DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlg5 and Tamalin

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_062391.3	Gene:	Tamalin / 56149	MGIID:	1860303	Length:	392	Species:	Mus musculus

Alignment Length:	403	Identity:	80/403 - (19%)
Similarity:	136/403 - (33%)	Gaps:	136/403 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1201 PVSGGSMSASSSDRAPMSLMSSSIHNSYGANIAGGNGTGSSIGVGGGGGGGSGRGSPMPQVHVEV 1265
            |:..|..:|::...||...:.:::.:.:.|.:.      .::.|.||         .:|:
Mouse    35 PLPSGPPAAAAPPGAPGEELYAALEDYHPAELY------RALAVSGG---------TLPR----- 79

  Fly  1266 LSHGGGGSGKRNSNVPADFLCPGDLRRV-TIDKRD-KSLGITIQCNNNGGGI------------F 1316
                ..|||.|..|....   |...|:| |::|.| ::.|..||..    |:            |
Mouse    80 ----RKGSGFRWKNFTQS---PEQQRKVLTLEKGDNQTFGFEIQTY----GLHHREEQRVEMVTF 133

  Fly  1317 VSTVADKSTAMRAGLQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLVQYNPEKFPSIEYE 1381
            |..|.:.|.|..|||..||.:..|.|:|:.........::::..|:...:...|.         .
Mouse   134 VCRVHESSPAQLAGLTPGDTIASVNGLNVEGIRHREIVDIIKASGNVLRLETLYG---------T 189

  Fly  1382 GAHNLEPESPINHSGSPTPRNSPRPPARNSLF-------PLPMQPQAPSTRPGSRAPLSH-QSIK 1438
            .....|.|:.:.:             .:.:|:       .|.:|.|.          |.| ..:|
Mouse   190 SIRKAELEARLQY-------------LKQTLYEKWGEYRSLMVQEQR----------LVHGLVVK 231

  Fly  1439 DQSFTDSLEN-QSDISSSQDMPSSAATTTTTTASATS-------------TVY------DEEPKP 1483
            |.|..|:||: :|.:..:..:|.|........|..::             .||      ..||:
Mouse   232 DPSIYDTLESVRSCLYGAGLLPGSLPFGPLLAAPGSARGGARRAKGDTDDAVYHTCFFGGAEPQ- 295

  Fly  1484 SLPPPP----------ASVPAETLRYVTLHMDKSKNLGIKLFGGNKVGIYVHDVAVGSPSD---- 1534
            :|||||          |..||..| :.......|::..::..|....|        |:|..
Mouse   296 ALPPPPPPARALGPSSAETPASVL-FPAPRSTLSRSASVRCAGPGGGG--------GAPGALWTE 351

  Fly  1535 -------HAGIRK 1540
                   .||:||
Mouse   352 AREQALCGAGLRK 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	23/92 (25%)
		PDZ_signaling	1497..1576	CDD:238492	10/55 (18%)
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
Tamalin	NP_062391.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50		3/14 (21%)
		PDZ_signaling	99..184	CDD:238492	22/88 (25%)
		Interaction with PSCD3. /evidence=ECO:0000269\|PubMed:10828067	180..257		18/108 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..315		7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900