DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and PsGEF

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_996333.4	Gene:	PsGEF / 31224	FlyBaseID:	FBgn0264598	Length:	2777	Species:	Drosophila melanogaster

Alignment Length:	1744	Identity:	322/1744 - (18%)
Similarity:	525/1744 - (30%)	Gaps:	641/1744 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KMASG--DLSLTSTSSQEEESSEYVGYDNTLRPPSNSSGSTTAANMSNNNGP------------- 52
            |..||  :||:::| |....:||..|..:.:   |.|..:|:.:.::..:.|
  Fly  1368 KRLSGVEELSMSAT-SDIYSTSEAEGVTSVI---SQSHSTTSDSQITVRSSPIVLDKLAVCRHCH 1428

  Fly    53 SKGVSSGVGVSGISGGNGANYDILQAQYKSALLELNTLRHQHA-NTKRRCDEL------ATEL-- 108
            .....||.|.:...||.|.|     ....:.:|..|:|:.||: ::..||.:|      |||:
  Fly  1429 KNCQQSGPGGARPGGGGGVN-----NSSSTPVLLCNSLKVQHSQSSPNRCCKLSNGIAGATEMAN 1488

  Fly   109 --------------------TLYQE---HYVADRNKFTDMVEESARFKRLLLETQNQQSQQAQNG 150
                                |:..|   ..||..::......||...:.:..|....||:...:.
  Fly  1489 PKNSNRTGTGTGSVTSMSSSTITGELSSKVVASSSRRETGDTESDVAQLITDEISQSQSEATDDS 1553

  Fly   151 NSQVP----PVGSGNPYYFGK-------------------TQGCDGSCSEKLAELKKERNMVAVE 192
            ...:|    ..|.|||...|.                   :.|..|...:.|...::.|.:..:.
  Fly  1554 VGAMPNSSRSAGEGNPVITGSRLRHLDPPVSVSSLPNGHCSAGVGGGSPKPLPPPRRTRVVAQMC 1618

  Fly   193 REKYKKSYIELEKDRNYYRERGDENQKLKVLLS-QESKNVL-----------SLT---------- 235
            :|.                .|...||::|.::: .|:..::           |.|
  Fly  1619 QEP----------------PRPKANQQVKAIVTITETARIMRSSPTKGSGSGSATGTGSVGGSPA 1667

  Fly   236 -----------EELN--QLLSEKDNVLQEHQ--KMSDDLVLANKEIERLKKDEQLARAEIKVLQL 285
                       |:..  ||..:|    .|||  |:.:........:|:.::||||:...|.:.||
  Fly  1668 KYAACHCRCTPEDFTHAQLSPDK----MEHQTCKLLESPKQTTTTLEQKQEDEQLSLMLIGLAQL 1728

  Fly   286 ANADLKKRDLLKSRDSSWSKEFPSGKELENSKELEKLRKSLEKALSEVERSSQD----------A 340
            |.|          ......:..|  ||..::..:..:..:.:..|::......|          .
  Fly  1729 APA----------ATLCGQERIP--KEENSTPTIAVVPPTPDSVLTKTSTHVWDNSGCSSNGGGT 1781

  Fly   341 EEAKRVRDWAISQREKIVQE--RDSVKTLCDKMRHERD---KAISDSLMAIRDSEKIKK-QKDEA 399
            .............|:.|::.  .||    ||:...:.:   :.:|.:|........::| ..|:.
  Fly  1782 STTSTATTTTKQPRQAIIENIPEDS----CDESPLDEEPPYRPMSSALRRFGTMSSLEKLPSDDR 1842

  Fly   400 QKKIDLLKEQMEQQERQNLDSNASGSRRSFRPSSYEGEDLLEVELSGYEHTSDLGIILDDSNKRK 464
            ..:.|.|.:.::                ||:|:.::|.       |......|    .|..::|.
  Fly  1843 MDEADELDDDLD----------------SFKPNGHDGN-------SPQNEEDD----EDADSERA 1880

  Fly   465 LVCGVTSSSPACGKLKINDVICK---VNNLDCQSLSKRMVLDEIRACAPRSLLLVSRTRHSKRHA 526
            ||.....:|.:.|.:...:.:..   .|........|....:|.||...:.|...:.....::|.
  Fly  1881 LVQNDLGASSSSGVIVNGEGLASGAWTNRAGAYVSDKMSFFEESRAFIDKYLGRWNAGDAQQQHQ 1945

  Fly   527 YSVQLKTRDR--DCPHGLQLDMGVFIAKIEQNSLAFYEPELDVGDRVLSINNKSMDSVQSIEEVM 589
            .....:|.::  :|..|                       ...|:.|........|   :.::.:
  Fly  1946 QGTASETDEQMDECTSG-----------------------ATSGEEVWGTPTSGGD---NDDQDL 1984

  Fly   590 QLMNDPRSDGLNLFALKYVQDQLPPGMTTSSAQTDSIDSMQHVSSAGGGGGSGPSSATKHPSRFA 654
            ||:|...:            ...|...:||....|..:.|......     :.|.:|:.......
  Fly  1985 QLINSENT------------HSSPTKSSTSLNDDDDTELMMDELLM-----APPMTASTIRGLLP 2032

  Fly   655 EFFFRKLKFSKPGTPEDNFEQEHDDAIAALDSVLSENSSEKSKENLFNRKKRTKKEKEASKSMGT 719
            .|:.|:|        |..||:|            :|:..||::::..:.||     .||:
  Fly  2033 RFYRRRL--------EPLFEEE------------TESDEEKTQQDSDDIKK-----GEAT----- 2067

  Fly   720 WPRTNISH--ENPTGTMRGNEKKRALMSLFTAGPINVDKDDELMGEVGVPEKQPAALIQDQLPPP 782
               || .|  |:..|:...:|.                                        .||
  Fly  2068 ---TN-GHYLEDSAGSSSDSES----------------------------------------VPP 2088

  Fly   783 LPPQMSKPLAHIRGSNGGAIKTHPN---RNSNPVSSGVSALFP--------PGP---PNGMPNTS 833
            .||.:.:|:...|..:..|.....|   .:...:.|.|..|.|        |.|   ...:|.|:
  Fly  2089 APPLVPRPVVPDREEDPSAEGQQENLAMEDQEDLHSSVERLLPNLATSAMGPRPLLTTRLLPTTA 2153

  Fly   834 YPTHPRHSLYGVTAEE-INQKP--IQRAPLMG--------ANARVKMPSQERYGTRPHSNHRLSL 887
            ....|...|...:.|. ::|:|  :....|.|        .::|....|..:....|...:....
  Fly  2154 IDPQPPAVLVASSCEYLLDQRPSSVPGRDLAGGSIGTTTMTSSRPTPLSPAKAAATPIGMNATMT 2218

  Fly   888 NITPSGDFYQPKTSGQQAQQQVMNASSTSAGFGVGSGSMVGGTGPAAGEFPVRKQQVYDVFHPPP 952
            ..|.:.....|..:.......:.:||.|::..|..||.            |.|       |.|||
  Fly  2219 TKTTTTTMMTPSRAPSSTISTISSASDTTSSGGRASGR------------PPR-------FVPPP 2264

  Fly   953 LPKNSSGSNMFMPLHPTRGSHPPP---VGQPPDVVSLKSQNSI---ESILSAKSPAISEYGMYAK 1011
                                 |||   :....|:::.:::..:   :|..:|.|......|..|.
  Fly  2265 ---------------------PPPRRLLLTQTDLIAGQAKTELPRKKSGATADSGCSVAVGDAAS 2308

  Fly  1012 RHVPQAV--RHVPKYPSDSESIGSGVHGGYGGFLQSNHMPGNRHTQLFPTFGPG----------G 1064
            ...|.|:  |.:|..||.| |:.|.|            .|....:.:..|...|          .
  Fly  2309 ASDPTAIGSRTMPSTPSTS-SLASAV------------APKRPSSTIIETCLLGAPRPASATSSA 2360

  Fly  1065 RGNRRSSPLTLPSPPPQQQL----QQLPAA-----TAPHDSVGIPTDLDYHPHHHTQTNAMPHPH 1120
            ..:|.:.|:. .|||.|.|.    |..|||     ||..|:..:|               |||.
  Fly  2361 TASRMAKPIR-QSPPTQHQSQPRGQSCPAAVPAPSTAAPDAPTVP---------------MPHA- 2408

  Fly  1121 PHPHAPYLDYGHGLGIGP----YMGVGGGVSGVGGAI-YEGG------------TFPRKKDNQRL 1168
                        |.|:.|    .:.:...:.|....| ||.|            ||.|......|
  Fly  2409 ------------GCGLSPRLEMRLALNHDILGDEDLICYEPGPDLTTILGHDLSTFHRLTGRDLL 2461

  Fly  1169 -RIPSN---PSVASKSSSMVKNSSGSIDHHYVT-STGPVSGGSMSASSSDRAPMSLMSSSIHNSY 1228
             |..:|   |..|..|.|..:||  .:|...|. ...|:|.|::..|:|:..|.:..|||.|.:.
  Fly  2462 SRSATNRVQPKEAVISYSQQRNS--KMDTPTVNRRPRPLSAGALGGSTSNSNPNNSRSSSSHGNS 2524

  Fly  1229 ----GANIAGGNGTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGD 1289
                |...||....|....|...|||.:||              .|||||....|..|
  Fly  2525 PLGGGLTRAGVEPVGQQQLVVQAGGGSAGR--------------VGGGSGSAGGNSTA------- 2568

  Fly  1290 LRRVTIDKRDKSLGITIQCNNNGGGIFVSTVAD-KSTAMRAGLQVGDQLLEVCGINMRAATQEI- 1352
                              |::|.||   |.:.| :..|.|..:....|....|.:....:|..:
  Fly  2569 ------------------CSSNRGG---SKLGDLEILARREKIYSMSQSRSGCRVRETTSTTTLM 2612

  Fly  1353 -AANVLRQCGDSFTMLVQYNPEKFPSIEYEGAHNLEPESPINHSGSPTPRNSPRPPARNSLFPLP 1416
             .|..:|...||         ||                                  |:|.:|..
  Fly  2613 AMATEMRSGMDS---------EK----------------------------------RDSSWPKR 2634

  Fly  1417 MQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTT------------- 1468
            ....|..||..|                        |:|.|...:.:|||||
  Fly  2635 AAAAASLTRTRS------------------------STSMDGAGAISTTTTTTTTMTEEAFLETE 2675

  Fly  1469 ------------------TASATST-------VYDEEPKPS----------LPP 1487
                              |||:||:       ...|:|:||          |||
  Fly  2676 VGRSKRLINFIKRRNSEITASSTSSTPNFSDGAIGEQPQPSHSQSSLLLQKLPP 2729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211	35/223 (16%)
		CENP-F_leu_zip	229..360	CDD:287450	27/176 (15%)
		DUF1090	<326..408	CDD:284007	14/97 (14%)
		PDZ_signaling	439..516	CDD:238492	14/79 (18%)
		PDZ_signaling	533..592	CDD:238492	7/60 (12%)
		PDZ_signaling	1290..1369	CDD:238492	15/81 (19%)
		PDZ_signaling	1497..1576	CDD:238492
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
PsGEF	NP_996333.4	DUF4799	<102..209	CDD:292674
		C2	286..>381	CDD:278593
		PDZ_signaling	644..716	CDD:238492
		RhoGEF	831..1000	CDD:295373
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900