Protein Alignment Dlg5 and Pard3b

DIOPT Version :9

• Sequence 1: NP_609505.1
• Gene: Dlg5 / 34573
• FlyBaseID: FBgn0032363
• Length: 1916
• Species: Drosophila melanogaster
• Sequence 2: NP_001178737.1
• Gene: Pard3b / 301455
• RGDID: 1584992
• Length: 1203
• Species: Rattus norvegicus
• Alignment Length: 1137
• Identity: 228/1137 - (20%)
• Similarity: 368/1137 - (32%)
• Gaps: 404/1137 - (35%)

  Fly   213 RG-DENQKLKVL-LSQESKNVLSL--TEELNQLLSEKDNVLQEHQKMSDDLVL-----ANKE--- 265
            || :||.:.|.. |.||::.::.:  .|.|::..::..:|.::..| |..:||     .|:|
  Rat   234 RGIEENSRCKQEGLFQENECIVKINNVELLDKTFAQAQDVFRQAMK-SPSVVLHVLLPQNREQYE 297

  Fly   266 ---IERLK---KDEQLARAEIKVLQLANADLKKRDLLKSRDSSWSKEFPSGKELENSKELEKLRK 324
               |.:|.   .::..:|.:........|.||..:..:: :|...:|.||.::.::.:.....||
  Rat   298 KSVIGQLNIFGNNDSASRTKAPPPTRGKAGLKAVNPTRA-NSPEGEESPSPQQSKSPRVPRLGRK 361

  Fly   325 SLEKALSEVERSSQDAEEAKRVRDWAISQREKI---VQERDS---------VKTLCDKMRHERDK 377
            ....:||.: ......:.||:::.......|.:   |..|||         ||.:..|....:|.
  Rat   362 PSSPSLSPL-MGFGSKKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAVKDG 425

  Fly   378 AI--SDSLMAIRDSEKIKKQKDE------AQKKIDLLKEQMEQQERQNLDSNASGSRRSFRPSSY 434
            .:  .|.::.:...:...:.::|      :.|:.:.:...:.:||...|.....|....:..|..
  Rat   426 RLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETVSLVIARQEGSFLPRELKGEPDCYALSLE 490

  Fly   435 EGEDL-LEVELS---------------GYEHTSDLGIILDDSNKRKLVCGVTSSSPACGKLKIND 483
            ..|.| ||:.|:               ..|..:||||.:     :.::.|..:...  |:|::||
  Rat   491 SSEQLTLEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFI-----KSIIHGGAAFKD--GRLRMND 548

  Fly   484 VICKVN--------NLDCQSLSKRMV---------------------LDEIRACAPRS------- 512
            .:..||        |.:.....:|.:                     |:||..|...|
  Rat   549 QLIAVNGETLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRLERPLEEISECGALSRPCFENC 613

  Fly   513 --LLLVSRTRHSKR----HAYSVQLKTRD---------------RDCPH-GLQLDMGVFIAKIEQ 555
              .|..||...|..    ..||.|.|.:|               ...|| .|:..:..|......
  Rat   614 QEALSASRRNDSSLLYPCGTYSPQDKRKDLLLPSDGWAENEVPPSPPPHPSLEWGLEDFSHSSRV 678

  Fly   556 NSLAFYEPELDVGDRVL-------SIN---NKSMDSVQSIEEVMQLMNDPRSDGLNLFALKYVQD 610
            :|..:: |:..|..|::       |||   :||||.|.. |..:|.:.|.|||.
  Rat   679 DSTGYF-PDQHVNFRIVTPVGQPESINLKASKSMDLVPD-ESKVQSLADRRSDS----------- 730

  Fly   611 QLPPGM----TTSSAQTDSIDSMQHVSSAGGGGGSGPSSATKHPSRFAEFFFRKLKFSKP----- 666
               ||.    |....::.|::|:|                    :..||.....|.|.:|
  Rat   731 ---PGKDFGPTLGLKKSSSLESLQ--------------------TAVAEVRKNDLPFHRPRPHMV 772

  Fly   667 ---GTPED---NFEQEHDDAIAALDSVLSENSSEKSK---------------ENLFNRKKRTKKE 710
               |..|.   ..::.:|....|....||:.||....               :::.|:.|..||.
  Rat   773 RGRGCNESFRAAIDKSYDGPEEAEADGLSDKSSHSGHTALNCESAPQGNPELDDVENKAKNVKKT 837

  Fly   711 KEASKSMGTW------PRTNISHENPTGTMRGNEKKRALMSLFTAGPINVDK------------- 756
            ||..|..|..      .:....||:....|    |::...::...|....||
  Rat   838 KEKEKKKGKGKMKVKEKKQKEEHEDTERKM----KRKGFGAMLRFGKKKDDKVGKTEQKGTQKSG 898

  Fly   757 ---DDEL--MGE----VG-----VPEKQPAALI--------------QDQLPPPLPPQMSKPLAH 793
               ::||  |.|    :|     :.|||...|:              .|::.|..     ..:.|
  Rat   899 HPGEEELERMKEERERIGAKHQELREKQARGLVDYATVATGPVHDIDDDEMDPNY-----ARVNH 958

  Fly   794 IRGSNGGAIKTHPNRNSNPVSSGVSALFPPGPPN----GMPNTSYPTHPRHSLYGVTAEEINQKP 854
            .|         .|..::|...|       |.||.    |.|....|..|.| |.|:.| ::| ||
  Rat   959 FR---------EPCTSANVFRS-------PSPPRAGTLGYPRDGRPLSPDH-LEGLYA-KVN-KP 1004

  Fly   855 I-------QRAPLMGANARVKMPSQERYG---------------TRP--HSNHRLSLNITPSGDF 895
            .       ...|:.|...|::...:|.|.               |||  :..|.:| ...|.|..
  Rat  1005 YHPPALADSGRPMAGTTDRIQKLRKEYYQARREGFLLYEDEEGVTRPSDYDLHWVS-GKGPDGSA 1068

  Fly   896 YQPKTSGQQAQQQVMNASSTSAGFGVGSGSMVGG-TGPAAGEFPVRKQQVYDVFHPPPLPKNSSG 959
            :..:..|.:.|.     :|...|   ||...|.. |....|.:..|:...|    |.|
  Rat  1069 HNLRFEGMERQY-----ASLPRG---GSADPVDYLTASPRGRYNERELPYY----PGP------- 1114

  Fly   960 SNMFMPLHPTRGSHPPPVGQPPD--VVSLKSQNSIESILSAKSPAISEYGMYAKRHVPQAVRHVP 1022
                .|:|..|||:|    :|||  |..|:                  |..|
  Rat  1115 ----HPVHSPRGSYP----RPPDLRVTDLR------------------YPQY------------- 1140

  Fly  1023 KYPSDSESIGSGVHGGYGGFLQSNHMPGNRHTQLFPTFGPGGRGNRRSSPLTLPSPPPQQQL--- 1084
             ||..                     |.::|...|          |:..|   ||||..|::
  Rat  1141 -YPPP---------------------PAHQHKGPF----------RQDVP---PSPPQHQRVPVY 1170

  Fly  1085 QQLPAATAPHDSVGIPTDLDYHPHHHTQTNAM 1116
            |::..| .|..  |.|....|......|.|.|
  Rat  1171 QEMGRA-GPRG--GSPDQYPYRNQDPRQKNPM 1199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211	31/137 (23%)
		CENP-F_leu_zip	229..360	CDD:287450	27/149 (18%)
		DUF1090	<326..408	CDD:284007	16/101 (16%)
		PDZ_signaling	439..516	CDD:238492	24/130 (18%)
		PDZ_signaling	533..592	CDD:238492	19/84 (23%)
		PDZ_signaling	1290..1369	CDD:238492
		PDZ_signaling	1497..1576	CDD:238492
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
Pard3b	NP_001178737.1	DUF3534	1..143	CDD:288873
		PDZ_signaling	201..288	CDD:238492	15/54 (28%)
		PDZ	380..469	CDD:214570	13/88 (15%)
		PDZ_signaling	501..589	CDD:238492	15/94 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900