DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and CG43707

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_001260005.1	Gene:	CG43707 / 33601	FlyBaseID:	FBgn0263846	Length:	2021	Species:	Drosophila melanogaster

Alignment Length:	1286	Identity:	239/1286 - (18%)
Similarity:	413/1286 - (32%)	Gaps:	444/1286 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SQEEESSEYVGYDNTLRPPSNSSGSTTAANMS----NNNGPSKGVSSGVGVSGISGGNGANYDIL 76
            |..|::.|||          |.:.:..|.|.|    :|:.|.:..:|
  Fly   495 SPSEQNVEYV----------NVNAAAVALNESFDYESNSLPRRACTS------------------ 531

  Fly    77 QAQYKSALLELNTLRHQHANTKRRCDELATE---LTLYQEHYV-----------ADRNKFTDMVE 127
            ...:.|     |:|..:|..   ...||.|:   |...|.|.:           .|..::.|..|
  Fly   532 HTDFYS-----NSLPRRHIT---ESSELMTDSVPLDFSQSHLLPPPSEYCKNDDEDVEEYYDEDE 588

  Fly   128 ESARFKRLLLETQNQQS-----QQAQNGNSQVPPVGSGNPYYFGKTQGCDGSCSEKLAELKKERN 187
            :...      ||::..|     |.||:....:.|....:|:              :..:|:::..
  Fly   589 DHPH------ETESYSSEVCMEQAAQHRRMSMLPQMIDSPF--------------RRDDLRRQSM 633

  Fly   188 MVAVEREKYKKSYIELEKDRNYYRERGDENQKLKV-LLSQESKNVLSLTEELNQLLSEKDNVLQE 251
            .|..:.||    .|:....|:.:|.|.      || ....|...|..:.:|....:..|.::
  Fly   634 PVYGQTEK----LIDGFGPRSSFRRRD------KVSCFPDEPPAVQEVRDEQEIFIDFKPHI--- 685

  Fly   252 HQKMSDDLVLANKEIER----LKKDEQLARAEIKVLQL-------ANADLKKRDLLKSRDSSWSK 305
            ..|.|..|.|.:::..:    ::|.:|...|:...|.|       ...:::|.:|..|.:.....
  Fly   686 SPKPSPKLQLKHRKQHKAEIAMRKMQQQRMAQAAALTLPKPKSQPVEVEVRKVELEPSDEEEDED 750

  Fly   306 EFPSGKELENSKELEKLRKSLEKALSEVERSSQDAEEAKRVRDWAISQREKIVQERDSVKTLCDK 370
            |....:|.::.:|::...:.||..|.|.|                                   :
  Fly   751 EVSEPEEEDDGEEIDDDEQKLETDLQEDE-----------------------------------E 780

  Fly   371 MRHERDKAISDSLMAIRDSEKIKKQKDEAQKKIDLLKEQMEQQERQNLDSNASGSRRSFRPSSYE 435
            ..:|........::...|:|.|:.::.:.:|:...|.:..|.:..:.  ...:|.|....|:|..
  Fly   781 PLYENITPCGCRVVPTSDAEDIQDKRSQFRKRSVSLDDDYEAKASET--PTPTGLRLPSTPASPC 843

  Fly   436 GEDLLEVELSGYEHTSDLGIILDDSNKRKLVCGVTSSSPACGKLKINDVICKVNNLDCQSLSKRM 500
            .::|| ..:|.|..:..|.    :.|.|....|:.:.|      ::..:..:..::...|.|..:
  Fly   844 RDELL-ANVSTYPSSDSLA----NDNTRDHSDGIWNES------QVTVLTAEQRDISDGSYSSNL 897

  Fly   501 VLDEIRACAPRSLLLVSRTRHSKRHAYSVQLKTRDRDCPHGLQLDMGVFIAKIEQNSLAFYEPEL 565
            :|                |..|||....:|.:.|                :.::.::|.|.|...
  Fly   898 LL----------------TPSSKRKNLLLQHQQR----------------SSVDTDALDFEEQSP 930

  Fly   566 DVGDRVLSINNKSMDSVQSIEEVMQLMNDPRSDGLNLFALKYVQDQLPP---GMTTSSAQ-TDSI 626
            ..|             :|::.::::......|...:      .|..:||   .:|.|:.| .||.
  Fly   931 TYG-------------LQTLPKIIKTPTPTTSRPTS------TQPMMPPPAIAVTPSTNQILDSC 976

  Fly   627 DSMQHVSSAGGGGGSGPSSATKHPSRFAEFFFRKLKFSKPGTPEDNFEQEHDDA----IAALDSV 687
            .|......:....||.|.:             |:|.|:...|     :|.|.||    :.|.|..
  Fly   977 ISSPLPKRSMVARGSVPDA-------------RQLMFTSGAT-----KQRHSDASFLPMGAADYA 1023

  Fly   688 LSENSSEKSKENLFNRKKRTKKEKEASKSMGTWPRTNISHENPTGTMRGN-EKKRALMSLFTAGP 751
            .|.:.||.|          |..::.|:       .|:.|...|..|.... ||..|..|..:|..
  Fly  1024 RSADISECS----------TNTDEYAT-------CTDTSKRTPVSTQSSQLEKTHAGSSFESASS 1071

  Fly   752 INVDKDDELMGEVGVPEKQPAALIQDQLPPPL---------PPQMSKPLAHIRGS---NGGAIKT 804
            :...::|.|..:....:|| ..|.:.||..|:         .|..|.......||   .|.|||:
  Fly  1072 LYSMREDLLQHDEKERDKQ-TTLTKAQLKSPIGSVAELTRKSPSHSISSTTSSGSCPVLGAAIKS 1135

  Fly   805 HPNRNSNP--VSSGVSA--------LFPPG---PPNGM----------PNTSYPTHP-------- 838
             |.:.|.|  |:|.|::        ..|||   .|:.:          .::.|...|
  Fly  1136 -PAKESLPQTVASSVTSQMKVSSVECIPPGVKPKPDSISEDERSEVRYSSSGYYESPHEEDDEEQ 1199

  Fly   839 -----------------RHSLYGVTAEEINQK----PIQRAPLMGANARVKMPSQERYGTRPHSN 882
                             |.:...:..|:.|.:    ||::..   .::::..|.|...||..:.:
  Fly  1200 GTRSKARRLRQEDERKRRKTSMKLDIEKENMRALTSPIKKPT---GSSKITSPEQSISGTMDNGS 1261

  Fly   883 HRLSLNITPSG-DFYQPKTSGQ---QAQQQVMNAS------STSAGFGVGSGS------------ 925
                   :||. ..::||...|   .:::.|:.|:      :|...||:.|||
  Fly  1262 -------SPSKMKRFRPKIRRQLRKSSREDVLAAAAVRRSRATPTIFGLSSGSGDTELLLDASMS 1319

  Fly   926 --MVGGT---------GP-AAGEFPVRKQQVYD----VFHPPPLPKNSS---GSNMFMPLHP-TR 970
              .|.||         .| :|.:.|..:..|..    |..|.|..|..|   .:::..|..| |.
  Fly  1320 TGAVAGTTTSAVTSVSAPSSASKLPTSESSVTTQPEAVVAPLPAKKPHSCATPTSLLSPKLPTTS 1384

  Fly   971 GSHPPPVGQPPDVVSLKSQNSIESILSA-----------------------------------KS 1000
            |:......   |...||:: ||||:.|.                                   :|
  Fly  1385 GTQSKSTS---DTFQLKAK-SIESLRSVSPGSDSVFYSEADGNAASGEQSHCHHCGKEMEGKQQS 1445

  Fly  1001 PAISEYGMYAKRHVPQAVRHVPKYPSD-----------------------SESIGSGVHGGYGGF 1042
            ..|||....:...:|...:.:.|.|||                       ||....|..|.:...
  Fly  1446 NTISELAGDSVESIPYIEQDIVKPPSDFADSPVTTKTTQRLYKKMDKRFRSEERYHGERGRHYKT 1510

  Fly  1043 LQSN---------HMPGNRHTQLFPTFGPGGRGNRRSSPLTLPSPPPQQQL 1084
            .|.|         .:|...:|   |...|.|     |||..||.....|.:
  Fly  1511 RQENIRAKSEERGRIPSLPNT---PVLRPAG-----SSPCVLPDTEQSQHI 1553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211	32/179 (18%)
		CENP-F_leu_zip	229..360	CDD:287450	23/141 (16%)
		DUF1090	<326..408	CDD:284007	11/81 (14%)
		PDZ_signaling	439..516	CDD:238492	12/76 (16%)
		PDZ_signaling	533..592	CDD:238492	6/58 (10%)
		PDZ_signaling	1290..1369	CDD:238492
		PDZ_signaling	1497..1576	CDD:238492
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
CG43707	NP_001260005.1	PHA03369	<987..1394	CDD:223061	94/456 (21%)
		PDZ_signaling	1702..1775	CDD:238492
		PH	1792..1894	CDD:278594
		PH-like	1792..1893	CDD:302622
		PH-like	1911..2011	CDD:302622
		PH	1921..2014	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900