DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and ssp6

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_001286952.1	Gene:	ssp6 / 38694	FlyBaseID:	FBgn0035676	Length:	866	Species:	Drosophila melanogaster

Alignment Length:	823	Identity:	145/823 - (17%)
Similarity:	234/823 - (28%)	Gaps:	319/823 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   378 AISDSLMAIRDSEKIKKQKDEAQKKIDLLKEQMEQQERQNLDSNASGSRRSFRPSSYEGEDLLE- 441
            ::...:.|....|:....:..:|.:...|..|..||....::...|..|..|..|....::.:|
  Fly    36 SVGSLIAAACQQEQPHPHQHYSQSQQQHLYHQSHQQASHYVNGTGSLGRLKFHKSLDASDEEIEY 100

  Fly   442 VELSGYEHTSDLGIILDDSNKRKLVCGVTSSSPACGKLKINDVICKVNNLDCQSLSKRMVLDEIR 506
            .:||...|     |:....::|.|     :|:|                            ||.|
  Fly   101 AQLSRSTH-----ILGRHKSERYL-----ASNP----------------------------DEDR 127

  Fly   507 ACAPRSLLLVSRTRHS---KRHAYSVQLKTRDRDCPHGLQLDMGVFIAKIEQNSLAFYEPELDVG 568
            .   |..::|.:..:|   ...:|.:..| ||.      :|:|..::..:|....| |...:..|
  Fly   128 R---RRTIIVEKKNNSYGFTLQSYGIHYK-RDE------ELEMITYVDYVEYGGPA-YRAGMREG 181

  Fly   569 DRVLSINNKSMDSVQS---IEEVMQLMNDPRSDGLNLFA---------LKYVQDQLPPGMTTSSA 621
            |.:||||.|.|:....   :|.:.|.  |.|...:.||.         ::|:|
  Fly   182 DVILSINGKDMEKADHKTIVEFIKQC--DTRMRMVVLFEDCVRKVDLHMRYIQ------------ 232

  Fly   622 QTDSIDSMQHVSSAGGGGGSGPSSATKHPSRFAEFFFRKLKFSKPGTPEDNFEQEHDDAIAALDS 686
                                                                          |.|
  Fly   233 --------------------------------------------------------------LQS 235

  Fly   687 VLSENSSEKSKENLFNRKKRTKKEKEASKSMGTWPRTNISHENPTGTMRGNEKKRALMSLFTAGP 751
            :|.:..:|..:.:|        :|:|..:  |.|.    :|..|.       :|:|        .
  Fly   236 MLQQKMNELERVHL--------RERELLE--GKWK----THSLPA-------RKKA--------N 271

  Fly   752 INVDKDD-------ELMGEVGVPEKQPAALIQDQLPPPLPPQMSKPLAHIRGSNGGAIKTHPNRN 809
            .|....|       |:.||.|.  .:||...:|.                           ||..
  Fly   272 ANTSPSDGEGVSPTEVAGEAGF--YRPALSTEDV---------------------------PNIA 307

  Fly   810 SNPVSSGVSALFPPGPPNGM-------PNTSYPTHPRHSLYGVTAEEINQKPIQRAPLMGANARV 867
            :.....|...:.|| |...|       |...|...|.|   |.:.|.::...:||:
  Fly   308 ARQHGVGGPGIIPP-PAQFMLTYHYLDPTYRYVLRPTH---GSSEEFVDGLGLQRS--------- 359

  Fly   868 KMPSQERYGTRPHSNHRLSLNITPSGDFYQPKTSGQQAQQQVMNASSTSAGFGVGSGSMVGGTGP 932
                        .|:|:     .|:..:...:|....|.......::....:...:|..|....|
  Fly   360 ------------SSDHQ-----PPAQRYVLQQTESVDANSMTQPTTTAPTQYHSTTGGSVKPPAP 407

  Fly   933 AAGEFPVRKQQVYDVFHPPPLP--KNSSGSNMFM--PLHPTRG-----SHPPPVGQPPDVVSLKS 988
                 |.|..:.:.....||.|  :.|||.:..:  ..:|..|     |........||.|||.:
  Fly   408 -----PPRTCEKHKPPAKPPKPEKEKSSGKHCHVGHSCNPCLGHFRWKSAEKSAVPAPDNVSLDA 467

  Fly   989 QNSIESILSAKSPAISEYGMYAKRHVPQAVRHVPKY----------------PSDSESIGSGVHG 1037
            .:       ..||....:.:.::|...|...|..|:                |..:.......:|
  Fly   468 YD-------LASPCCDTHCVPSRRRHRQHKEHTHKHKHRDRERVESKEQRVRPKSTSHASPNANG 525

  Fly  1038 GYG-GFLQSNHMPGNRHTQLFPTFGPGGRGNRRSSPLTLPSPPPQQQLQQLPAATAPHDSVGIPT 1101
            |.| |....:|...:.|.|          ..::...........|||.||.|..|.||
  Fly   526 GAGSGHHHHHHHHHHSHEQ----------QQQQQQQQQQQQQQQQQQQQQQPIQTVPH------- 573

  Fly  1102 DLDYHPHHHTQTNAMPHPHPHP----------HAPYLDYGHGL 1134
                  |||     .||...:|          .:.|.|...||
  Fly   574 ------HHH-----YPHQMHNPCQVQSQSGSTRSRYFDLASGL 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007	4/29 (14%)
		PDZ_signaling	439..516	CDD:238492	13/77 (17%)
		PDZ_signaling	533..592	CDD:238492	17/61 (28%)
		PDZ_signaling	1290..1369	CDD:238492
		PDZ_signaling	1497..1576	CDD:238492
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
ssp6	NP_001286952.1	PDZ_signaling	130..216	CDD:238492	23/95 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900