DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dlg5 and GUK1

DIOPT Version :9

Sequence 1:NP_609505.1 Gene:Dlg5 / 34573 FlyBaseID:FBgn0032363 Length:1916 Species:Drosophila melanogaster
Sequence 2:XP_005273161.1 Gene:GUK1 / 2987 HGNCID:4693 Length:263 Species:Homo sapiens


Alignment Length:224 Identity:45/224 - (20%)
Similarity:87/224 - (38%) Gaps:50/224 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly  1721 GGALSYQRVELLDSPIR----------RPVLIIGPL---SECLMVRLTIDFSNLFKLC------- 1765
            ||:   |....|.:|:.          |||::.||.   ...|:.||..:.|.:|...       
Human    47 GGS---QETFHLGAPVETTCLAGMSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRN 108

  Fly  1766 ----EVTAMD---CSQEAMEEGLKENIFVDYRR-RGNKFECTTVEAISNACKNDRRHCILDVSIS 1822
                |....|   .::|.|:..:....|:::.. .||.:..:.|..  .|.:...|.|:|||.:.
Human   109 PRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAV--QAVQAMNRICVLDVDLQ 171

  Fly  1823 AVERLQRLQIYPIVLLLRFKSAKQIRD-IRDFGTDKISAKAAKEMYERAMKLETDYKQYISAVIP 1886
            .|..::...:.||.:.::..|...:.. :|...|:     ..:.:.:|....:.|.:   |:..|
Human   172 GVRNIKATDLRPIYISVQPPSLHVLEQRLRQRNTE-----TEESLVKRLAAAQADME---SSKEP 228

  Fly  1887 GV--------SIKHMCTQIKDAVDKEQDK 1907
            |:        |:.....::|:|:.:|..|
Human   229 GLFDVVIINDSLDQAYAELKEALSEEIKK 257

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dlg5NP_609505.1 AAA_23 <165..333 CDD:290211
CENP-F_leu_zip 229..360 CDD:287450
DUF1090 <326..408 CDD:284007
PDZ_signaling 439..516 CDD:238492
PDZ_signaling 533..592 CDD:238492
PDZ_signaling 1290..1369 CDD:238492
PDZ_signaling 1497..1576 CDD:238492
SH3_DLG5 1594..1657 CDD:212794
Guanylate_kin 1737..1904 CDD:279019 38/203 (19%)
NK <1773..1905 CDD:302627 26/141 (18%)
GUK1XP_005273161.1 Guanylate_kin 69..254 CDD:279019 38/194 (20%)
guanyl_kin 71..253 CDD:213788 38/191 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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