DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlg5 and lrguk

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	XP_021330922.1	Gene:	lrguk / 559670	ZFINID:	ZDB-GENE-050419-232	Length:	739	Species:	Danio rerio

Alignment Length:	804	Identity:	145/804 - (18%)
Similarity:	255/804 - (31%)	Gaps:	294/804 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 SYIELEKDRNYYRERGD----------------ENQKLKVLLSQESKNVLSLTEELNQLLSEKD- 246
            :||.|:|....|.:..|                .||.......|..||:..:....||:.:.||
Zfish    57 NYIYLQKLELPYNKIKDLSCVSHMPYLITLDASHNQLTDFFGFQPPKNLKEVNFSHNQMTAMKDL 121

  Fly   247 -------NVLQEHQKMS-----------DDLVLANKEIERLKKDEQLARAEIKVLQLANADLKKR 293
                   .::.:|...|           ..|.||:..|.|::..:.|   .::.|.||...:.|.
Zfish   122 SAYSSLTKLILDHNSFSVIRGLEKCKRLSHLSLAHNNISRIRGLDHL---PLRELCLAGNMINKI 183

  Fly   294 DLLKSRDSSWSKEFPSGKELENSKELEKLRKSLEKALSEVERSSQ---DAEEAKRVRDWAISQRE 355
            :.|::..:....:. |...:::...|:.||     .|..|...|.   :.:||..:.|..:.:..
Zfish   184 ENLQTLHNLQVLDL-SCNRIQSLTGLQNLR-----FLGTVNLESNLITEIKEAAHLHDLILLREI 242

  Fly   356 KI----VQERDSVKTLCDKMRHERDKAISDSLMAIRDSEKIKKQKDEAQKKIDLLKEQMEQQERQ 416
            .:    ||:.|..:...              :..::....:.||...|::|:..:.:
Zfish   243 NLLKNPVQDHDDYRIAV--------------IFLLQHLILLDKQTVTAEEKVAAVNK-------- 285

  Fly   417 NLDSNASGSRRSFRPSSYEGEDLLEVELSGYEHTSDLGI------ILDDSNKRKLVCG----VTS 471
                        :.|.       ||| ::..:|.:.|..      ::.||....|...    |.:
Zfish   286 ------------YDPP-------LEV-VAARDHMTHLVYQLMQPQVIFDSTLPSLDAPYPMLVLT 330

  Fly   472 SSPACGKLKINDVIC---------------------KVNNLDCQSLSKRMVLDEIRACAPRSLLL 515
            ...||||.::...:|                     :.:.||...:::    :|..........:
Zfish   331 GPQACGKRELAHKLCQEFSDYFAYGACHTTRGPYFGEEDGLDYHFVTE----EEFHNMIQMGQFI 391

  Fly   516 VSRTRHSKRHAYSVQLKTRDRDCPHGL------QLDMGVFIAKIEQNSLAFYEPEL------DVG 568
              :|.....|.|.:..::.:|....||      :|: |||..|   ||  ::||..      .|.
Zfish   392 --QTMQYGGHWYGLSRESIERVAREGLACCVHMELE-GVFSLK---NS--YFEPRYVLLIPSVVD 448

  Fly   569 DRVLSI------NNKSMDSVQSIEEVMQLMN-------------DPRSD---GLNLFALKYV--- 608
            :.||.:      :|..|::..|..::...:|             |.|::   .|.....:|:
Zfish   449 NYVLFLKARGFYSNAQMETAVSRIDLYARINRERPGFFDSIIPCDDRAEAYRSLKQLVKEYLGLE 513

  Fly   609 --------------------QDQLPPGMTTSSAQTDSIDS------------------------- 628
                                ..:||....|.|  ||.:||
Zfish   514 EHSGGGDSSSITPDNTSTNTTGELPAASATES--TDLMDSYSRNYQKKIQANMTPQRTEMASNHR 576

  Fly   629 -MQHVSSAGGGGGSGPSSATKHPSRFAEFFFRKLKFSKPGTPEDNFEQEHDDAIAALDSV----- 687
             :|.:..|..|         |.|..:||.|.|    |.|..|.....|.|..|..:...|
Zfish   577 RLQQIREALSG---------KSPGAYAELFQR----SVPAAPSSLASQSHPPAGPSSSPVRPAGL 628

  Fly   688 ----LSENSSEKSKENLFNRKKRTKKEKEASKSMGTWPRTN---ISHENPTGTMRGNEKKRALMS 745
                |||:||                .:|:..|.|...|::   .|.|:|.   ||::.
Zfish   629 SAPNLSEDSS----------------SEESRASSGLSMRSSAGVFSAESPA---RGSDA------ 668

  Fly   746 LFTAGPINVDK-DDELMGEVGVPEKQPAALIQDQLPPPLPPQMSKPLAHIRGSNGGAIKTHPNRN 809
              .:|| |::. |..::|:    ::.....:....|.|...::|              .|||:..
Zfish   669 --GSGP-NIEPLDISMLGQ----DRDSLRGLTPDAPRPASDRVS--------------PTHPSSP 712

  Fly   810 SNPVSSGVSALFPPGPPNGMPNTS 833
            ..| .:.|..:.||.|.....|.|
Zfish   713 GRP-GANVKPVLPPIPSGRKTNDS 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211	33/168 (20%)
		CENP-F_leu_zip	229..360	CDD:287450	30/156 (19%)
		DUF1090	<326..408	CDD:284007	13/88 (15%)
		PDZ_signaling	439..516	CDD:238492	17/107 (16%)
		PDZ_signaling	533..592	CDD:238492	18/76 (24%)
		PDZ_signaling	1290..1369	CDD:238492
		PDZ_signaling	1497..1576	CDD:238492
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
lrguk	XP_021330922.1	LRR	<25..>247	CDD:227223	38/198 (19%)
		leucine-rich repeat	61..82	CDD:275380	4/20 (20%)
		leucine-rich repeat	83..104	CDD:275380	3/20 (15%)
		leucine-rich repeat	105..126	CDD:275380	4/20 (20%)
		leucine-rich repeat	127..148	CDD:275380	2/20 (10%)
		leucine-rich repeat	149..168	CDD:275380	5/18 (28%)
		leucine-rich repeat	170..191	CDD:275380	5/20 (25%)
		leucine-rich repeat	192..210	CDD:275380	2/18 (11%)
		leucine-rich repeat	211..238	CDD:275380	8/31 (26%)
		GMPK	326..449	CDD:238026	25/134 (19%)
		Herpes_ICP4_C	520..>739	CDD:332854	56/278 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900