DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlg5 and Cytip

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_001012086.1	Gene:	Cytip / 311047	RGDID:	1307990	Length:	359	Species:	Rattus norvegicus

Alignment Length:	337	Identity:	66/337 - (19%)
Similarity:	117/337 - (34%)	Gaps:	104/337 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1185 KNSSGSIDH-------HYVTSTGPVSGGSMSASSSDRAPMSLMSSSIHNSYGANIAGGN-----G 1237
            ::|:|::::       .|.|.|||:       :..|...:.:::.::     |.:..|.     .
  Rat    10 QSSNGNLEYCADSAYSSYPTLTGPL-------TVEDNRRIQMLADTV-----ATLPRGRKQLALA 62

  Fly  1238 TGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRVTIDKRDK-S 1301
            ..||:|                                       ||.| ...:.||::|:|. :
  Rat    63 RSSSLG---------------------------------------DFSC-SQRKVVTVEKQDNGT 87

  Fly  1302 LGITIQC----NNNGGGIFVST----VADKSTAMRAGLQVGDQLLEVCGINMRAATQEIAANVLR 1358
            .|..||.    |.|.....|.|    |.:.|.|..|||||||....|.|::....|.:...:::|
  Rat    88 FGFEIQTYRLQNQNICSSEVCTMICKVQEDSPAHCAGLQVGDIFANVNGVSTEGFTHKQVVDLIR 152

  Fly  1359 QCGDSFTM--------------------LVQYNPEKFPSIEYEGAHNLEPESPINHSGSPTPRNS 1403
            ..|:..|:                    |.|...:|:  :|....| |:.:..::...:.:|...
  Rat   153 SSGNLLTIETLNGTMIHRRAELEAKLQTLKQTLKKKW--VELRSLH-LQEQRLLHGDAANSPNLE 214

  Fly  1404 PRPPARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTT 1468
            ......:|||...:.|        |.|.|....:..:|...|..:...:.|..|..:|.:..:..
  Rat   215 NMNLDESSLFGNLLGP--------SPAFLDRPRLSSESSCKSWLSSLTVDSEDDYGTSVSEDSIR 271

  Fly  1469 TASATSTVYDEE 1480
            .|.:..|..|:|
  Rat   272 GAFSRQTSTDDE 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	28/107 (26%)
		PDZ_signaling	1497..1576	CDD:238492
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
Cytip	NP_001012086.1	PDZ_signaling	76..161	CDD:238492	27/84 (32%)
Cytip	NP_001012086.1	Interaction with CYTH1. /evidence=ECO:0000250	166..188		2/21 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900