DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and dlg4b

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_999893.1	Gene:	dlg4b / 405796	ZFINID:	ZDB-GENE-040628-3	Length:	801	Species:	Danio rerio

Alignment Length:	921	Identity:	210/921 - (22%)
Similarity:	333/921 - (36%)	Gaps:	288/921 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1071 SPLTLPSPPPQQQLQQLPAATAPHDSVGIPTDLDYHPHHHTQTNAMPHPHPHPHAPYLDYGHGLG 1135
            ||..|.:....:.|....:..||.|.:..     |.|..|. :.|.|...|..||||  |.....
Zfish    85 SPAHLSTGKSAEMLHLGDSGHAPIDGIHA-----YTPQMHV-SPAKPVLLPSGHAPY--YATSTL 141

  Fly  1136 IGPYMGVGG-----------GVSGVGGAIYEGGTFPRKKDNQRLRIPSNPSV----------ASK 1179
            :.   |:.|           |.||:|.:| .|||     ||.  .|..:||:          |::
Zfish   142 MN---GMDGDVEYEEITLERGNSGLGFSI-AGGT-----DNP--HIGDDPSIFITKIIPGGAAAQ 195

  Fly  1180 SSSMVKNSS----GSIDHHYVTSTGPVSGGSMSASSSDRAPMSLMSSSIHNSYGANIA------G 1234
            ...:..|.|    ..:|...||.:..|.      :..:..|:..:....|......|.      |
Zfish   196 DGRLRVNDSILFVNDVDVREVTHSFAVE------ALKEAGPIVRLYVLRHKPSAEKITELKLIKG 254

  Fly  1235 GNGTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRVTIDKRD 1299
            ..|.|.||                           .||.|  |.:||.|
Zfish   255 PKGLGFSI---------------------------AGGVG--NQHVPGD---------------- 274

  Fly  1300 KSLGITIQCNNNGGGIFVSTVADKSTAMRAG-LQVGDQLLEVCGINMRAATQEIAANVLRQCGDS 1363
                         ..|:|:.:.:...|.:.| ||:||::|.|..:.:.....|.|...|:..||.
Zfish   275 -------------NSIYVTKIIEGGAAHKDGRLQIGDKILAVNNMYLEEVMHEDAVAALKNTGDV 326

  Fly  1364 FTMLVQYNPEKFPSIEYEGAHNLEPESPINHSGSPTPRNSPRPPARNSLFPLPMQPQAPSTRPGS 1428
            ..:.|   .:......::.|:|           .|...:|..|....|.:|..:.|.:|.
Zfish   327 VFLRV---AKTLHQHHHQDAYN-----------PPDITSSYSPHMDMSDYPQALSPSSPR----- 372

  Fly  1429 RAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSLPPPPASVP 1493
                .:..|....|.|     .|||                         .||
Zfish   373 ----RYSPIPKGLFLD-----DDIS-------------------------REP------------ 391

  Fly  1494 AETLRYVTLHMDKSKNLGIKLFGG-NKVGIYVHDVAVGSPSDHAG-IRKGDQILEYNGVDLSGVT 1556
                |.|.:|.. |..||..:.|| :..||::..:..|..:|.:| :|||||||..|||||...|
Zfish   392 ----RRVVIHRG-STGLGFNIVGGEDGEGIFISFILAGGAADLSGELRKGDQILSVNGVDLRHAT 451

  Fly  1557 AEQAANEISKLTDTVTMLVQ----------NKLHTLK-QIKDEP-----------GDSFYIRVGF 1599
            .||||..:.....|||::.|          .|:|.|: |:.:..           ..||:||..|
Zfish   452 HEQAAAALKNAGQTVTIITQYRPEEYSRFEAKIHDLREQLMNSSLVSAAASLRSGKRSFFIRALF 516

  Fly  1600 D----RTGELNEDDLRFVKDEVLYV----DNTVFNGTFGLWRAWKLDAMGHRKECGIIPSQMKVE 1656
            |    ..|......:.|...:||.|    |..       .|:|.||...|..:|.|.|||:.:||
Zfish   517 DYDKTADGGFLSQAVSFRFGDVLQVFDCSDEE-------WWQAGKLAPHGELEETGYIPSKRRVE 574

  Fly  1657 EELRSGEVVDCDTGTARRGSTSARRSFFRRKKNQRSSSRDSTEIASFSNTQLSFFPDLGLLNDDG 1721
                                         ||:..|..:|....::..|:.
Zfish   575 -----------------------------RKEWSRLKTRGREPVSGRSDY--------------- 595

  Fly  1722 GALSYQRVELLDSPIRRPVLIIGPLSECLMVRLTIDFSNLFKLC-----------EVTAMD---- 1771
             .:||:.|...:....|||:|:||..:.:...|..:|.:.|..|           |:...|
Zfish   596 -IVSYETVTQSEVHYARPVIILGPSKDRVNDDLLSEFPDKFGSCVPHTTRPKREYEMDGRDYHFV 659

  Fly  1772 CSQEAMEEGLKENIFVDYRRRGNKFECTTVEAISNACKNDRRHCILDVSISAVERLQRLQIYPIV 1836
            .|:|.||:.::.:.|::..:..:....|:|:::....:...:|||||||.:||.|||..|:|||.
Zfish   660 SSREQMEKDIQSHRFIEAGQYNSHLYGTSVQSVRQVAEQQGKHCILDVSANAVRRLQAAQLYPIA 724

  Fly  1837 LLLRFKSAKQIRDIRDFGTDKISAKAAKEMYERAMKLETDYKQYISAVIPGVSIKHMCTQIKDAV 1901
            :.:|..|.:.:.:|    :.:::.:.|:...:||:|||.|:.:..||::.|.|.:.:...:|..:
Zfish   725 IFIRPSSLQNVLNI----SKRLTEEQARRALDRAVKLEQDFIECFSAIVEGESFEEIYHHVKSVI 785

  Fly  1902 DKEQDKLLWVP 1912
            :::....:|:|
Zfish   786 EEQSGPYIWIP 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	15/79 (19%)
		PDZ_signaling	1497..1576	CDD:238492	33/80 (41%)
		SH3_DLG5	1594..1657	CDD:212794	21/70 (30%)
		Guanylate_kin	1737..1904	CDD:279019	50/181 (28%)
		NK	<1773..1905	CDD:302627	38/131 (29%)
dlg4b	NP_999893.1	L27_1	4..58	CDD:286187
		MAGUK_N_PEST	71..152	CDD:287565	20/77 (26%)
		PDZ	153..237	CDD:278991	21/97 (22%)
		PDZ	245..331	CDD:214570	28/143 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..373		9/53 (17%)
		PDZ_assoc	342..392	CDD:287558	17/115 (15%)
		PDZ_signaling	391..471	CDD:238492	34/96 (35%)
		SH3	509..574	CDD:302595	22/71 (31%)
		Guanylate_kin	609..788	CDD:279019	50/182 (27%)
		GuKc	617..788	CDD:214504	46/174 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910