DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dlg5 and MPP2

DIOPT Version :9

Sequence 1:NP_609505.1 Gene:Dlg5 / 34573 FlyBaseID:FBgn0032363 Length:1916 Species:Drosophila melanogaster
Sequence 2:XP_011523129.2 Gene:MPP2 / 4355 HGNCID:7220 Length:630 Species:Homo sapiens


Alignment Length:656 Identity:124/656 - (18%)
Similarity:242/656 - (36%) Gaps:162/656 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  1338 LEVCGINMRAATQEIAAN-------------------------VLRQCGDSFTML--VQYN---P 1372
            :.|...|...|.|::..|                         ::|.......:|  :|.|   |
Human    55 MPVAATNSETAMQQVLDNLGSLPSATGAAELDLIFLRGIMESPIVRSLAKVIMVLWFMQQNVFVP 119

  Fly  1373 EKFPSIEYEGAHNLEPESPINHSGSPTPRNSPRPPARNSLFPLPMQPQAPSTRPGSRAPLSHQSI 1437
            .|: .::|.|||....|:.:.     ..|::.....:..|..|....:..||    .|.|:| .:
Human   120 MKY-MLKYFGAHERLEETKLE-----AVRDNNLELVQEILRDLAQLAEQSST----AAELAH-IL 173

  Fly  1438 KDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSLPPPPAS--VPAETLRYV 1500
            ::..|...||....:                   |:.|.....|.|.|.|..::  ||.:.:|.|
Human   174 QEPHFQSLLETHDSV-------------------ASKTYETPPPSPGLDPTFSNQPVPPDAVRMV 219

  Fly  1501 TLHMDKSKNLGI--KLFGGNKV-GIYVHDVAVGSPSDHAGIRKGDQILEYNGVDLSGVTAEQAAN 1562
            .:.....::||:  ::.||..| ...:|.   |..:....:..||.|.|.||..:.  :..:|..
Human   220 GIRKTAGEHLGVTFRVEGGELVIARILHG---GMVAQQGLLHVGDIIKEVNGQPVG--SDPRALQ 279

  Fly  1563 EISK-LTDTVTMLV---QNKLHTLKQIKDEPGDSFYIRVGFD----RTGEL--NEDDLRFVKDEV 1617
            |:.: .:.:|.:.:   ..:.|..:|:        :::..||    |...:  .|..|||...::
Human   280 ELLRNASGSVILKILPSYQEPHLPRQV--------FVKCHFDYDPARDSLIPCKEAGLRFNAGDL 336

  Fly  1618 LYVDNTVFNGTFGLWRAWKLDAMGHRKECGIIPSQMKVEEELRSGEVVDCD----TGTARRGSTS 1678
            |.:.|   ......|:|..::.    ...|:||||: :||:.::....|.:    :||. .||.|
Human   337 LQIVN---QDDANWWQACHVEG----GSAGLIPSQL-LEEKRKAFVKRDLELTPNSGTL-CGSLS 392

  Fly  1679 ARRSFFRRKKNQRSSSRDSTEIASFSNTQLSFFPDLGLLNDDGGALSYQRVELLDSPIRRPVLII 1743
            .       ||.:|.... :|:.|.|...:|               |.|:.|..: .|.||..|::
Human   393 G-------KKKKRMMYL-TTKNAEFDRHEL---------------LIYEEVARM-PPFRRKTLVL 433

  Fly  1744 ----GPLSECLMVRL----------TIDFSNLFKLCEVTAMDCSQEA----------MEEGLKEN 1784
                |.....|..:|          |:.:::.      ...|..:|.          ||..::..
Human   434 IGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSR------RPKDSEREGQGYSFVSRGEMEADVRAG 492

  Fly  1785 IFVDYRRRGNKFECTTVEAISNACKNDRRHCILDVSISAVERLQRLQIYPIVLLLRFKSAKQIRD 1849
            .::::.........|.:::|....... :.|:|||:..||:.|:..:..|.|:.:.....:.:|.
Human   493 RYLEHGEYEGNLYGTRIDSIRGVVAAG-KVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDFETLRA 556

  Fly  1850 IR------DFGTDKISAKAAKEMYERAMKLETDYKQYISAVIPGVSIKHMCTQIKDAVDKEQDKL 1908
            :.      ...|.:::....:...|.:.:::..|..|....:...:::....:::.|::|.:.:.
Human   557 MNRAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNLERTFRELQTAMEKLRTEP 621

  Fly  1909 LWVPVS 1914
            .|||||
Human   622 QWVPVS 627

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dlg5NP_609505.1 AAA_23 <165..333 CDD:290211
CENP-F_leu_zip 229..360 CDD:287450
DUF1090 <326..408 CDD:284007
PDZ_signaling 439..516 CDD:238492
PDZ_signaling 533..592 CDD:238492
PDZ_signaling 1290..1369 CDD:238492 7/57 (12%)
PDZ_signaling 1497..1576 CDD:238492 18/85 (21%)
SH3_DLG5 1594..1657 CDD:212794 16/68 (24%)
Guanylate_kin 1737..1904 CDD:279019 28/196 (14%)
NK <1773..1905 CDD:302627 21/147 (14%)
MPP2XP_011523129.2 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.