..|.|                  .:|..||.::|       ....|:|..:..:..|::.|
Human   464 LKKGTEGLG------------------FSITSRDVTIG-------GSAPIYVKNILPRGAAIQDG 503

  Fly  1331 -LQVGDQLLEVCGINMRAATQEIAANVLR--QCGDSFTMLVQYNPEKFPSIEYEGAHNLEPESPI 1392
             |:.||:|:||.|:::...:||...::||  :...:.::||....:.|...|.    |.||
Human   504 RLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPREL----NAEP---- 560

  Fly  1393 NHSGSPTPRNSPRPPARNSLFPLPMQPQAPS-----TRPGSRAPLSHQSIKDQSFTDSLENQSDI 1452
                              |...:|.:.:|..     |..|:|..|:.:
Human   561 ------------------SQMQIPKETKAEDEDIVLTPDGTREFLTFE----------------- 590

  Fly  1453 SSSQDMPSSAATTTTTTASATSTVYDEEPKPSLPPPPASVPAETLRYVTLHMDKSKNLGIKLFGG 1517
                                                           |.|:...|..||:.:.|.
Human   591 -----------------------------------------------VPLNDSGSAGLGVSVKGN 608

  Fly  1518 NK------VGIYVHDVAVGSPSDHAG-IRKGDQILEYNGVDLSGVTAEQAANEISKLTDT----- 1570
            ..      :||:|..:..|..:...| :|..||::..||..|.|.|.:.|...:.:...|
Human   609 RSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKR 673

  Fly  1571 --VTMLVQNKLHTLKQIK---DEPGDSFYIRVGFDRTGELNEDDLRFVKDEVLYVDNTVFNGTFG 1630
              :.::|..::....::|   ..||....|....|              |....:.:::::|..|
Human   674 GMIQLIVARRISKCNELKSPGSPPGPELPIETALD--------------DRERRISHSLYSGIEG 724

  Fly  1631 LWRAWKLDA-----MGHRKECG------------------------IIPSQMKVEEELRSGE--- 1663
            |..:...:|     ||   |.|                        ::|..:..:....|.:
Human   725 LDESPSRNAALSRIMG---ESGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVG 786

  Fly  1664 VVDCDTGTARRGSTS-----------------ARRSFFRRKKNQRSSSR--DSTEIASFSNTQLS 1709
            .|..|.||..:.:.|                 .|..|.|:..:::.:.:  |:::: .|..|:.|
Human   787 FVTADAGTWAKAAISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDASQL-DFVKTRKS 850

  Fly  1710 FFPDLGL-----LN------------DDGGALSYQRVELLDS--------------PIR--RPVL 1741
            ...|||:     ||            |.|.:|..::...|:|              |..  ||.:
Human   851 KSMDLGIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRI 915

  Fly  1742 IIG-PLSECLMVRLTIDFSNLFKLCEVTAMDCSQEAMEEGLKENIFVDYRRRGNKFECTTVEAIS 1805
            |.| ..:|..  |..||     |..:..|:|...|.||. |:|:. .:..|.|.:...|..:..|
Human   916 IRGRGCNESF--RAAID-----KSYDKPAVDDDDEGMET-LEEDT-EESSRSGRESVSTASDQPS 971

  Fly  1806 NAC------------KNDRRHCILDVSISAVERLQRLQIYPIVLLLRFKSAKQIRDIRDFGTDKI 1858
            ::.            |.||:                          :.|:.|:.:..||...||:
Human   972 HSLERQMNGNQEKGDKTDRK--------------------------KDKTGKEKKKDRDKEKDKM 1010

  Fly  1859 SAK 1861
            .||
Human  1011 KAK 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	20/81 (25%)
		PDZ_signaling	1497..1576	CDD:238492	21/92 (23%)
		SH3_DLG5	1594..1657	CDD:212794	12/91 (13%)
		Guanylate_kin	1737..1904	CDD:279019	31/140 (22%)
		NK	<1773..1905	CDD:302627	20/101 (20%)
PARD3	NP_062565.2	DUF3534	1..146	CDD:288873	20/65 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..100		5/11 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..262		27/147 (18%)
		PDZ_signaling	272..347	CDD:238492	12/80 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..448		4/39 (10%)
		PDZ_signaling	465..544	CDD:238492	22/103 (21%)
		PDZ_signaling	588..681	CDD:238492	21/156 (13%)
		Interaction with PRKCI and PRKCZ. /evidence=ECO:0000250\|UniProtKB:Q9Z340	712..936		42/234 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	865..886		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	932..1025		22/110 (20%)
		Interaction with FRMD4A. /evidence=ECO:0000250\|UniProtKB:Q99NH2	935..1356		22/107 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1129..1356
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810