DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and Card10

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	XP_038935185.1	Gene:	Card10 / 315120	RGDID:	1304949	Length:	1109	Species:	Rattus norvegicus

Alignment Length:	609	Identity:	127/609 - (20%)
Similarity:	223/609 - (36%)	Gaps:	132/609 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1353 AANVLRQCGDSFTMLVQYNPE----KFPSI-EYEGAHNLEPESPINHSGSPTPRNSPRPPARNSL 1412
            |.::||:..:.       :||    .|.|: :..|:..|:|.||...|.|          :.:|:
  Rat   568 AGSILRRQREE-------DPEPPKRSFSSMSDITGSVTLKPWSPGLSSSS----------SSDSV 615

  Fly  1413 FPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATT-------TTTTA 1470
            :||. :|:....| |......:.||..   .|...:..:.||....||.||.:       :....
  Rat   616 WPLG-KPEGLLAR-GCGLDFLNSSILR---WDPAVSSPEASSEPLCPSLAAASRLEANGCSLLEL 675

  Fly  1471 SATSTVYDEEPKPSLPPPPASVPAETLRYVTLHMDKSKNLGIKLFGGNKVGIYVHDVAVGSPSDH 1535
            |....|....|...|.|                .|||.: .:.:.|....|..|..|..|..|
  Rat   676 SLAIRVSGWSPSGGLDP----------------QDKSPD-SLPILGDRWSGAVVRRVLSGPGS-- 721

  Fly  1536 AGIRKGDQILEYNGVDLSGVTAEQAANEIS-KLTDTVTMLVQNK----LHTLKQI--KDEPGDSF 1593
            |...:.:...|.:|::.:|:.||.....:. ..:.|:..|:.:|    .|....:  |....:.|
  Rat   722 ARTEQKEPRAEGSGLEGTGLEAEVQQRTLPWNQSSTLPFLLDSKACQSFHEALDVWAKGPGAEPF 786

  Fly  1594 YIRVGFDRTGELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRK-ECGIIPSQMKVEE 1657
            |||..|......:...|.....|:|.:.:..:... ..|...::|.:..|. :.|.:|:..:.::
  Rat   787 YIRANFSLPERADPHALCVKAQEILRLVDPAYKRR-QEWFCTRVDTLTLRDLDRGTVPNYQRAQQ 850

  Fly  1658 ELRSGEVVDCDTGTAR----RGSTSARRSFFRRKKNQRSSSRDSTEIASFSNTQLSFFPDLGLLN 1718
            .|   ||.:....::|    |.:...|.....|.|....::.||.|       ||...|...|
  Rat   851 LL---EVQEKYLISSRHRSPRSNLKKRALGLVRPKPAGGTAGDSAE-------QLPADPCSEL-- 903

  Fly  1719 DDGGALSYQRVELLDSPIRRPVLIIGPLSECLMVRLTIDFSNL------FKLCEVTAM----DCS 1773
             :.....|..|..|.....|||::   |.|||..||..:..:|      |::|...::    .|:
  Rat   904 -ERSLKPYSLVRPLLVSALRPVVL---LPECLAPRLIRNLLDLPSSRLDFQVCSAESLSGEEQCT 964

  Fly  1774 QEA--------MEEGLKENIFVDYRRRGNKFECTTVEAISNACKNDRRHCILDVSISAVERLQRL 1830
            ..|        ...||           |::     :.||..:.  .::||:|::....|..|...
  Rat   965 SSAPGAPKAWPASAGL-----------GSR-----IRAIQESV--GKKHCLLELGARGVRELVHS 1011

  Fly  1831 QIYPIVLLLRFKSAKQIRDIRDF-----GTDKISAKAAKEMYERAMKLETDYKQYISAVIPGVSI 1890
            ::||||:.:.. :.|.:|:||..     ..|....:..:...:....|...:.|     :|..:.
  Rat  1012 EVYPIVIHVEV-TEKNVREIRSLLGRPGWRDSELLRQCRGSEQWLWGLPCSWVQ-----VPAHAW 1070

  Fly  1891 KH---MCTQIKDAVDKEQDKLLWV 1911
            .|   :...::..:.:||.:|:||
  Rat  1071 GHAEELAKVVRGRILQEQARLVWV 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	3/15 (20%)
		PDZ_signaling	1497..1576	CDD:238492	17/79 (22%)
		SH3_DLG5	1594..1657	CDD:212794	12/63 (19%)
		Guanylate_kin	1737..1904	CDD:279019	37/192 (19%)
		NK	<1773..1905	CDD:302627	24/147 (16%)
Card10	XP_038935185.1	CARD_CARD10_CARMA3	76..161	CDD:260069
		Smc	<196..>499	CDD:224117
		SH3	784..849	CDD:418401	13/65 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810