DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and Lrguk

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	XP_017448017.1	Gene:	Lrguk / 296968	RGDID:	1308226	Length:	1271	Species:	Rattus norvegicus

Alignment Length:	1218	Identity:	236/1218 - (19%)
Similarity:	395/1218 - (32%)	Gaps:	391/1218 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 SCSEKLAELKKERNMVAVEREKYKKSYIELEKDRNYYRERGDENQKLKVLLSQESKNV---LSLT 235
            ||...|.||...:|.:.                 .::..:..:|.|.||..|....:.   ||..
  Rat   167 SCMPYLLELNASQNRLT-----------------TFFNFKPPQNLKQKVDFSSNQISEMYDLSAY 214

  Fly   236 EELNQLLSEKDNVLQEHQKMS-----DDLVLANKEIERLKKDEQLARAEIKVLQLAN------AD 289
            ..|.||:.: :|.::|...:.     ..|.||...|..:|   .|....||||.::|      ..
  Rat   215 HTLTQLILD-NNEIEEITGLEKCISLTHLSLAGNRITTIK---GLGTLPIKVLSVSNNQIETITG 275

  Fly   290 LKKRDLLKSRDSSWSKEFPSGKELENSKELE--KLRKSLEKALSEVERSSQDAEEAKRVRDWAIS 352
            |::...|::.|.| ..:..|...|||...||  .|..:..|.|||:|          .:.:..|.
  Rat   276 LEELKALQNLDLS-HNQISSLHGLENHDLLEVINLEDNKIKELSEIE----------YIENLPIL 329

  Fly   353 QREKIVQERDSVKTLCDKMRHERDKAISDSLMAIR----DSEKIK-KQKDEAQKKIDLLKEQMEQ 412
            :...::  |:.::|       :.:.......|.:|    |.:||| ::|..|..|.|...|.:..
  Rat   330 RVLNLL--RNPIQT-------KPEYWFFVIFMLLRLTELDQQKIKVEEKVYAVNKYDPPPEVVAA 385

  Fly   413 QERQ-NLDSNASGSRRSF---RPSSYEGEDLLEVELSGYEHTSDLGIILDDSNKRKLVCGVTSSS 473
            |:.. ::.::.|..:|.|   .||                        ||......::.|    .
  Rat   386 QDHMTHVVNSMSQPQRIFDSTLPS------------------------LDAPYPMLILTG----P 422

  Fly   474 PACGKLKINDVICKV---------------------NNLDCQSLSKRMVLDEIRACAPRSLLLVS 517
            .||||.::...:|:.                     :.:|...:|:. |.||:.:.....|
  Rat   423 EACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFVSQE-VFDEMLSMGKFIL---- 482

  Fly   518 RTRHSKRHAYSVQLKTRDRDCPHGLQLDMGVFIAKIEQNSLAFYEPE------LDVGDRVLSINN 576
             |.:...|.|.:...|.:.....||...:.:.:..|.....:::||.      :|.......:..
  Rat   483 -TFNYGNHNYGLNRDTVEGIARDGLASCIHMELEGIRSLKYSYFEPRYILVVPMDKEKYEGYLRR 546

  Fly   577 KSMDSVQSIEEVMQLMNDPRSDGLNLFALKYVQ-DQLPPGMTTSSAQTDSID------------- 627
            |.:.|...||..:..::            .||: ::..||...:....|.:|
  Rat   547 KGLFSRAEIEIAVSRVD------------LYVKVNRKFPGYFDAVINADDLDIAYQKLSELIREY 599

  Fly   628 -SMQHVSSAGGGGGSGPSSATKH----PSRFAEFFFRKLKFSKPGTPEDNF--EQEHDDAIAALD 685
             .:...:..|....:|.||:.|.    |:.......|..:....|...:.|  .|.|
  Rat   600 LGLTETAKKGLAPTAGASSSKKTVSGVPAHLVPSPRRLARLQADGQKTEAFLEVQPH-------- 656

  Fly   686 SVLSENSSEKSKENLFNRKKRTKKEKEASKSMGTWPR----------------TNISHENPTGTM 734
            :::.||.:....::....::....:||||.|....|:                .|:..:..|.|
  Rat   657 AMIPENQNPTLPQSQDLTEEGEAPKKEASPSHLDLPQQTQDISPKVKEEDGQPANLPPKITTET- 720

  Fly   735 RGNEKKRALMSLFTAGPINVDKDDELMGEVGVPEKQPAALIQDQLPPPLPPQMSKPLAHIRGSNG 799
            .|.|.: .:..:..||..:.....|       |.:.||.      .|||.||:.      :....
  Rat   721 EGPEDE-PVPPVLEAGQSSTMASQE-------PPQHPAP------APPLSPQLD------QDKES 765

  Fly   800 GAIKTHPN--------RNSNPVSSGVSALFPPGPPNGMPNTSYPTH-----PRH----------- 840
            |..|..||        :..:|.|.....:...|..:....:|..||     |.|
  Rat   766 GETKVTPNNPALSEPAQGPDPASVSPQRVQDEGAESANLASSSSTHNLPEDPSHAEIEKPTVGSQ 830

  Fly   841 -SLYGVTAEEINQKPIQRA--------PLMGANARVKMPSQERYGTRPHSNHRLSLNITPSGDFY 896
             ||    .||..:..:.||        |...::.:|:   ::.....|.|  ||:....|
  Rat   831 PSL----KEETPKAEVMRASTPYPEIPPPQDSSTKVR---EQPVALLPRS--RLAPTRLP----- 881

  Fly   897 QPKT----SGQQAQQQVMNASSTSAGFGVGSGSMVGGTGPAAGEFPVRKQQVYDVFHPPP--LPK 955
            ||:|    ..::...::::.|...|            .|.::.:.|          :|.|  ||.
  Rat   882 QPQTLAPLQSRRPTPKLLSPSREEA------------LGTSSEQTP----------NPSPRSLPT 924

  Fly   956 NSSGSNMFMPLHPTRGSHPPPVGQPPDVVSLKSQNSIESILSAKSPAISEYGMYAKRHVP---QA 1017
            .....:...|:.|.:..  ||....|..|....|..:|.....|.|.||.         |   ||
  Rat   925 QDGDPSKLPPISPPQSK--PPQNPSPHAVHSPQQAQVEKGSEVKLPLISP---------PVQEQA 978

  Fly  1018 VRHVPKYPSDSE-------SIGSGVHGGYGGFLQSNHMPGNRHTQLFPTFGPG--------GRGN 1067
            ::|.||.|.:.|       :|.:.        ....|:|.|  |:..|...|.        ||.:
  Rat   979 LQHTPKPPQEEEAPTVRLPNIPAP--------STEPHLPQN--TEPRPASKPARERKTPKVGRAS 1033

  Fly  1068 RRSSPLTLPSPPPQQQL------------QQLPAATAPHDSVGIPTDLDYHPHHHTQTNAMPHPH 1120
            .: ..|.|.:.|..|:|            |:..|...||     |..:   |..::||...|..|
  Rat  1034 SK-KVLDLQATPHSQELTKQKGARKKTLTQRETAKELPH-----PKKM---PIGNSQTAQQPESH 1089

  Fly  1121 PHP----HAPYLDY----GHGLGIGPYMGVGGGVSGVGGAIYEGGTFP-----------RKKDNQ 1166
            ..|    .:..||:    ||                         |.|           ||..|.
  Rat  1090 SRPTPRNESDALDFRSSPGH-------------------------TEPVSADPQNREKNRKAHNP 1129

  Fly  1167 RLRIPSNPSVASKSSSMVKNSSGSIDHHYVTSTGPVSGGSMSASSSDR 1214
            |.:..:||:....|.|...:.:|.:      |.| ::.|:.:|.|.|:
  Rat  1130 RKKAQTNPTPKDASQSTRTSPNGEM------SEG-LTQGNETALSEDQ 1170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211	43/174 (25%)
		CENP-F_leu_zip	229..360	CDD:287450	35/146 (24%)
		DUF1090	<326..408	CDD:284007	18/86 (21%)
		PDZ_signaling	439..516	CDD:238492	14/97 (14%)
		PDZ_signaling	533..592	CDD:238492	11/64 (17%)
		PDZ_signaling	1290..1369	CDD:238492
		PDZ_signaling	1497..1576	CDD:238492
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
Lrguk	XP_017448017.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900