DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlg5 and Syn1

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_001262192.1	Gene:	Syn1 / 40424	FlyBaseID:	FBgn0037130	Length:	627	Species:	Drosophila melanogaster

Alignment Length:	397	Identity:	93/397 - (23%)
Similarity:	158/397 - (39%)	Gaps:	93/397 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1221 SSSIHNSYGANIAGGNGTGSSIGVGGGGGGGSGRGSPMPQ------VHVEVL------------- 1266
            |::::.:.|:|.:||.|.|:    ||||.||.|:...:|.      ::::..
  Fly    73 STTLNGTLGSNHSGGGGGGA----GGGGTGGGGQNGTLPNSASLQGMNIQDTELDGSASNDNGDR 133

  Fly  1267 -------SHGGGGSGKRNSNVPADFLCPGDLRRVTIDKRDKS-LGITIQCNNNGGG--------- 1314
                   ::.|.|.|....:|| |.:. ...|.|.|.|.|.: |||:|:     ||
  Fly   134 DPCLNNNNNAGDGGGMDMCDVP-DHVA-NQKRHVRIIKSDNNGLGISIK-----GGRENRMPILI 191

  Fly  1315 --IFVSTVADKSTAMRAGLQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLVQYNPEKFP- 1376
              ||....||::    .||.|||.:|.|.|..:|.||.:.|...|::.|....:.|::..|..|
  Fly   192 SKIFRGMAADQA----KGLYVGDAILTVNGEELRDATHDEAVRALKRSGRVVDLEVKFLREVTPY 252

  Fly  1377 ----SIEYEGAHNLE-----PESPINHSGSPTPRNSPRPPARNSLFPLPMQPQAPSTRPGSRAPL 1432
                ||..|....|:     |..|...:..|.|:.:||...|.    :|:|             |
  Fly   253 FRKASIISEVGWELQRAFLCPLGPGVPTSPPAPKTTPRADTRY----IPLQ-------------L 300

  Fly  1433 SHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSLPPPPASVPAETL 1497
            :|.: ::..:.|. ||:.....|.|...|.......:|.|  .|:......::........||..
  Fly   301 THLA-RNLKYIDP-ENRCFELHSPDGVHSCILRAADSAEA--LVWFNALHSAMGTSTQRALAEAN 361

  Fly  1498 RYVTLHMDKSKNLG---IKLFGGNKVGIYVHDVAVGSPSDHAGIRKGDQILEYNGVDLSGVTAEQ 1559
            |.:|..:.:.|::|   .::.||...|      :.|..:...|....:.::....|..||.::.:
  Fly   362 RALTNLIGELKHIGWLSKRMSGGGSSG------SAGGGAASGGSGTSNSVVAGELVSPSGRSSSE 420

  Fly  1560 AANEISK 1566
            :::|..|
  Fly   421 SSDESDK 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	29/90 (32%)
		PDZ_signaling	1497..1576	CDD:238492	14/73 (19%)
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
Syn1	NP_001262192.1	PH-like	30..>61	CDD:302622
		PDZ_signaling	163..244	CDD:238492	29/89 (33%)
		PHsplit_syntrophin	<293..351	CDD:269960	14/78 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900