DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dlg5 and bbg

DIOPT Version :9

Sequence 1:NP_609505.1 Gene:Dlg5 / 34573 FlyBaseID:FBgn0032363 Length:1916 Species:Drosophila melanogaster
Sequence 2:NP_001246755.1 Gene:bbg / 39583 FlyBaseID:FBgn0087007 Length:2637 Species:Drosophila melanogaster


Alignment Length:2133 Identity:411/2133 - (19%)
Similarity:705/2133 - (33%) Gaps:660/2133 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 TSTSSQEEE-------SSEYVGYD-NTLRPPS--NSSGSTTA-------ANMSNNNGPSKGVSSG 59
            ||:||.||:       :.||:..| ..|.||.  |..|.:.|       :||....|..:...|.
  Fly   709 TSSSSGEEDEDDLDASNREYICEDGEKLGPPELINGPGPSEAYFNMFWHSNMLPTIGEVEEEFSS 773

  Fly    60 VGVSGISGGNGANYDILQAQYKSAL--LELNT----------LRHQHANTKRRCDELATELTLYQ 112
            :....::.||     :::::....|  :|:|.          :....|:..|.  :...|:|..|
  Fly   774 LEPQSLTNGN-----LVKSEESKKLPKMEVNAGGLAQLTDDKIADHDASATRA--DTRDEVTTNQ 831

  Fly   113 EHYVADRNKFTDMVEESARFKRLLLETQNQQSQQAQNGNSQVPPVG-SGNPYYFGKTQGCDGSCS 176
            ...::..:..:...:::....|:.....:..|..:...::.:|.|. ...||     :..|...|
  Fly   832 TQEISSSSSSSVKSQKTTTTTRVTTTKTSSSSSSSSCSSTVIPDVAFKLQPY-----EERDDILS 891

  Fly   177 EKLAELKKERNMVA--------------------VEREKYKKSYIELEK--DRNYYRERGDE--- 216
            |.:..:.:||.:::                    |.....|.|....:|  ..:...:.|||   
  Fly   892 EPITTIHEERRVLSEQKTLSESRTRDALTGEEQLVTSANSKSSSARFKKISSNDNLLDLGDEQDM 956

  Fly   217 -NQKLKVLLSQES----------------KNVLSLTEELNQL-------------LSEKDNVLQE 251
             .|.|...::|||                :..|:|:|...||             .|||::.|:.
  Fly   957 QEQPLTATITQESSLRERLECPQDNQSIDRGTLTLSERGKQLSEKEGLTTYTECETSEKESYLEG 1021

  Fly   252 HQ----------------------KMSDDLVLANK-EIERLKKDEQLARAEIKVLQLANADLKKR 293
            .|                      ::|:.|.:.|. |.:..||.||  ..||       |..|..
  Fly  1022 QQVLNGKGGFVSQDENSDQPTYEREVSETLTIVNDGEKQVTKKLEQ--NKEI-------AGKKGA 1077

  Fly   294 DLLKSRDSSWSKEFPSGKELEN----SKELEKLRKSLEKA-------LSEVERSSQD-----AEE 342
            .|||..|.....|..:.|.:|:    .||.|||.| ||.|       ||..|::.::     :||
  Fly  1078 KLLKKTDEERRLEQEAQKLIESYQKVKKEAEKLYK-LELADDDQGFDLSAFEQAEEEDKPEVSEE 1141

  Fly   343 AKRVRDWAISQREKI-VQERDSVKT--------LCDKMRHERDKAISDSLMAIRDSEKIKKQ--- 395
            .|.|:|   ||..|: :|..:.|||        ..:.:..|..:.:..|...|:...|:..|   
  Fly  1142 IKEVKD---SQPVKVDIQIEEEVKTPNQVIGEVKVEDVNKEIKETVQVSQQEIKKEVKVSHQETK 1203

  Fly   396 -------KDEAQKKIDLLKEQME------QQERQNLDS---------NASGSRRSFRPSSYEGED 438
                   |||: .::.::||:::      :::.|.:::         ....|.:....:|:: :.
  Fly  1204 ETFKSEEKDES-NELKIVKEEVKVTHQDLREQIQEIEAVKVVHKEVKVIKESAKVTTTTSHK-QA 1266

  Fly   439 LLEVELSGYEHTSDLGIILDDSNKRKLVCGVTSSSPACGKLKINDVICKVNNLDCQSLSKRMVLD 503
            ..||.:|..:|.:|                  |:.||....|:..:...:.:.....|.|.::..
  Fly  1267 TKEVIISKEDHKND------------------SALPAVSTTKVEIISPPLEDDLGYVLHKHIIFP 1313

  Fly   504 EIRA-CAPRSL---------------LLVSRTR--------HSKRHAYS------------VQLK 532
            :.:. .||..|               :.|:.|:        .|||...|            ..|:
  Fly  1314 QEKVKTAPTPLPKPKPKPPVPTNKPKMPVNLTKPKSAPPPVPSKRSELSGSGGKPTPTQRRGSLE 1378

  Fly   533 TRDRDCPHGLQLDMGVFIAKIEQNSLAFYEPELD---VGDRVLSINNKSMDSVQSIEEVMQLMND 594
            |.....|      :...|..:||..    |||..   :....:.:.|.:.:|.|:..|...::..
  Fly  1379 TAQPPKP------LERIIVGVEQRD----EPEKPQPIINLASVDLPNVAPNSKQATVETTPVVEM 1433

  Fly   595 PRSDGLNLFALKYVQDQLP-----------------PGMTTSS-----------AQTDSIDSMQH 631
            |..:      |::...|||                 .|.::||           :.|.|:||:|.
  Fly  1434 PPDE------LQFESHQLPDDGEKEKDLHQESNDLLSGSSSSSVTTPITTPILVSATSSMDSVQS 1492

  Fly   632 VSSAGGGGGSGPSSATKHPSRFAEFFFRKLKFSKPGTPEDNFEQEHDDAIAALDSVLSENSSEKS 696
            |.....|                          .|.......:.:..|.:||.|..:...:....
  Fly  1493 VIEVVNG--------------------------MPIISNQQTDDDDIDEVAAYDDGMHLEAEGTK 1531

  Fly   697 KENLFNRKKRTKKEKEASKSMGTWPR----------TNISHENPTGTMRGNEKKRALMSLFT--- 748
            .............::|....:||...          .|.|...|..|:..:..|:......|   
  Fly  1532 DVRPVQEVTTLTLDREHESDLGTLSNHHSNISSISGINASSNIPAATLISSSIKKTSTEAATTKP 1596

  Fly   749 AGPINVDKDDELMGEVGVPEKQPAA-------------LIQD-----------QLPP---PLPPQ 786
            |.|....|.:.|....|.......|             |:||           :|||   ..||.
  Fly  1597 AAPQIPGKMELLSSNTGTTTTTTTATHHLHQATTTKQLLVQDYLSYASPPTYSRLPPDGHEFPPN 1661

  Fly   787 MSKPLAHIRGSNGGAIKTHPNRNSNPVSSGV------SALFPP----GPPNGMPNTSYPTHPRHS 841
            .|:||         .:.:||.:.:..:|..:      .:..||    |||..:|...|    |..
  Fly  1662 FSEPL---------IMHSHPLKVTTELSYEIQKGGKDESSAPPLPKTGPPATVPRKVY----RQD 1713

  Fly   842 LYGVTAEEINQKP-------IQRAPLMGANARVKMPSQERYGTRPHSNHR---------LSLNIT 890
            |.      ||.:|       .||: |.|...|  .||..|...:...:.|         ..|:..
  Fly  1714 LV------INVEPAPSLTRDYQRS-LSGGTPR--KPSDWRKDEKSEKSVRDKIAMFSSNNELDAI 1769

  Fly   891 PSGDFYQPKTSG------QQAQQQVMNASSTSAGFGVGSGSM-VGGTGPAAGEFPVRKQ------ 942
            |......|.:|.      .::.:.::::.|:|:...:.:.:| |........::.:.||      
  Fly  1770 PPAPATAPISSSFTRKPLNRSSENLLDSCSSSSAPSLKTRAMSVENLNDVQRQYQLAKQLPQLHV 1834

  Fly   943 --QVYDVFHPPPLPKNSSGSNMFMPLHPTRGSHPPPV-------GQPPDVVSLKSQNSIESILSA 998
              .:|.:....|.|..:|     :|.....||:...|       |:..|..:.|:  :|.:||..
  Fly  1835 ADSMYSLNTATPTPSYAS-----LPRRSHGGSYSSGVERRISFSGEGGDAANRKA--AITNILEQ 1892

  Fly   999 KSPAISEYGMYAKRHVPQAVRHVPKYPSDSESI--GSGVHGGYGGFLQSNHMPGNRHTQLFPTFG 1061
            :..::|:.........||.:..:...|.....:  .||......|..:|:....||:.||    |
  Fly  1893 RRRSLSKLRGLVIPERPQLLEPILDLPEIKSQVKAASGEDSTDSGLGESHRSTVNRNCQL----G 1953

  Fly  1062 PGGRGNRRSSPL-TLPSPPPQQQLQQLPAATAPHDSVGIPTDLDYHPHHHTQTNAMPHPHPHPHA 1125
            .||..|...|.| |....|.:|||.| |.|..|..|:   |.|        |..:|..|   |..
  Fly  1954 AGGAANNYRSILNTNQRRPLEQQLSQ-PPAKPPRTSL---TPL--------QPRSMMIP---PPP 2003

  Fly  1126 PYLD--------YGHGLGIGPYMGVGGGVSGVGGAIYEGGTFPRKKDNQR-LRIPSNPSVASKSS 1181
            |.||        :.|...:                    .|.|.|....| |...:|.|:||.::
  Fly  2004 PPLDQESDTDSVFSHTARV--------------------ATPPEKFALTRTLSSETNTSIASSNT 2048

  Fly  1182 SMVKNSSGSIDHHYVTSTGPVSGGSMSASSSDRAPMSLMSSSIHNSYGANIAGGNGTGSSIGVGG 1246
            |.:             ::|..:|...|.||....|...::..:..|...|       |.::.:  
  Fly  2049 STL-------------TSGSSAGSQASCSSLGSTPAVDLTRRVLKSQVIN-------GEAVAL-- 2091

  Fly  1247 GGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRVTIDKRDKSLGITIQCNNN 1311
                 |.|.|    :............|:...|...|    |:...:. ::|.|.          
  Fly  2092 -----SSRKS----ILASAKCRSAKSRGQEEDNDSTD----GEACSLA-NRRMKP---------- 2132

  Fly  1312 GGGIFVSTVADKSTAMRAGLQ-VGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLVQYNPEKF 1375
                 :|:...:...::.|.| |.|:|:.|      ||..|:.::.......|.|      |.|.
  Fly  2133 -----ISSYKLQQQQIQLGKQLVVDKLINV------AAYVELTSDTDDSSRRSDT------PAKI 2180

  Fly  1376 PSIEYEGAHNLEPESPINHSGSPTPRNSPRPPARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKD- 1439
                  .|..::.|...:..|.|   |.........:.|:.:....||.:   |.||..|:..: 
  Fly  2181 ------SAMFIDEERKASFKGDP---NQQAKVKVEQVKPMVLPMLLPSAK---REPLKQQTTAEL 2233

  Fly  1440 -QSFTDS------LENQSDI--------------------SSSQDMPSSAATTTTTTASATS--- 1474
             :.|..|      .:|.|.:                    |||..:.|:....:||..:||.   
  Fly  2234 REKFERSAAAQAQTQNHSPVIHKVTQKPHHERFSSLDSLASSSSGVSSTTQNVSTTQETATEFGS 2298

  Fly  1475 -----------TVYD-----EEPKPSLPPPPASVPAETLRYVTLHMDKSKNLGIKLFGGNKV--- 1520
                       |..|     ||..|.|..|.|.:      .|....:...::||.|.||:..   
  Fly  2299 FSSLGSNQSLITAQDVQQIVEEADPPLKTPEAFI------IVLQRENPESSIGITLAGGSDYEAK 2357

  Fly  1521 GIYVHDVAVGSPSDHAG-IRKGDQILEYNGVDLSGVTAEQAANEISKLTDTVTMLV--------- 1575
            .|.:|.:...:|:...| ::|||:||..||:.:.|:|..::.:.:......|.::|         
  Fly  2358 EITIHKILSNTPAAKDGRLKKGDRILAVNGMSMRGLTHRESISVLKTPRPEVVLVVTRSESLVVK 2422

  Fly  1576 -----QNKLHTLKQIKDEPGDSFYIRV-GFDRTGELNEDDLRFVKDEV--LYVDNTVFNGTFGLW 1632
                 ::.|.:|..:.::|.:..|.|. .:.:.....:.||..|.:|.  ..|..|...|:....
  Fly  2423 ALTKKRSSLGSLSSLNEKPTELDYERKRNYHKASRSLDLDLDLVSNEAGESPVATTPSTGSVSPP 2487

  Fly  1633 RAWKLDAMGHRKECGIIPSQMKVEEELRSGEVVDCDTGTARRGSTSARRSFFRRKKNQRSSSRDS 1697
            :...|    |.::.....:.::...:|..|:.....|......:..||.:.....:.|...:..|
  Fly  2488 QPASL----HDEDAEATIAGIRARRQLSRGDAAKLSTSELLERAAEARNAIAAEIRAQAEDAAAS 2548

  Fly  1698 ------TEIASFSNTQLSFFPDLGL-LNDDGGALSYQRVELLDSPI-RRPVLI 1742
                  .||...|         .|| .:.:||         .|||: .||:::
  Fly  2549 GGGARCVEIVKDS---------CGLGFSIEGG---------FDSPLGNRPLIV 2583

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dlg5NP_609505.1 AAA_23 <165..333 CDD:290211 57/256 (22%)
CENP-F_leu_zip 229..360 CDD:287450 49/183 (27%)
DUF1090 <326..408 CDD:284007 26/112 (23%)
PDZ_signaling 439..516 CDD:238492 14/92 (15%)
PDZ_signaling 533..592 CDD:238492 12/61 (20%)
PDZ_signaling 1290..1369 CDD:238492 14/79 (18%)
PDZ_signaling 1497..1576 CDD:238492 21/96 (22%)
SH3_DLG5 1594..1657 CDD:212794 11/65 (17%)
Guanylate_kin 1737..1904 CDD:279019 2/6 (33%)
NK <1773..1905 CDD:302627
bbgNP_001246755.1 PDZ_signaling 90..177 CDD:238492
ATP-synt_B <1084..>1109 CDD:304375 6/24 (25%)
PDZ_signaling 2331..2413 CDD:238492 20/87 (23%)
PDZ_signaling 2553..2634 CDD:238492 12/49 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.