DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dlg5 and Mpdz

DIOPT Version :9

Sequence 1:NP_609505.1 Gene:Dlg5 / 34573 FlyBaseID:FBgn0032363 Length:1916 Species:Drosophila melanogaster
Sequence 2:XP_006238402.1 Gene:Mpdz / 29365 RGDID:3105 Length:2068 Species:Rattus norvegicus


Alignment Length:1841 Identity:352/1841 - (19%)
Similarity:592/1841 - (32%) Gaps:646/1841 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   179 LAELKKERNMVAVEREKYKKSYIELEKDRNYYRERGD--ENQKL----KVLLSQESKNVLSLTEE 237
            |..:.|.|.:.|.||.:.|            .:||||  ...||    .||.|.....:|||...
  Rat     2 LETIDKNRALQAAERLQSK------------LKERGDVANEDKLSLLKSVLQSPLFSQILSLQTS 54

  Fly   238 LNQLLSEKDNVLQEHQKMSDDLVLANKEIERLKKDEQLARAEIKVLQLANAD------------- 289
            |.||   ||.|                              .:..|..||||             
  Rat    55 LQQL---KDQV------------------------------NVATLATANADHAHTPQFSSAIIS 86

  Fly   290 -LKKRDLLKSRDSSWSKEFPSGKELE---------------NSKELEKLRKSLEK---------- 328
             |:...||.|         ||...||               ..:||::|.||:.:          
  Rat    87 NLQSESLLLS---------PSNGNLEAISGPGAPPAMDGKPACEELDQLIKSMAQGRHVEIFELL 142

  Fly   329 -------ALSEVERSSQDAEE----AKRVRDWAISQREKIVQERDSV-----KTLCDKMRHERDK 377
                   ..|.|...|::..|    .:.:::.:::.|:..::|.|.:     :.|...:.|::..
  Rat   143 KPPCGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQVLDQTITHQQAI 207

  Fly   378 AISDSLMAIRDSEKIKKQKDEAQKKIDLLKEQMEQQERQNLDSNASGSRRSFRPSSYEGEDLLEV 442
            :|            ::|.||..|..|          .|.:| .:.|..|.|..||:..... ...
  Rat   208 SI------------LQKAKDTIQLVI----------ARGSL-PHISSPRISRSPSAASTVS-AHS 248

  Fly   443 ELSGYEHTSDLGIILDDSN---------------KRKLVCGVTSSSPACGKLKINDVICKVNNLD 492
            ..:.::|...:.::.|.|.               |..|..||....   |:|...|.|.|:.:.|
  Rat   249 NPTHWQHVETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQH---GRLCSGDHILKIGDTD 310

  Fly   493 CQSLSKRMVLDEIRACAPRSLLLVSR-------------------------------TRHSKRHA 526
            ...:|...|...:|.|..|..|:::|                               .::.:...
  Rat   311 LAGMSSEQVAQVLRQCGNRVKLMIARGAVEETPAPSSLGITLSSSTSTSEMRVDASTQKNEESET 375

  Fly   527 YSVQLKTRDRDCPHGLQLDM------------GVFIAKIEQNSLAFYEPELDVGDRVLSI---NN 576
            :.|:| |::   ..||.:.:            |:|:..|.::|....:..:.:||:::::   |.
  Rat   376 FDVEL-TKN---VQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVELDGRIQIGDQIVAVDGTNL 436

  Fly   577 KSMDSVQSIEEV--------MQLM-------------NDPRSDGLNLFALKYVQDQ--------- 611
            :...:.|::|.:        :.||             .|...| ::|.|..|.:|:         
  Rat   437 QGFTNQQAVEVLRHTGQTVRLTLMRKGASQEAEITSREDTAKD-VDLPAENYEKDEESLSLKRST 500

  Fly   612 --LP------PGMTTSSAQTDSIDS-------------------MQHVSSAGGGGGSGPS-SATK 648
              ||      |.::|...:|:.:..                   :.|||......|.|.| .|| 
  Rat   501 SILPIEEEGYPLLSTELEETEDVQQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEAT- 564

  Fly   649 HPSRFAEFFFRKLKFSKPGTPEDNFEQEHDDAIAALDSVLSENSSEKSKEN---LFNRKKRTKKE 710
                ....|.|.:      .||.  ...|...:.:.|.:|..|......||   :.|..|....:
  Rat   565 ----VGHHFIRSV------LPEG--PVGHSGKLFSGDELLEVNGINLLGENHQDVVNILKELPID 617

  Fly   711 KEASKSMGTWPRTNISH------------ENP---TGTMRGNEKKRALMSLFTAGPI----NVDK 756
            ........|.|.|.:|.            |.|   .|...|:.:        |..|:    :||:
  Rat   618 VTMVCCRRTVPPTALSEVDSLDIHDLELTEKPHIDLGEFIGSSE--------TEDPMLAMSDVDQ 674

  Fly   757 DDE------LMGEVGVP----EKQPAAL------IQDQLPPPLPPQMSKPLAHIRGSNGGAI--- 802
            :.|      .|.|.|:.    ||....|      .||.:.|      :..:..||....|.|   
  Rat   675 NAEEIQTPLAMWEAGIQAIELEKGSRGLGFSILDYQDPIDP------ANTVIVIRSLVPGGIAEK 733

  Fly   803 --KTHP----------NRNSNPVSSGVSALFPPGPPNGMPNTS----YPTHPRHSLYGVTAEE-- 849
              :..|          |..::.:...|.||  .|.|:||....    .|..|....  |:|:|  
  Rat   734 DGRLFPGDRLMFVNDINLENSTLEEAVEAL--KGAPSGMVRIGVAKPLPLSPEEGY--VSAKEDT 794

  Fly   850 ------------INQKPIQRAPLMGANARVKMPSQERYGTRPHSNHRLSLNITPSGDFYQPKTSG 902
                        ::.|.:.||.|    |.:..|..|..     :..|.....:|..|      |.
  Rat   795 FLCSPHTCKEMGLSDKALFRADL----ALIDTPDAESV-----AESRFESQFSPDND------SV 844

  Fly   903 QQAQQQVMNASSTSAGFGVGSGSMVGGTGPAAGEFPVRKQQVYDVFHPPPLPKN-SSGSNMFMPL 966
            ...|..|::....:...|:..|..:                      |...||: ::.|::.:.|
  Rat   845 YSTQASVLSLHDGACSDGMNYGPSL----------------------PSSPPKDVTNSSDLVLGL 887

  Fly   967 HPTRGSHPPPVGQPPDVVSLKSQNSIESILSAKSPAISEYGMYAKRHVPQAVRHVPKYPSDSESI 1031
            |.:             :..|.:||.::.                        :|....|:|....
  Rat   888 HLS-------------LEELYTQNLLQR------------------------QHAGSPPTDMSPA 915

  Fly  1032 GSGVHGGYGGFLQSNHMPGNRHTQLF---------PTFGPGGRGNRRSSPLTLPSPPPQQQLQQL 1087
            .:      .||..|::.|.|...|.:         |:..|.|......:| .||:..|:...:| 
  Rat   916 AT------SGFTVSDYTPANAVEQKYECANTVAWTPSQLPSGLSTTELAP-ALPAVAPKYLTEQ- 972

  Fly  1088 PAATAPHDSVGIPTDLDYHPHHHTQTNAMPHPHPHPHAPYLDYGHGLGIGPYMGVGGGVSGVG-- 1150
            .:..:..:||.:.: :.......|.|.|..             ...||    |.|.....|:|  
  Rat   973 SSLVSDAESVTLQS-MSQEAFERTVTIAKG-------------SSSLG----MTVSANKDGLGVI 1019

  Fly  1151 -GAIYEGGTFPRKKDNQRLRI-PSNPSVASKSSSMVKNSSGSIDHHYVTSTGPVSGGSMSASSSD 1213
             .:|..||...|   :.|:.: ....|:..:|:..:.|:.........:..||....| :|.:.|
  Rat  1020 VRSIIHGGAISR---DGRIAVGDCILSINEESTISLTNAQARAMLRRHSLIGPDIKFS-AAPADD 1080

  Fly  1214 RAPMSLMSSSIHNSYGANIAGGNGTGSSIGVGGGGGG-------GSGRGSPMPQVHVEVLSHGGG 1271
            |||..:::         .:...:.....:..|...||       .|..|..:|:     |.....
  Rat  1081 RAPFYVIT---------YVPAEHLEEFRVSFGQQAGGIMALDIFSSYTGRDIPE-----LPEREE 1131

  Fly  1272 GSGKRNSNVPADFLCPGDLRRVTIDKR-DKSLGITIQCNNNGG----------GIFVSTVADKST 1325
            |.|:.:....|.:......|||.:.:. .|||||:|......|          |||:..|.:.|.
  Rat  1132 GEGEESELQNAAYSSWSQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSP 1196

  Fly  1326 AMRAG-LQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLVQYNPEKFPSIEYEGAHNLEPE 1389
            |.:.| |:.||:::||.|:::|.|:.|.|...:|:.|.....:||                    
  Rat  1197 AGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGSPVVFMVQ-------------------- 1241

  Fly  1390 SPINHSGSPTPRNSPRPPARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDISS 1454
            |.:|.     ||.||.|...:||:|   :....||.|               |.:||:..||.:.
  Rat  1242 SIVNR-----PRKSPLPSLPHSLYP---KCSFSSTNP---------------FAESLQLTSDKAP 1283

  Fly  1455 SQDMPSSAATTTTTTASATSTVYDEEPKPSLPPPPASVPAETLRYVTLHMDKSKNLG-----IKL 1514
            ||....|...|..:..|::.:|:.|.......|...:|..:.        ||....|     |:.
  Rat  1284 SQSESESEKATLCSVPSSSPSVFSEMSSDYAQPSATTVAEDE--------DKEDEFGYSWKNIQE 1340

  Fly  1515 FGGNKVG-IYVHDVAVGSPSDHAGIRKGDQILEYNGVDLSGVTAEQAANEISKLTDTVTMLVQNK 1578
            ..|...| :::.::..|    |:|:          |:.|:|                        
  Rat  1341 RYGTLTGQLHMIELEKG----HSGL----------GLSLAG------------------------ 1367

  Fly  1579 LHTLKQIKDEPGDSFYIRVGFDRTGELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHR 1643
                  .||....|.:| ||.|.||....|....:.||:|.::..:..|            ..|:
  Rat  1368 ------NKDRTRMSVFI-VGIDPTGAAGRDGRLQIADELLEINGQILYG------------RSHQ 1413

  Fly  1644 KECGII---PSQMKVEEELRSGEVVD----CDTGTARRGSTSARRSFFRRKKNQRSSSRDSTEIA 1701
            ....||   ||::|: ..:|:.:.|:    |....|....:::.....:..:...::|..:.:::
  Rat  1414 NASSIIKCAPSKVKI-IFIRNADAVNQMAVCPGSAADPLPSTSESPQNKEVEPSITTSASAVDLS 1477

  Fly  1702 SFSNTQLSFFPDLGLLNDDGG 1722
            |.:|..     .|.|..|.||
  Rat  1478 SLTNVY-----HLELPKDQGG 1493

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dlg5NP_609505.1 AAA_23 <165..333 CDD:290211 44/205 (21%)
CENP-F_leu_zip 229..360 CDD:287450 32/180 (18%)
DUF1090 <326..408 CDD:284007 15/107 (14%)
PDZ_signaling 439..516 CDD:238492 19/91 (21%)
PDZ_signaling 533..592 CDD:238492 12/81 (15%)
PDZ_signaling 1290..1369 CDD:238492 29/90 (32%)
PDZ_signaling 1497..1576 CDD:238492 12/84 (14%)
SH3_DLG5 1594..1657 CDD:212794 17/65 (26%)
Guanylate_kin 1737..1904 CDD:279019
NK <1773..1905 CDD:302627
MpdzXP_006238402.1 L27_2 6..63 CDD:117611 24/101 (24%)
PDZ_signaling 140..222 CDD:238492 15/103 (15%)
PDZ_signaling 256..335 CDD:238492 18/81 (22%)
PDZ 374..463 CDD:214570 16/92 (17%)
PDZ_signaling 552..621 CDD:238492 17/81 (21%)
PDZ_signaling 693..776 CDD:238492 19/90 (21%)
PDZ_signaling 993..1063 CDD:238492 17/89 (19%)
PDZ_signaling 1150..1241 CDD:238492 29/90 (32%)
PDZ 1348..1433 CDD:214570 26/142 (18%)
PDZ_signaling 1482..1561 CDD:238492 5/17 (29%)
MPDZ_u10 1563..1624 CDD:293272
PDZ 1625..1709 CDD:214570
PDZ_signaling 1721..1801 CDD:238492
PDZ_signaling 1858..1943 CDD:238492
PDZ_signaling 1984..2067 CDD:238492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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