Protein Alignment Dlg5 and MPP3

DIOPT Version :9

• Sequence 1: NP_609505.1
• Gene: Dlg5 / 34573
• FlyBaseID: FBgn0032363
• Length: 1916
• Species: Drosophila melanogaster
• Sequence 2: NP_001317162.1
• Gene: MPP3 / 4356
• HGNCID: 7221
• Length: 610
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 112/569 - (19%)
• Similarity: 216/569 - (37%)
• Gaps: 128/569 - (22%)

  Fly  1428 SRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPK----PSLPPP 1488
            |..|:.|.::  ....|.:|.....|...|........:|....|...|:|...:    |.|||.
Human    85 SPTPVLHSAV--ALAEDVMEELQAASVHSDERELLQLLSTPHLRAVLMVHDTVAQKNFDPVLPPL 147

  Fly  1489 PASV----PAETLRYVTLHMDKSKNLGIKLFGGNKVG-IYVHDVAVGSPSDHAG-IRKGDQILEY 1547
            |.::    ..|:::.|.|..:| :.||..:......| :.|..:..|..:|.:| :..||::.|.
Human   148 PDNIDEDFDEESVKIVRLVKNK-EPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREV 211

  Fly  1548 NGVDLSGVTAEQAANEISKLTDTVTMLVQNKLHTLKQIKDEPGDS-FYIRVGF------DRTGEL 1605
            ||:.:.....::.:..:::...::|:    |:....|.:|...:| .::|..|      ||....
Human   212 NGIAVLHKRPDEISQILAQSQGSITL----KIIPATQEEDRLKESKVFMRALFHYNPREDRAIPC 272

  Fly  1606 NEDDLRFVKDEVLYV---DNTVFNGTFGLWRAWKLD-----------------AMGHRKECGIIP 1650
            .|..|.|.:.:||.|   |:..:      |:|.::.                 .:.:|:..|.:|
Human   273 QEAGLPFQRRQVLEVVSQDDPTW------WQAKRVGDTNLRAGLIPSKGFQERRLSYRRAAGTLP 331

  Fly  1651 SQMKVE----EELRSGEVVDCDTGTARRGSTSARRSFFRRKKNQRSSSRDSTEIASFSNTQLSFF 1711
            |...:.    ::....|..||: |..:....:..|..||....:|.......:::|.:.:
Human   332 SPQSLRKPPYDQPCDKETCDCE-GYLKGHYVAGLRRSFRLGCRERLGGSQEGKMSSGAES----- 390

  Fly  1712 PDLGLLNDDGGALSYQRV-ELLDSPIRRP--VLIIGPLSECLMVRLTIDFSNLFKLCEVTAMD-- 1771
            |:|         |:|:.| .....|..||  |::||.|.           :.|.:|.:....:
Human   391 PEL---------LTYEEVARYQHQPGERPRLVVLIGSLG-----------ARLHELKQKVVAENP 435

  Fly  1772 --------------------------CSQEAMEEGLKENIFVDYRRRGNKFECTTVEAISNACKN 1810
                                      .|::|.|..|..|.|:::.........|::||| .|...
Human   436 QHFGVAVPHTTRPRKSHEKEGVEYHFVSKQAFEADLHHNKFLEHGEYKENLYGTSLEAI-QAVMA 499

  Fly  1811 DRRHCILDVSISAVERLQRLQIYPIVLLLRFKSAKQIRDIRDFGTDKISA----------KAAKE 1865
            ..:.|::||...|:::|:..:..|.::.::    ..|::.|.  |..:|.          :..:|
Human   500 KNKVCLVDVEPEALKQLRTSEFKPYIIFVK----PAIQEKRK--TPPMSPACEDTAAPFDEQQQE 558

  Fly  1866 MYERAMKLETDYKQYISAVIPGVSIKHMCTQIKDAVDKEQDKLLWVPVS 1914
            |...|..::..|...:.||:....::...:|:|..::|......|||||
Human   559 MAASAAFIDRHYGHLVDAVLVKEDLQGAYSQLKVVLEKLSKDTHWVPVS 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492
		PDZ_signaling	1497..1576	CDD:238492	16/80 (20%)
		SH3_DLG5	1594..1657	CDD:212794	17/92 (18%)
		Guanylate_kin	1737..1904	CDD:279019	37/206 (18%)
		NK	<1773..1905	CDD:302627	30/141 (21%)
MPP3	NP_001317162.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810