DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and Dlg5

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_001358932.1	Gene:	Dlg5 / 305645	RGDID:	1308753	Length:	1925	Species:	Rattus norvegicus

Alignment Length:	2078	Identity:	535/2078 - (25%)
Similarity:	869/2078 - (41%)	Gaps:	580/2078 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 NYDILQAQYKSALLELNTLRHQHANTKRRCDELATELTLY---QEHYVADRNKFTDMVEESAR-- 131
            :|:.|:.|...|:.:|.:|::||.|..:||:|:|.|...|   ....::|:.:..|.|:...|
  Rat   187 DYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTQLKDDVDMLRREN 251

  Fly   132 ----------------FKRLLLETQNQ----QSQQAQ----NGNSQVPPVGSGNPYYFGKTQGCD 172
                            .|||..|.|.:    ::||.|    ||:|::.     |..|
  Rat   252 GKLRRERNLLQQSWEDMKRLREEDQKEIGDLRAQQQQVLKHNGSSEIL-----NKLY-------- 303

  Fly   173 GSCSEKLAELKKERNMVAVEREKYKKSYIELEKDRNYYRERGDENQKLK---VLLSQESKNVLSL 234
            .:..:||..:||:.:.:   |::|.:.......|.:...:.|:|||:|:   .:|:|:....:.|
  Rat   304 DTAMDKLEVVKKDYDAL---RKRYSEKVAMHNSDLSRLEQLGEENQRLQKQTEMLTQQRDTAIQL 365

  Fly   235 T--------------EELNQLLSEKDNVLQEHQKMSDDL-------VLANKEIERLKKDEQLARA 278
            .              .||::..::..::..|.:.:..:|       |...||.|:.|::.....:
  Rat   366 QHQCALSLRRFETIHHELSKATAQNKDLQWEMELLQSELTELRSKQVKTAKESEKYKEERDAVYS 430

  Fly   279 EIKVL------------------QLANADLKKRDLLKSRDSSWSKEFPSGKELE----------- 314
            |.|::                  :||.:.||         ||.|::..:.:|:|
  Rat   431 EYKLIMSERDQVISELDKLQTEVELAESKLK---------SSTSEKKAASEEVEALRQIKDTVTM 486

  Fly   315 ----NSKELEKLRKSLEKALSEVERSSQDAEEAKRVRDWAISQREKIVQERDSVKTLCDKMRHER 375
                .:||:|.|||..:....|::.:.|:|:.||..||||..:|:|||.||||::||||.:|.||
  Rat   487 DAGRANKEVEVLRKQCKALCQELKEALQEADVAKCRRDWAFRERDKIVAERDSIRTLCDNLRRER 551

  Fly   376 DKAISDSLMAIRDSEKIKKQKDEAQKKIDLLKEQMEQQERQNLDSNASGSRRSFRPSSYEG---E 437
            |:|:|:...|:|..:..:|||::..:::..||||||.|    |:..|. .|:....||::.   .
  Rat   552 DRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMECQ----LEKEAR-FRQLMAHSSHDSAIDT 611

  Fly   438 DLLEVELSGYE---HTSD-----LGIILDDSNKRKLV---CG-----VTSSSPACGKLKINDVIC 486
            |.:|.|....|   .|.|     ||..:.:.......   ||     |...|.|.|:|::||.:.
  Rat   612 DSMEWETEVVEFVRETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIADGRLRVNDWLL 676

  Fly   487 KVNNLDCQSLSKRMVLDEIRACAPRSLL-------LVSRTRHSKRHAYSVQLK---TRDRDCPHG 541
            ::|::|..:..|:..:        ::||       :|.|.|.|........|.   :..:|  .|
  Rat   677 RINDVDLINKDKKQAI--------KALLNGEGAINMVVRRRKSLGGKVVTPLHINLSGQKD--SG 731

  Fly   542 LQLDMGVFIAKIEQNSLAFYEPELDVGDRVLSINNKSMD--SVQSIEEVMQLMND---------- 594
            :.|:.||:.|.:...|.|..|..|.||||:::||..::|  |:...|.:::...|
  Rat   732 ISLENGVYAAAVVPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLKVF 796

  Fly   595 PRS---DGLNLFALKYVQD-----------------------QLPPGMTTSSAQTDSIDSMQHVS 633
            |:|   .|.|:|  :.::|                       |......|....||.::..:.:.
  Rat   797 PQSSSWSGQNIF--ENIKDSDRMLSCRAHGPEVQAHNKRNLLQHNNSTQTDIFYTDRLEDRKELD 859

  Fly   634 SAGG---------GGGSGPSSATKHPSRFAEFFFRKLKFSKPGTPEDNFEQEHDDAIAALDSVLS 689
            .:||         .|.|.|:|....||                |.|           .:|:|..|
  Rat   860 HSGGSSSYLYKPFSGASSPASPQACPS----------------TSE-----------RSLNSFRS 897

  Fly   690 ENSSEK--------SKENLFNRKKRT-----------KKEKEASKSMGTWPRTNISHENPTGTMR 735
            :.|:|:        |:..|.:.:...           |.:.|.|.|.||||:..:...:....:.
  Rat   898 DTSAERGYGLVDVQSQRPLLSFETEVGPCGTVGAPLDKIDPEGSNSGGTWPKAVLGSTSGPEKLS 962

  Fly   736 GNEKKRALMSLFTAG----PINVDKDDELMGEVGV-----PEKQPAALIQDQLPPPLPPQMSKPL 791
            ..:|.:...|:|...    |....|.|.|:..:|:     |.|: |...:..|.||.||:.|..:
  Rat   963 VYKKPKQRKSIFDPNTFKRPQTPPKVDYLLPGLGLTHSPQPSKR-ADTPKGSLTPPKPPRRSDSI 1026

  Fly   792 --AHIRGSNGGAIKTHPNRNSNPVSSGVSALFPPGPPNGMPNTSYPTHPRHSLYGVTAEEINQKP 854
              .|       .::|.....:..|.|..|...|..||..|.    |:.|.|:           .|
  Rat  1027 KFQH-------RLETSSESEATLVGSSPSTSPPSAPPPSMD----PSEPMHA-----------SP 1069

  Fly   855 IQRAPLMGANA------------RVKMPSQE-----------RYGTRPHSNHRLSLNITPSGDFY 896
            .::|.:..|::            .||.|..|           :...||.|        .||   :
  Rat  1070 PRKARVRIASSYHSEGDGDTSYLPVKKPCDEDLTSQKVDELGQKRRRPKS--------APS---F 1123

  Fly   897 QPKTSGQQAQQQVMNASSTSAGFGVGSGSMVGGTGPAAGEFPVRKQQVYDVFHPPPLPKNSSGSN 961
            :||.|......|.:.....:               |.:||.....|.    :.|..|...|...|
  Rat  1124 RPKISPVVIPAQCLEEQDCA---------------PVSGELSPEAQD----WSPYTLGHASRPGN 1169

  Fly   962 MFMPLHPTRGSHPPPVGQPPDVVSLKSQNSIESILSAKSPAISEYGMYAKRHVPQAVRHVPKYPS 1026
            ..  |:|.|    |.||..|.  |:....::.|||  ::|.   |.:.:.|.||.....||: .:
  Rat  1170 PL--LYPNR----PSVGTVPR--SMTPSTTVSSIL--RNPI---YTVRSHRVVPCGSPPVPR-DA 1220

  Fly  1027 DSESIGSGV-HGGYGGFLQSNHMPGNRHTQLFPTFGPGGRGNRRSSPLTLPSPPPQQQLQQLPAA 1090
            .|.|:.|.| |.|... |..:|...:.::::            |:|          |....||::
  Rat  1221 GSHSLSSSVQHQGRLS-LDLSHRACSDYSEM------------RAS----------QGSNSLPSS 1262

  Fly  1091 TAPHDSVGIPTDLDYHPHHHTQTNAMPHPHPHPHAPYLDYGHGLGIGPYMGVGGGVSGVGGAIYE 1155
            .    .:|..::|.:..
  Rat  1263 A----RLGSSSNLQFKA------------------------------------------------ 1275

  Fly  1156 GGTFPRKKDNQRLRIPSNPSVASKSSSMVKNSSGSIDHHYVTSTGPVSGGSMSASSSDRAPMSLM 1220
                      :|::||..|..   ..|::.:..||:.|. ..||.|.|..::.|.|....|.:
  Rat  1276 ----------ERIKIPLTPRY---PRSVMGSDRGSLSHS-ECSTPPRSPLNVDALSFCSQPQT-- 1324

  Fly  1221 SSSIHNSYGANIAGGNGTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFL 1285
                                             ..|.:|::.|...||     |:|..:.|  |:
  Rat  1325 ---------------------------------SASTLPRIAVNSSSH-----GERRKDRP--FV 1349

  Fly  1286 CPGDLRRVTIDKRDKSLGITIQCNNNGGGIFVSTVADKSTAMRAGLQVGDQLLEVCGINMRAATQ 1350
              .:.|.|.:.|..:.|||:| .:...|||:||.|...|.|.:|||:.||||||..|||:|:||:
  Rat  1350 --EEPRHVKVQKGSEPLGISI-VSGEKGGIYVSKVTMGSIAHQAGLEYGDQLLEFNGINLRSATE 1411

  Fly  1351 EIAANVLRQCGDSFTMLVQYNPEKFPSIEYEGAHN---------LEPESPINHSGSPTPRNSPRP 1406
            :.|..::.|..|:.|:|.||||.    |....:|:         ..|.|.:..|.:.||.:.
  Rat  1412 QQARLIIGQQCDTITILAQYNPH----IHQLNSHSRSSSHLDPAAAPHSTLQGSSAATPEHP--- 1469

  Fly  1407 PARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTAS 1471
               :.:.||..|.:.|.|.|..::..|.:.:.|.|
  Rat  1470 ---SVIDPLMEQDEGPGTPPAKQSTPSSRIVGDAS------------------------------ 1501

  Fly  1472 ATSTVYDEEPKPSLPPPPASVPAETLRYVTLHMDKSK-NLGIKLFGGNKVGIYVHDVAVGSPSDH 1535
                  .:.|:|.:                :.:.||: :||::|.|||..|::|.:|...||:..
  Rat  1502 ------KKTPEPRI----------------VFIKKSQLDLGVQLCGGNLHGVFVAEVEDDSPAKG 1544

  Fly  1536 A-GIRKGDQILEYNGVDLSGVTAEQAANEISKLTDTVTMLVQNKLHTLKQIKDEPGDSFYIRVGF 1599
            . |:..||.||||..:|:...|.|....|:.|..|::.:.||.:.....::|...|||||||..:
  Rat  1545 PDGLVPGDLILEYGNLDMRSRTLEDVYVEMMKPKDSIRLKVQYRHEEFTRVKGLSGDSFYIRALY 1609

  Fly  1600 DRTGELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRKECGIIPSQMKVEEE----LR 1660
            ||..|: |.:|.|.||::||||:|:..|.||.|.||:||....:.:.|.|||:..:::|    |.
  Rat  1610 DRLAEV-EPELSFKKDDILYVDDTLPQGMFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLS 1673

  Fly  1661 SGEVVDCDTGTARRGSTSARRSFFRRK-KNQRSSSRDSTEIAS---FSNTQLSFFPDLGLLNDDG 1721
            ..||.  |..||:..|.:||||||||| |::||.|:||.::.|   |||..:..|       :|.
  Rat  1674 MSEVK--DDNTAKMLSAAARRSFFRRKHKHKRSGSKDSKDLLSLDTFSNDSIPLF-------EDS 1729

  Fly  1722 GALSYQRVELLDSPIRRPVLIIGPLSECLMVRLTIDFSNLFKLCEVTAMDCSQEAMEEGLKENIF 1786
            .:|:||||:.:|....|||||:|||.:.:...|..:....|..|.:..|..||:|:|.|:|:.:|
  Rat  1730 VSLAYQRVQKVDCTSLRPVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLF 1794

  Fly  1787 VDYRRRGNKFECTTVEAISNACKNDRRHCILDVSISAVERLQRLQIYPIVLLLRFKSAKQIRDIR 1851
            |||:||...|:.|||.:|....:.: |||:||::..|:|||..:.|||||:.:|:||||.|::.|
  Rat  1795 VDYKRRSGHFDVTTVASIKEITEKN-RHCLLDIAPHAIERLHHMHIYPIVIFIRYKSAKHIKEQR 1858

  Fly  1852 D--FGTDKISAKAAKEMYERAMKLETDYKQYISAVIPGVSIKHMCTQIKDAVDKEQDKLLWVP 1912
            |  :..||::.:.:||.:|.|.|::.:|.:|.:.|:.|.::..:||||...|.:||.|:||:|
  Rat  1859 DPVYLRDKVTQRHSKEQFETAQKIDQEYSRYFTGVVQGGALSSICTQILAMVSQEQSKVLWIP 1921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211	41/224 (18%)
		CENP-F_leu_zip	229..360	CDD:287450	40/184 (22%)
		DUF1090	<326..408	CDD:284007	33/81 (41%)
		PDZ_signaling	439..516	CDD:238492	21/99 (21%)
		PDZ_signaling	533..592	CDD:238492	19/60 (32%)
		PDZ_signaling	1290..1369	CDD:238492	35/78 (45%)
		PDZ_signaling	1497..1576	CDD:238492	26/80 (33%)
		SH3_DLG5	1594..1657	CDD:212794	28/62 (45%)
		Guanylate_kin	1737..1904	CDD:279019	67/168 (40%)
		NK	<1773..1905	CDD:302627	55/133 (41%)
Dlg5	NP_001358932.1	Takusan	129..213	CDD:398477	9/25 (36%)
		Smc	<141..564	CDD:224117	121/468 (26%)
		Cep57_CLD_2	<545..585	CDD:372959	12/58 (21%)
		PDZ_signaling	620..707	CDD:238492	26/98 (27%)
		PDZ_signaling	722..790	CDD:238492	15/99 (15%)
		PDZ	1351..1433	CDD:214570	19/81 (23%)
		dbPDZ_assoc	1431..1506	CDD:406907	32/83 (39%)
		PDZ	1506..1588	CDD:214570	12/81 (15%)
		SH3_DLG5	1604..1666	CDD:212794	20/63 (32%)
		GuKc	1738..1914	CDD:214504	73/183 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353067
Domainoid	1	1.000	125	1.000	Domainoid score	I5359
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	502	1.000	Inparanoid score	I1300
OMA	1	1.010	-	-		QHG47148
OrthoDB	1	1.010	-	-		D123652at2759
OrthoFinder	1	1.000	-	-		FOG0005387
OrthoInspector	1	1.000	-	-		oto95632
orthoMCL	1	0.900	-	-		OOG6_106741
Panther	1	1.100	-	-	LDO	PTHR46360
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4317
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910