DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and Dlg4

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_062567.1	Gene:	Dlg4 / 29495	RGDID:	68424	Length:	724	Species:	Rattus norvegicus

Alignment Length:	784	Identity:	182/784 - (23%)
Similarity:	306/784 - (39%)	Gaps:	240/784 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1234 GGNGTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGS--GKRNSNVPADFLCPGDLRRVT-- 1294
            |.:|.|.||    .||..:......|.:.:..:..||..:  |:...|....|:...|:|.||
  Rat    71 GNSGLGFSI----AGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHS 131

  Fly  1295 -------------------------------IDKRDKSLGITIQCNNNGG----------GIFVS 1318
                                           :.|..|.||.:|.    ||          .|:|:
  Rat   132 AAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIA----GGVGNQHIPGDNSIYVT 192

  Fly  1319 TVADKSTAMRAG-LQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLV----------QYNP 1372
            .:.:...|.:.| ||:||::|.|..:.:.....|.|...|:...|...:.|          .|.|
  Rat   193 KIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP 257

  Fly  1373 EKFPSIEYEGAHNLEPESPINHS---GSPTPRNSPRPPARNSLFPLPMQPQAPSTRPGSRAPLSH 1434
               |.|....:.:|:.|  |:||   |:.              :|..|.|    |.|...:|::
  Rat   258 ---PDITTSYSQHLDNE--ISHSSYLGTD--------------YPTAMTP----TSPRRYSPVA- 298

  Fly  1435 QSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSLPPPPASVPAETLRY 1499
                           .|:...:|:|                   .||                |.
  Rat   299 ---------------KDLLGEEDIP-------------------REP----------------RR 313

  Fly  1500 VTLHMDKSKNLGIKLFGG-NKVGIYVHDVAVGSPSDHAG-IRKGDQILEYNGVDLSGVTAEQAAN 1562
            :.:|.. |..||..:.|| :..||::..:..|.|:|.:| :|||||||..|||||...:.||||.
  Rat   314 IVIHRG-STGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 377

  Fly  1563 EISKLTDTVTMLVQ----------NKLHTLKQ-------------IKDEPGDSFYIRV--GFDRT 1602
            .:.....|||::.|          .|:|.|::             ::..|...||||.  .:|:|
  Rat   378 ALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKT 442

  Fly  1603 ---GELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRKECGIIPSQMKVEEELRSGEV 1664
               |.|:: .|.|...:||:|   :..|....|:|.::.:.....:.|.|||:.:||
  Rat   443 KDCGFLSQ-ALSFRFGDVLHV---IDAGDEEWWQARRVHSDSETDDIGFIPSKRRVE-------- 495

  Fly  1665 VDCDTGTARRGSTSARRSFFRRK-KNQRSSSRDSTEIASFSNTQLSFFPDLGLLNDDGGALSYQR 1728
                           ||.:.|.| |:..|||                    |....:...|||:.
  Rat   496 ---------------RREWSRLKAKDWGSSS--------------------GSQGREDSVLSYET 525

  Fly  1729 VELLDSPIRRPVLIIGPLSECLMVRLTIDFSNLFKLC-----------EVTAMD----CSQEAME 1778
            |..::....||::|:||..:.....|..:|.:.|..|           |:...|    .|:|.||
  Rat   526 VTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKME 590

  Fly  1779 EGLKENIFVDYRRRGNKFECTTVEAISNACKNDRRHCILDVSISAVERLQRLQIYPIVLLLRFKS 1843
            :.::.:.|::..:..:....|:|:::....:.. :|||||||.:||.|||...::||.:.:|.:|
  Rat   591 KDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQG-KHCILDVSANAVRRLQAAHLHPIAIFIRPRS 654

  Fly  1844 AKQIRDIRDFGTDKISAKAAKEMYERAMKLETDYKQYISAVIPGVSIKHMCTQIKDAVDKEQDKL 1908
            .:.:.:|    ..:|:.:.|::.::||.|||.::.:..||::.|.|.:.:..::|..::......
  Rat   655 LENVLEI----NKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPY 715

  Fly  1909 LWVP 1912
            :|||
  Rat   716 IWVP 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	25/132 (19%)
		PDZ_signaling	1497..1576	CDD:238492	32/80 (40%)
		SH3_DLG5	1594..1657	CDD:212794	20/67 (30%)
		Guanylate_kin	1737..1904	CDD:279019	47/181 (26%)
		NK	<1773..1905	CDD:302627	36/131 (27%)
Dlg4	NP_062567.1	MAGUK_N_PEST	10..64	CDD:287565
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..35
		PDZ	65..149	CDD:278991	17/81 (21%)
		PDZ	160..244	CDD:278991	21/87 (24%)
		PDZ_assoc	245..312	CDD:287558	21/140 (15%)
		PDZ	310..394	CDD:214570	35/100 (35%)
		SH3_DLG4	430..495	CDD:212963	20/68 (29%)
		Guanylate_kin	533..711	CDD:279019	47/182 (26%)
		GuKc	544..710	CDD:214504	42/170 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810