Protein Alignment Dlg5 and Lnx2

DIOPT Version :9

• Sequence 1: NP_609505.1
• Gene: Dlg5 / 34573
• FlyBaseID: FBgn0032363
• Length: 1916
• Species: Drosophila melanogaster
• Sequence 2: NP_001101799.1
• Gene: Lnx2 / 360761
• RGDID: 1308222
• Length: 686
• Species: Rattus norvegicus
• Alignment Length: 577
• Identity: 116/577 - (20%)
• Similarity: 192/577 - (33%)
• Gaps: 206/577 - (35%)

  Fly  1053 HTQLFPTFG------PGGR-----------GNRRSSPLTLPSPPPQQQLQQLPA--ATAPHDSVG 1098
            |||:....|      ||..           |.|.|:|..||.......|.. ||  .:|..|||.
  Rat   157 HTQIEGETGSTVIDPPGPSPPETDCLGTVPGERNSTPAPLPVWTEDPGLDN-PAFEESAAADSVQ 220

  Fly  1099 IPTDLDYHPHHHTQTNAMPHPHPHPHAPYLDYGHGLGIGPYMGVGGG----VSGVGGAIYEGGTF 1159
            .|..|   |.....|..:     |...||:..|..:       |||.    ::.|...:|..|..
  Rat   221 QPLSL---PEGEITTIEI-----HRTNPYIQLGISI-------VGGNETPLINIVIQEVYRDGAI 270

  Fly  1160 PRKKDNQRLRIPSNPSVASKSSSMVKNSSGSIDHHYVTSTGPVSGGSMSASSSDRAPMSLMSSSI 1224
            .|..     |:.:...:...::..:.|    :.|:|.                 ||.:|
  Rat   271 ARDG-----RLLAGDQILQVNNCDISN----VSHNYA-----------------RAVLS------ 303

  Fly  1225 HNSYGANIAGGNGTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGD 1289
                                           .|...:|:.||.....||   .:|..||...|.|
  Rat   304 -------------------------------QPCSTLHLTVLRERRFGS---RANNHADGSAPRD 334

  Fly  1290 -LRRVTIDKRD--KSLGITIQCNNNGGGIFVSTVADKSTAMRAG-LQVGDQLLEVCGINMRAATQ 1350
             :.:|.:.|||  :.|||.:....:..|:|:..:.:...|.:.| |...|::|.:.|.:::..|.
  Rat   335 EVFQVLLHKRDSAEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKQGTP 399

  Fly  1351 EIAANVLRQCGDSFTMLVQYNPEKFPSIEYEGAHNLEPESPINHSGSPTPRNSPRPPARNSLFPL 1415
            |:||::::..|:...:                        .|...|.|.|.|..|....:|
  Rat   400 ELAAHIIQASGERVNL------------------------TIARPGKPQPSNGSREAGAHS---- 436

  Fly  1416 PMQPQAPS-TRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDE 1479
            ....|.|| :||                          ||.:|:              |..|..:
  Rat   437 SNHAQPPSHSRP--------------------------SSHKDL--------------TRCVTCQ 461

  Fly  1480 EPKPSLPPPPASVPAETLRYVTLHMDKSKNLGIKLFG--GNKVG---IYVHDVAV-GSPSDHAGI 1538
            |                 :::|:..:..::||:.:.|  |:|.|   |:|..|.. |..:....|
  Rat   462 E-----------------KHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRI 509

  Fly  1539 RKGDQILEYNGVDLSGVTAEQA-----ANEISKLTDTVTMLVQNKLHTLKQIKDEPG 1590
            ::||.:|..||:||:.::..:|     |:..|.......:.||......:..:::||
  Rat   510 KRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVILKALEVQIAEEAAQATEEQPG 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	20/81 (25%)
		PDZ_signaling	1497..1576	CDD:238492	22/89 (25%)
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
Lnx2	NP_001101799.1	mRING-HC-C3HC3D_LNX2	46..90	CDD:319694
		PDZ	229..315	CDD:214570	22/160 (14%)
		PDZ	335..421	CDD:214570	21/109 (19%)
		PDZ_signaling	462..538	CDD:238492	21/92 (23%)
		PDZ_signaling	595..679	CDD:238492

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810