Protein Alignment Dlg5 and pyd

DIOPT Version :10

• Sequence 1: NP_609505.1
• Gene: Dlg5 / 34573
• FlyBaseID: FBgn0032363
• Length: 1916
• Species: Drosophila melanogaster
• Sequence 2: NP_001246998.1
• Gene: pyd / 41062
• FlyBaseID: FBgn0262614
• Length: 2395
• Species: Drosophila melanogaster
• Alignment Length: 1268
• Identity: 275/1268 - (21%)
• Similarity: 451/1268 - (35%)
• Gaps: 396/1268 - (31%)

  Fly   784 PPQMS--------KPLAHIR-GSNGGAIKTHPNRNSNPVSSGVSALFPPGPPNGMPNTS------ 833
            ||:.:        :|.|::| |..|||        ..|.||||..:     .:.:..||
  Fly    14 PPKSNVYNPLVRYRPTAYVRNGIIGGA--------EGPGSSGVYQI-----ADRVYTTSKMFLRD 65

  Fly   834 ---YPTHPRHSLYGVTAEEINQKPIQRAPLMGANARVKMPSQERYGTRPHSNHRLSLNITP---- 891
               ||..|..::......|:::.|.|    .||..                   |.|...|
  Fly    66 GYMYPRQPGQTMDPRFPLELHEFPQQ----FGATG-------------------LQLVSAPKVHI 107

  Fly   892 SGDFYQPKTSGQQAQQQVMNASSTSAGFGVGSGSMVGGTGPAAGEFPVRKQQVYDVFHPPPLPKN 956
            :|::...:...||.|||..:..       |.....:|....||........|||
  Fly   108 AGEYLASEQQQQQQQQQQQHQQ-------VQEQQQLGRRKAAAAAEINLANQVY----------- 154

  Fly   957 SSGSNMFMPLHPTRGSHPPPVGQPPDVVSLKSQNSIESILSAKSPAISEYGMYAKRHVPQAVRHV 1021
                  ::....||              |....||:
  Fly   155 ------WLGKQKTR--------------SRSRSNSV----------------------------- 170

  Fly  1022 PKYPSDSESIGSGVHGGYGGFLQSNHMPGNRH-------TQLFPTFGPGGRGNRRSSPLTLPSPP 1079
                 .:.||.|.:.||.||..:.....|:|.       ..|....|....|:..|:.|...|..
  Fly   171 -----GNRSITSCMGGGGGGGEKERERGGDRDRPYIRNVDDLLQALGKRDGGDNNSNLLETASTH 230

  Fly  1080 PQQQLQQLPAATAPHDSVGIPTDLDYHPHHHTQTNAMPHPHPHPHAPYLDYGHGLGI-----GPY 1139
            ...|.::.        ..|..|..:||....|:...              ||.|:.:     .|:
  Fly   231 SSSQRRRF--------KKGDRTTWEYHTVAVTRVPG--------------YGFGIAVSGGRDNPH 273

  Fly  1140 MGVGGGVSGVGGAIYEGGTFPRKKDNQRL---------------------------------RIP 1171
            ...|.....|...:..|....|.:.|.|:                                 |:|
  Fly   274 FANGDPSIAVSDVLKGGPAEDRLQVNDRIISVNGVSLENVEYATAVQVLRDSGNTVQLVVKRRVP 338

  Fly  1172 SNPSVASKSSSMVKNSSGSIDHHYVTSTGPVSGGSMSASSSDRAPMSLMSSSIHNSYGANIAGGN 1236
            .||.          |::|::.|.:..|...|  |.|:..|...||..:.|.|..||..:::....
  Fly   339 LNPI----------NAAGAVQHQHSHSLSSV--GLMANGSGGVAPTPITSLSQPNSLNSSLVQNA 391

  Fly  1237 GTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRVTIDKRDKS 1301
            .:|..|.|                    .|:.||                          |:| .
  Fly   392 SSGQPIKV--------------------TLTKGG--------------------------KKD-D 409

  Fly  1302 LGITIQCNNNGGGIFVSTVADKS----TAMRAGLQVGDQLLEV----CGINMRAATQEIAANVLR 1358
            .|:.:.|.     :||..::.|:    .|....||.||.:..:    ||..|   :.:.|..::.
  Fly   410 YGVVLGCR-----LFVKEISSKAREQLNANGYSLQEGDIITRIHNTNCGDTM---SLKEAKKIID 466

  Fly  1359 QCGDSFTMLV-----------QYNPEKFPSIEYEGAHNLEPESPINHSGSPTPRNSPRPP----- 1407
            .|.:...::|           |.|...  |..::.:.|:........||..:..|:...|
  Fly   467 GCKERLNLVVLRDITNQTAVSQLNLNN--SASHQASGNIYATHQPQVSGCSSSNNNLEDPYLPGG 529

  Fly  1408 ARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQS------DISSSQ-DMPSSAATT 1465
            |..|...|.:|   |.||..:...::...:.|:....:...:|      .:|..| |.|
  Fly   530 ASYSSQNLYVQ---PPTRTSNGPNINGNGLNDEKSNLTPRGRSRGPIMDGVSLQQLDRP------ 585

  Fly  1466 TTTTASATSTVYDEEPKPSLPPPPAS--------------------VPAETLRYVTLHMDKSKNL 1510
             .|.....|...||.|:|  |||..|                    ..||. |:::  ..|..::
  Fly   586 -VTPTRGRSAAIDEPPRP--PPPRGSSGGAAQEDFYSSRRQLYEERQSAEP-RFIS--FQKEGSV 644

  Fly  1511 GIKLFGGNKVGIYVHDVAVGSPSDHAGIRKGDQILEYNGVDLSGVTAEQAANEISKLTDTVTMLV 1575
            ||:|.|||:.||:|..|..|||:...|:..||:||:.|.:|::|||.|:|...:..|.|.:.::|
  Fly   645 GIRLTGGNEAGIFVTAVQPGSPASLQGLMPGDKILKVNDMDMNGVTREEAVLFLLSLQDRIDLIV 709

  Fly  1576 QN-KLHTLKQIKDEPGDSFYIRVGFDRTGELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDA 1639
            |. |....:.:.::.||||:|:..| .....::.::.|...:|..|.:|:.||..|.|:..|: .
  Fly   710 QYCKEEYDEVVTNQRGDSFHIKTHF-HCDNPSKGEMAFKAGDVFRVIDTLHNGVVGSWQVLKI-G 772

  Fly  1640 MGHRK-ECGIIPSQMKVEEELRSGEVVDCDTGTARRGST-------SARRSFFRRKKN----QRS 1692
            .||:: :.|:||::.:.||           ..||:..:|       .:|.:||||:::    .:|
  Fly   773 RGHQEMQRGVIPNKSRAEE-----------LATAQFNATKKEMNANESRGNFFRRRRSTHRRSKS 826

  Fly  1693 SSRDSTEIASFSNTQLSFFPDLGLLNDDGGALSYQRVELLDSPIRRPVLIIGPLSECLMVRLTID 1757
            .||::.:...||:: :|.||            :|:||.|......|||::.||:|:....||..|
  Fly   827 LSRENWDDVVFSDS-ISKFP------------AYERVVLRHPGFVRPVVLFGPVSDLARERLAKD 878

  Fly  1758 FSNLFKLCEVTAMDCSQEAMEEGLKENIFVDYRRRGNKFECTTVEAISNACKNDR-RHCILDVSI 1821
            |.:.|   .....|..:.|...|                :|..|...:.....|| :|.:||::.
  Fly   879 FPDKF---STPLQDDDKSAATSG----------------KCRIVRLSNIRDVMDRGKHALLDITP 924

  Fly  1822 SAVERLQRLQIYPIVLLLRFKSAKQIRDIRDFGTDKISAKAAKEMYERAMKLETDYKQYISAVIP 1886
            :||:||...|.||:|:.|:..|...|:.:| .|..|.:.|::|::.|:..|||..:....|..|.
  Fly   925 NAVDRLNYAQFYPVVIFLKTDSKHVIKQLR-HGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIA 988

  Fly  1887 GVSIKHMCTQIKDAVDKEQDKLLWV----PVSS 1915
            ....:....:::|::|.:|...:|:    ||.|
  Fly   989 LSDEESWYRKLRDSIDLQQSGAVWMSESKPVES 1021

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	COG1340	176..>416	CDD:440951
		PDZ_canonical	441..516	CDD:467153
		PDZ_canonical	540..609	CDD:483948
		PDZ3_DLG5-like	1288..1370	CDD:467248	18/100 (18%)
		PDZ_canonical	1498..1576	CDD:483948	29/77 (38%)
		SH3_DLG5	1594..1657	CDD:212794	16/63 (25%)
		NK	<1773..1905	CDD:450170	33/132 (25%)
pyd	NP_001246998.1	PDZ1_ZO1-like	249..335	CDD:467209	12/99 (12%)
		PDZ2_ZO1-like_ds	397..479	CDD:467210	23/136 (17%)
		PDZ3_ZO1-like_domain	632..711	CDD:467211	31/81 (38%)
		SH3_ZO	729..790	CDD:212793	16/62 (26%)
		GuKc	831..1007	CDD:214504	54/208 (26%)
		ZU5	2264..2365	CDD:459941