DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and pyd

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_001246998.1	Gene:	pyd / 41062	FlyBaseID:	FBgn0262614	Length:	2395	Species:	Drosophila melanogaster

Alignment Length:	1268	Identity:	275/1268 - (21%)
Similarity:	451/1268 - (35%)	Gaps:	396/1268 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   784 PPQMS--------KPLAHIR-GSNGGAIKTHPNRNSNPVSSGVSALFPPGPPNGMPNTS------ 833
            ||:.:        :|.|::| |..|||        ..|.||||..:     .:.:..||
  Fly    14 PPKSNVYNPLVRYRPTAYVRNGIIGGA--------EGPGSSGVYQI-----ADRVYTTSKMFLRD 65

  Fly   834 ---YPTHPRHSLYGVTAEEINQKPIQRAPLMGANARVKMPSQERYGTRPHSNHRLSLNITP---- 891
               ||..|..::......|:::.|.|    .||..                   |.|...|
  Fly    66 GYMYPRQPGQTMDPRFPLELHEFPQQ----FGATG-------------------LQLVSAPKVHI 107

  Fly   892 SGDFYQPKTSGQQAQQQVMNASSTSAGFGVGSGSMVGGTGPAAGEFPVRKQQVYDVFHPPPLPKN 956
            :|::...:...||.|||..:..       |.....:|....||........|||
  Fly   108 AGEYLASEQQQQQQQQQQQHQQ-------VQEQQQLGRRKAAAAAEINLANQVY----------- 154

  Fly   957 SSGSNMFMPLHPTRGSHPPPVGQPPDVVSLKSQNSIESILSAKSPAISEYGMYAKRHVPQAVRHV 1021
                  ::....||              |....||:
  Fly   155 ------WLGKQKTR--------------SRSRSNSV----------------------------- 170

  Fly  1022 PKYPSDSESIGSGVHGGYGGFLQSNHMPGNRH-------TQLFPTFGPGGRGNRRSSPLTLPSPP 1079
                 .:.||.|.:.||.||..:.....|:|.       ..|....|....|:..|:.|...|..
  Fly   171 -----GNRSITSCMGGGGGGGEKERERGGDRDRPYIRNVDDLLQALGKRDGGDNNSNLLETASTH 230

  Fly  1080 PQQQLQQLPAATAPHDSVGIPTDLDYHPHHHTQTNAMPHPHPHPHAPYLDYGHGLGI-----GPY 1139
            ...|.::.        ..|..|..:||....|:...              ||.|:.:     .|:
  Fly   231 SSSQRRRF--------KKGDRTTWEYHTVAVTRVPG--------------YGFGIAVSGGRDNPH 273

  Fly  1140 MGVGGGVSGVGGAIYEGGTFPRKKDNQRL---------------------------------RIP 1171
            ...|.....|...:..|....|.:.|.|:                                 |:|
  Fly   274 FANGDPSIAVSDVLKGGPAEDRLQVNDRIISVNGVSLENVEYATAVQVLRDSGNTVQLVVKRRVP 338

  Fly  1172 SNPSVASKSSSMVKNSSGSIDHHYVTSTGPVSGGSMSASSSDRAPMSLMSSSIHNSYGANIAGGN 1236
            .||.          |::|::.|.:..|...|  |.|:..|...||..:.|.|..||..:::....
  Fly   339 LNPI----------NAAGAVQHQHSHSLSSV--GLMANGSGGVAPTPITSLSQPNSLNSSLVQNA 391

  Fly  1237 GTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRVTIDKRDKS 1301
            .:|..|.|                    .|:.||                          |:| .
  Fly   392 SSGQPIKV--------------------TLTKGG--------------------------KKD-D 409

  Fly  1302 LGITIQCNNNGGGIFVSTVADKS----TAMRAGLQVGDQLLEV----CGINMRAATQEIAANVLR 1358
            .|:.:.|.     :||..::.|:    .|....||.||.:..:    ||..|   :.:.|..::.
  Fly   410 YGVVLGCR-----LFVKEISSKAREQLNANGYSLQEGDIITRIHNTNCGDTM---SLKEAKKIID 466

  Fly  1359 QCGDSFTMLV-----------QYNPEKFPSIEYEGAHNLEPESPINHSGSPTPRNSPRPP----- 1407
            .|.:...::|           |.|...  |..::.:.|:........||..:..|:...|
  Fly   467 GCKERLNLVVLRDITNQTAVSQLNLNN--SASHQASGNIYATHQPQVSGCSSSNNNLEDPYLPGG 529

  Fly  1408 ARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQS------DISSSQ-DMPSSAATT 1465
            |..|...|.:|   |.||..:...::...:.|:....:...:|      .:|..| |.|
  Fly   530 ASYSSQNLYVQ---PPTRTSNGPNINGNGLNDEKSNLTPRGRSRGPIMDGVSLQQLDRP------ 585

  Fly  1466 TTTTASATSTVYDEEPKPSLPPPPAS--------------------VPAETLRYVTLHMDKSKNL 1510
             .|.....|...||.|:|  |||..|                    ..||. |:::  ..|..::
  Fly   586 -VTPTRGRSAAIDEPPRP--PPPRGSSGGAAQEDFYSSRRQLYEERQSAEP-RFIS--FQKEGSV 644

  Fly  1511 GIKLFGGNKVGIYVHDVAVGSPSDHAGIRKGDQILEYNGVDLSGVTAEQAANEISKLTDTVTMLV 1575
            ||:|.|||:.||:|..|..|||:...|:..||:||:.|.:|::|||.|:|...:..|.|.:.::|
  Fly   645 GIRLTGGNEAGIFVTAVQPGSPASLQGLMPGDKILKVNDMDMNGVTREEAVLFLLSLQDRIDLIV 709

  Fly  1576 QN-KLHTLKQIKDEPGDSFYIRVGFDRTGELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDA 1639
            |. |....:.:.::.||||:|:..| .....::.::.|...:|..|.:|:.||..|.|:..|: .
  Fly   710 QYCKEEYDEVVTNQRGDSFHIKTHF-HCDNPSKGEMAFKAGDVFRVIDTLHNGVVGSWQVLKI-G 772

  Fly  1640 MGHRK-ECGIIPSQMKVEEELRSGEVVDCDTGTARRGST-------SARRSFFRRKKN----QRS 1692
            .||:: :.|:||::.:.||           ..||:..:|       .:|.:||||:::    .:|
  Fly   773 RGHQEMQRGVIPNKSRAEE-----------LATAQFNATKKEMNANESRGNFFRRRRSTHRRSKS 826

  Fly  1693 SSRDSTEIASFSNTQLSFFPDLGLLNDDGGALSYQRVELLDSPIRRPVLIIGPLSECLMVRLTID 1757
            .||::.:...||:: :|.||            :|:||.|......|||::.||:|:....||..|
  Fly   827 LSRENWDDVVFSDS-ISKFP------------AYERVVLRHPGFVRPVVLFGPVSDLARERLAKD 878

  Fly  1758 FSNLFKLCEVTAMDCSQEAMEEGLKENIFVDYRRRGNKFECTTVEAISNACKNDR-RHCILDVSI 1821
            |.:.|   .....|..:.|...|                :|..|...:.....|| :|.:||::.
  Fly   879 FPDKF---STPLQDDDKSAATSG----------------KCRIVRLSNIRDVMDRGKHALLDITP 924

  Fly  1822 SAVERLQRLQIYPIVLLLRFKSAKQIRDIRDFGTDKISAKAAKEMYERAMKLETDYKQYISAVIP 1886
            :||:||...|.||:|:.|:..|...|:.:| .|..|.:.|::|::.|:..|||..:....|..|.
  Fly   925 NAVDRLNYAQFYPVVIFLKTDSKHVIKQLR-HGLPKAAHKSSKKLLEQCQKLERVWSHIFSTQIA 988

  Fly  1887 GVSIKHMCTQIKDAVDKEQDKLLWV----PVSS 1915
            ....:....:::|::|.:|...:|:    ||.|
  Fly   989 LSDEESWYRKLRDSIDLQQSGAVWMSESKPVES 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	18/97 (19%)
		PDZ_signaling	1497..1576	CDD:238492	29/78 (37%)
		SH3_DLG5	1594..1657	CDD:212794	16/63 (25%)
		Guanylate_kin	1737..1904	CDD:279019	45/167 (27%)
		NK	<1773..1905	CDD:302627	33/132 (25%)
pyd	NP_001246998.1	PDZ_signaling	249..334	CDD:238492	12/98 (12%)
		PDZ_signaling	396..477	CDD:238492	22/135 (16%)
		PDZ_signaling	633..710	CDD:238492	29/79 (37%)
		SH3_ZO	729..790	CDD:212793	16/62 (26%)
		GuKc	831..1007	CDD:214504	54/208 (26%)
		ZU5	2263..2351	CDD:279170
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460594
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840