DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and Pdzd7

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_001099832.2	Gene:	Pdzd7 / 293996	RGDID:	1309882	Length:	1031	Species:	Rattus norvegicus

Alignment Length:	1258	Identity:	247/1258 - (19%)
Similarity:	393/1258 - (31%)	Gaps:	456/1258 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   362 DSVKTLCDKMRHERDKAISDSLMAIRDSEKIKKQKDEAQKKIDLLKEQMEQQERQN-------LD 419
            ||..|....:..::.:.::.....||.|..:        .::.|:...:|....::       ::
  Rat    34 DSASTATRYLLRKQQRLLNGPSRGIRASSPM--------GRVILINSPIEANSDESDIIHAVCVE 90

  Fly   420 SNASGSRRSFRPSSYEGEDLLEVELSGYEHTSDLGIILDDSNKRKLVCGVTSSSPACGKLKINDV 484
            .:.|| |..|   |..|         |.||  .|||.:.     |:..|  ||:...| |.:.|.
  Rat    91 KSPSG-RLGF---SVRG---------GSEH--GLGIFVS-----KVEEG--SSAERAG-LCVGDK 132

  Fly   485 ICKVNNLDCQS-----------------------------------------LSKRMVLDEIRAC 508
            |.:||.|..:|                                         :::|:|:::..:.
  Rat   133 ITEVNGLSLESTTMGSAVRLLTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKCSST 197

  Fly   509 APRSLLLVSRTRHSKR--HAYSVQLKTRDRDC-----PHGLQLDMGVFIAKIEQNSLAFYEPELD 566
            ...|    |.....:|  |.|:    |.|..|     ..|.:..:|::::|::...|| .|..:.
  Rat   198 PSDS----SSEDGVRRIVHLYT----TSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLA-EENGIK 253

  Fly   567 VGDRVLSINNKSMDSV---QSIEE-------VMQLMNDPRSDGLNLFALKY---------VQDQL 612
            |||:||:.|....|.:   |::|.       ::.:....|.........:|         |..||
  Rat   254 VGDQVLAANGVRFDDISHSQAVEVLKGQTHIMLTIKETGRYPAYKEMVSEYCWLDRLSNGVLQQL 318

  Fly   613 PPGMTTSSAQTDSIDSMQHVSSAGGGGGS----------GPSSATKHPSRFAEFFFRKLKFSKPG 667
            .|...:||    |:.|  :.|||....||          ||...|.....:             |
  Rat   319 SPASESSS----SVSS--YASSAPCSSGSLPSDRMDVCLGPEDPTSQGPGW-------------G 364

  Fly   668 TPEDNFEQE--------------------HDDAIAA--------LDSVLSEN------------- 691
            ..:...:.|                    .|.||.:        |||.|||:
  Rat   365 RADTAMQTEPDMGGSRVETWCSVRPTVILRDTAIRSDGPSSTRHLDSALSESPKTALLLALSRPR 429

  Fly   692 ---SSEKSKENLFNRKKRTKKEKEASKSMGTWPRTNISHENPTGTMRGNEKKRALMSLFTAGPIN 753
               :..:|...|:..||:.||||..|                :|.....::.:.||:||..|
  Rat   430 PPITRSQSHLTLWEEKKQRKKEKSGS----------------SGEKGALQRSKTLMNLFFKG--- 475

  Fly   754 VDKDDELMGEVGVPE---KQPAALIQDQLPPPLPPQMSKPLAHIRGSNGGAIKTHPNRNSNPVSS 815
                    |..|.|.   .:.|..:..:.|..:.|::....|   ||.|...|....|.......
  Rat   476 --------GRQGRPAGDGHREAWTLDSRSPTKVRPRLDLEKA---GSVGPVQKFVTWRLRRDRER 529

  Fly   816 GVSALFP-PGPPNGMPNTSYPTHPRHSLYGVTAEEINQKPIQRAPLMGANARVKMPSQERYGTRP 879
            |.:.|.. .|.|:|.              |...:|..|....|.||:...||..:...|......
  Rat   530 GRALLSARSGSPSGQ--------------GPNVDEQMQAWESRRPLIQDLARRLLTDDEVLAVTR 580

  Fly   880 HSNHRLSLNITPSG--DFYQPKTSGQQAQQQVM---NASSTSAGFGVGS-GSMVGGTGPAAGEFP 938
            |    .|..:...|  |..:|..:......:::   :..|..|...:|. .|||         .|
  Rat   581 H----CSRYVHEGGVEDLVRPLLAILDRPAKLLLLRDIRSVVAPTDLGRFDSMV---------MP 632

  Fly   939 VRKQQVYDVFHPPPLPKNSSGSNMFMPLHPTRGSHPPPVGQPPDVVSLKSQNSIESILSAKSPAI 1003
            | :.:.::.     |...:.|.:   .|.|||...||
  Rat   633 V-EMEAFEA-----LKSRAVGPS---ALRPTRQDTPP---------------------------- 660

  Fly  1004 SEYGMYAKRHVPQAVRHVPKYPSDSESIGSGVHGGYGGFLQSNHMPGNRHTQLFPTFGPGGRGNR 1068
                   |||:   :..||    ||.          |||..   :|.|..::     ...|....
  Rat   661 -------KRHL---ITPVP----DSR----------GGFYL---LPVNSCSE-----DEDGEIRE 693

  Fly  1069 RSSPLTLPSPPPQQQLQQLPAATAPHDSVGIP--TDLDYHPHHHTQTNAMPHPHPHPHAPYLDYG 1131
            |...|.:..           .|:|||.. |||  .|:........:....|.|.|.|.||.....
  Rat   694 RLGGLKVSL-----------GASAPHHK-GIPPLQDVPVDAFSLRRGACAPPPQPPPVAPRPPRP 746

  Fly  1132 HGLGIGPYMGVGGGVSGVGGAIYEGGTFPRKKDNQRLRIPSNPSVASKSSSMVKNSSGSIDHHYV 1196
            :.|...|                     |.::|.|:.:..:.....|:|.|..::.|||......
  Rat   747 NWLLTEP---------------------PSREDTQQNQNQTPGQSCSRSRSHSRSRSGSRSRSRS 790

  Fly  1197 TSTGPVSGGSMSASSSDRAPMSLMSSSIHNSYGANIAGG----------------NGTGSSIGVG 1245
            ...|..:|...|.|.   ||::..:|          |.|                :|..:.:||
  Rat   791 QGRGKSAGCRRSPSP---APITTATS----------ANGRYHRPRKARPLLPRPLDGQVAKVGV- 841

  Fly  1246 GGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRVTIDKRDKSLGITIQCNN 1310
                    |..|:.....:......|.:            ..|:||.||:.|..:||||:|
  Rat   842 --------RQEPLENGIDQTAEDEAGNA------------TTGELRTVTLSKMKQSLGISI---- 882

  Fly  1311 NGG------------GIFVSTVADKSTAMRAGLQVGDQLLEVCGINMRAATQEIAANVLR----- 1358
            :||            .||....|....|::||.    :|:.|.|.::...|.:.|.:.:|
  Rat   883 SGGIESKVQPMVKIEKIFPGGAAFLCRALQAGF----ELVAVDGESLEQVTHQRAVDTIRRAYRN 943

  Fly  1359 QCGDSFTMLVQY-NPEKFP------SIEYEG-------AHNLEPESPINHSGSPTPRNSPR---- 1405
            :..:...::|:. .|...|      :|:.:|       ||....::||.....||.....|
  Rat   944 KAREPMELVVRVPGPGLLPLSSNLRAIKGQGLAADSSSAHGPIEDTPILTQLPPTEARQLRHALS 1008

  Fly  1406 -----PPARNSLFPLPMQPQAPS 1423
                 |.:...|||:...|..||
  Rat  1009 SVQKVPQSTPKLFPIHKDPHNPS 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007	7/45 (16%)
		PDZ_signaling	439..516	CDD:238492	21/117 (18%)
		PDZ_signaling	533..592	CDD:238492	18/73 (25%)
		PDZ_signaling	1290..1369	CDD:238492	24/95 (25%)
		PDZ_signaling	1497..1576	CDD:238492
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
Pdzd7	NP_001099832.2	PDZ_signaling	84..164	CDD:238492	24/102 (24%)
		PDZ_signaling	209..289	CDD:238492	21/84 (25%)
		HN_PDZD7_like	555..632	CDD:259824	17/89 (19%)
		PDZ_signaling	866..954	CDD:238492	24/95 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810