DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and a

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_001014543.1	Gene:	a / 43852	FlyBaseID:	FBgn0000008	Length:	1329	Species:	Drosophila melanogaster

Alignment Length:	1548	Identity:	293/1548 - (18%)
Similarity:	457/1548 - (29%)	Gaps:	578/1548 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   391 KIKKQKD-----EAQKKIDLLKEQMEQQERQNLD-SNASGSRRSFRPSSYEGEDLLEVELSGYEH 449
            |.:|..|     .||::....::|..|.|..|:. |:.|.|.:|..|::.... |.:..:|....
  Fly     5 KTRKSTDTYSTLAAQQQQQQQQQQQHQAEGSNISHSSNSSSNKSHTPATCSNR-LNKSIVSSTSI 68

  Fly   450 TSDLGIILDDSNKRKLVCGVTSSSPACGKLKINDVIC--------KVNNLDCQSLSKRMVLDEIR 506
            :|.|..:.|.|....|.|...:|:.|.....:.....        .:.....|.|..:.....:|
  Fly    69 SSSLPDLHDKSPVMILSCTTLASNGATATAAVTATATGTAATSGGSLQQQQQQHLQHQQQQQPLR 133

  Fly   507 ACAPRSLLLVSRTRHSKRHAYSVQLKT---RDRDCPHGLQLDMGVFIAKIEQNSLAFYEPELDVG 568
            ...| :.||..|...|.....|:|..|   |.:..||              |....:......:|
  Fly   134 TATP-TCLLSGRQTPSAISVMSLQEATSLHRQQQQPH--------------QPPTIYVPVPTKLG 183

  Fly   569 DRVLSINNK-----SMDSVQSIEEVMQLMNDPRSDGLNLFALKYVQDQLPPGMTTSSAQTDSIDS 628
            :.|.:.|:.     |..|..||..:.|......:.     ..:||..:|      .:|.:..:
  Fly   184 NNVNTGNSSATLLLSYGSTSSIANLQQQQQQHAAQ-----YQQYVAQRL------HAASSSCL-- 235

  Fly   629 MQHVSSAGGGGGSGPSSATKHPSRFAEFFFRKLKFSKPGTPEDNFEQEH-DDAIAALDSVLSENS 692
            .:..|:|.||..|..||.:..|:.....:  ||..:.|....|:   || .:::.|.::  |.||
  Fly   236 YEKGSNASGGASSNKSSLSLTPNGHLPDY--KLVTAMPVVVLDD---EHKSNSLPATEA--SRNS 293

  Fly   693 SEKSKENLFNRKKRTKKEKEASKSMGTWPRTNISHENPTGTMRGNEKKRALMSLFTAGPINVDKD 757
            :..|..|            .:|.|.......:.||...:.::....:     ::||.|.....|.
  Fly   294 NSSSNMN------------GSSNSNSLDVSNSNSHSGSSTSLASTTR-----NVFTWGKRMSRKL 341

  Fly   758 DELMGEVGVPEKQPAALIQDQLPPPLPPQMSKPLAHIRGSNGGAIKTHPNRNSNPVSSGVSALFP 822
            |.|.     ....|||..:..  ..|......|..|..||.|         :|.|.|:..||
  Fly   342 DLLK-----RSDSPAAAHKSH--SDLRSLFHSPTHHKSGSGG---------SSGPSSAKASA--- 387

  Fly   823 PGPPNGMPNTSYPT---------------HPRHSLYGVTAEEINQKPIQRAPLMGANARVKMPSQ 872
             .|..|..|:|..|               ..||.     .::..|:.:|......:.:....|:.
  Fly   388 -SPTGGHQNSSGSTTSTLKKCKSGPIETIKQRHQ-----QQQQQQQSVQDVGTGQSQSAQSTPTH 446

  Fly   873 E----------------RYGTRPHSNHRLSLNITPSGDFYQPKTSGQQAQQQVMNASSTSAGFGV 921
            :                |.|:....||| |.|:..:.:..|..|   .|...:..:||||.   :
  Fly   447 QFQAAARPQKALKNFFHRIGSTGMLNHR-SHNLLKASEAAQQAT---PAATTLYRSSSTSQ---L 504

  Fly   922 GSGSMVGGTGPAAGEFPVRKQQVYDVFHPPPLPKNSSGSNMFMPLHPTRGSHPPPVGQPPDVVSL 986
            .|.|.|....|..|....|:|:...:                                 |.:.||
  Fly   505 SSSSYVKCDDPTEGLNLQREQREQRL---------------------------------PRIASL 536

  Fly   987 KSQN-----SIESILSAKSPAISEYGMYAKRHVPQAVRHVPKYPSDSESIG----SGVHGGYGGF 1042
            ||.:     .:.|.|:|.:.:.|..|                      |:|    |...||.|..
  Fly   537 KSSSCDDIAKVSSCLTASTSSGSAAG----------------------SLGSPPSSAAAGGGGTA 579

  Fly  1043 LQSNHMPGNRHTQLFP-TFGPGGRGNRRSSPLTLPSP----PPQQQLQQLPAATAPHDSVGIPTD 1102
            ....|.|..|..  || .|       .||....||..    .|....||:......|..
  Fly   580 NSGQHDPSRRGA--FPYAF-------LRSRLSVLPEENHGNVPGHLKQQIQRQREQHQQ------ 629

  Fly  1103 LDYHPHHHTQTNAMPHPHPHPHAPYLDYGHGLGIGPYMGVGGGVSGVGGAIYEGGTFPRKKDNQR 1167
               |.....|......|.|.                                      |:...|.
  Fly   630 ---HQRDLLQQEQTSSPLPQ--------------------------------------RRSPEQA 653

  Fly  1168 L--RIPSNPSVASK---------SSSMVKNSSGSIDHHYVT---STGPVSGGSMSASSSDRAPMS 1218
            :  .:..|.|:.||         ||.:..|.||     |.:   :||...|.::|.|..|..  |
  Fly   654 MLNNVSRNDSITSKDWEPLYQRLSSCLSSNESG-----YDSDGGATGARLGNNLSISGGDTE--S 711

  Fly  1219 LMSSSIHNSYGANIAGGNGTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPAD 1283
            :.|.::..:...:::...|.|..:|:..|.|..|.|.|.:....|.:     ||...
  Fly   712 IASGTLKRNSLISLSSSEGVGMGMGMSLGLGAPSTRNSSICSAPVSL-----GGYNY-------- 763

  Fly  1284 FLCPGDLRRVTIDKRDKSLGITIQCNNNGGGIFVS--TVADKST----------------AMRAG 1330
                 |....||.:|.:.:.:..:|..:..||.:|  ||...|.                |.:.|
  Fly   764 -----DYETETIRRRFRQVKLERKCQEDYIGIVLSPKTVMTNSNEQQYRYLIVELEPYGMAQKDG 823

  Fly  1331 -LQVGDQLLEVCGINMR-----AATQEIAANVLRQC------GDSFTMLVQYNPEKFPSIEYEG- 1382
             |::||:::.|.|.::|     |..|.:.::.:..|      .|..|.:..:    :..|..:|
  Fly   824 RLRLGDEIVNVNGKHLRGIQSFAEVQRLLSSFVDNCIDLVIAHDEVTTVTDF----YTKIRIDGM 884

  Fly  1383 ---------------------------------AHNLEPESP----------------------- 1391
                                             .||.|.|..
  Fly   885 STQRHRLSYVQRTQSTDSLSSMQSLQLQQERIQGHNTEQEQEAQGEDQCDARSMASVSTMPTPMP 949

  Fly  1392 -INHSGSPTPRNS-----P-----RPPARNS-------LFPLPM--------------------- 1417
             :.|..|.|||:|     |     |..||:|       |.|.|:
  Fly   950 LMQHRRSSTPRHSLDVGAPEHELLRRRARSSSGQRSLALTPTPLFASGSSSCSSSPNHRLLDNEN 1014

  Fly  1418 -----------------------------------------QPQAPSTRP-----GSRAPLSHQS 1436
                                                     :..|.|..|     |.|...:..|
  Fly  1015 DPANDTDSYTPVYANRAASVCVASSLADDEKWQLLARKRCSEGSALSATPNPQQFGQRTHYARNS 1079

  Fly  1437 IK-DQSFTDSLE-NQSDISSSQ-------------------DMPSSAATTTTTTASATSTVYDEE 1480
            |. ..|...||. ..|.:|||:                   :.|||.|||||...:......:::
  Fly  1080 INLANSHYRSLRFAHSRLSSSRLSLFMQAPPNSLTVGEGVANTPSSTATTTTDLTNQQQQQQNQQ 1144

  Fly  1481 -------------------PKP-------------------SLPPPPA-------SVP------- 1493
                               |.|                   ||.||.|       |:|
  Fly  1145 QTHQSLYIKHSPKSVSLFSPNPYVNASSSPASASTSAGAGSSLAPPAAALMHHRPSLPVAKLTIR 1209

  Fly  1494 ----AETLRY-----------VTLHMDKS---KNLGIKLFGG-----NKVGIYVHDV-AVGSPSD 1534
                ||.:|.           .|:...|.   |:||..:.||     ..:||:|..| ..|..:|
  Fly  1210 DEEMAEVIRASMSEGSGRCTPKTITFFKGPGLKSLGFSIVGGRDSPKGNMGIFVKTVFPSGQAAD 1274

  Fly  1535 HAGIRKGDQILEYNGVDLSGVTAEQAANEISKLTD--TVTMLVQNKLHTLKQI 1585
            ...::.||:|:|.||..:.|::..:.......:.:  .|..:::.||...|.:
  Fly  1275 DGTLQAGDEIVEINGNSVQGMSHAETIGLFKNVREGTIVLKILRRKLQKAKSM 1327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007	5/21 (24%)
		PDZ_signaling	439..516	CDD:238492	15/84 (18%)
		PDZ_signaling	533..592	CDD:238492	13/66 (20%)
		PDZ_signaling	1290..1369	CDD:238492	23/108 (21%)
		PDZ_signaling	1497..1576	CDD:238492	22/100 (22%)
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
a	NP_001014543.1	PDZ_signaling	775..865	CDD:238492	18/89 (20%)
a	NP_001014543.1	PDZ_signaling	1230..1317	CDD:238492	21/86 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900