Protein Alignment Dlg5 and PALS2

DIOPT Version :9

• Sequence 1: NP_609505.1
• Gene: Dlg5 / 34573
• FlyBaseID: FBgn0032363
• Length: 1916
• Species: Drosophila melanogaster
• Sequence 2: NP_001289966.1
• Gene: PALS2 / 51678
• HGNCID: 18167
• Length: 540
• Species: Homo sapiens
• Alignment Length: 492
• Identity: 95/492 - (19%)
• Similarity: 194/492 - (39%)
• Gaps: 106/492 - (21%)

  Fly  1474 STVYDEEPKPSLPPPPAS------------VPAETLRYVTLHMDKSKNLGIKLFGGNKVGIYVHD 1526
            |..||.        ||:|            :|.:.:|.:.:|....:.||: .|......:.:..
Human   101 SKCYDS--------PPSSPEMNNSSINNQLLPVDAIRILGIHKRAGEPLGV-TFRVENNDLVIAR 156

  Fly  1527 VAVGSPSDHAG-IRKGDQILEYNGVDLSGVTAEQAANEISKLTDTVTMLVQNKLHTLKQIKDE-P 1589
            :..|...|..| :..||.|.|.||.:: |...::....:..::.:||:.:      |...:|. .
Human   157 ILHGGMIDRQGLLHVGDIIKEVNGHEV-GNNPKELQELLKNISGSVTLKI------LPSYRDTIT 214

  Fly  1590 GDSFYIRVGFDRTG------ELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRKE--- 1645
            ....:::..||...      ...|..|:|.|.|:|.:.|   ......|:|      .|.||
Human   215 PQQVFVKCHFDYNPYNDNLIPCKEAGLKFSKGEILQIVN---REDPNWWQA------SHVKEGGS 270

  Fly  1646 CGIIPSQMKVEEELRSGEVVDCDTGTARRGSTSARRSFFRRKKNQRSSSRDSTEIASFSNTQLSF 1710
            .|:||||. :||:.::....|.|......|:.|::    ::||....::|:    |.|...::..
Human   271 AGLIPSQF-LEEKRKAFVRRDWDNSGPFCGTISSK----KKKKMMYLTTRN----AEFDRHEIQI 326

  Fly  1711 FPDLGLLNDDGGALSYQRVELL--------DSPIRRPVLIIGPLSECLMVRLTIDFSN------- 1760
            :.::..:.      .:||..|:        ...::...:::.|    .....|:.|::
Human   327 YEEVAKMP------PFQRKTLVLIGAQGVGRRSLKNRFIVLNP----TRFGTTVPFTSRKPREDE 381

  Fly  1761 ----LFKLCEVTAMDCSQEAMEEGLKENIFVDYRRRGNKFECTTVEAISNACKNDRRHCILDVSI 1821
                .:|.       .|:..||..:|...::::.........|.:::|....:..|. |||||:.
Human   382 KDGQAYKF-------VSRSEMEADIKAGKYLEHGEYEGNLYGTKIDSILEVVQTGRT-CILDVNP 438

  Fly  1822 SAVERLQRLQIYPIVLLLRFKSAKQIRDIR-------DFG--TDKISAKAAKEMYERAMKLETDY 1877
            .|::.|:..:..|.|:   |.:|.::..:|       |.|  |..::....|:..:.:.:::..|
Human   439 QALKVLRTSEFMPYVV---FIAAPELETLRAMHKAVVDAGITTKLLTDSDLKKTVDESARIQRAY 500

  Fly  1878 KQYISAVIPGVSIKHMCTQIKDAVDKEQDKLLWVPVS 1914
            ..|...:|...::.....:::.|::|.:.:..|||:|
Human   501 NHYFDLIIINDNLDKAFEKLQTAIEKLRMEPQWVPIS 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492
		PDZ_signaling	1497..1576	CDD:238492	17/79 (22%)
		SH3_DLG5	1594..1657	CDD:212794	19/71 (27%)
		Guanylate_kin	1737..1904	CDD:279019	31/186 (17%)
		NK	<1773..1905	CDD:302627	28/140 (20%)
PALS2	NP_001289966.1	L27	2..55	CDD:197794
		L27	57..108	CDD:397114	3/14 (21%)
		PDZ_signaling	133..206	CDD:238492	16/80 (20%)
		SH3_MPP6	219..279	CDD:212971	19/69 (28%)
		Guanylate_kin	337..527	CDD:395500	34/204 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810