DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlg5 and caska

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	XP_017213110.1	Gene:	caska / 259195	ZFINID:	ZDB-GENE-020802-4	Length:	965	Species:	Danio rerio

Alignment Length:	720	Identity:	135/720 - (18%)
Similarity:	229/720 - (31%)	Gaps:	232/720 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1326 AMRAGLQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLVQYNPEKFPSIEYEGAHN----- 1385
            |.||..||.|.|.|:              :.|..|.:.               :.:..|:
Zfish   344 AERAVSQVLDSLEEI--------------HALTDCSEK---------------DLDFLHSVFQDH 379

  Fly  1386 -----LEPESPINHSGSPTPRNSPRPPARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDS 1445
                 |:....||...||..||    |:.:::    .:.:..||..||.|.|.|.....:..:..
Zfish   380 HLHTLLDLYDKINTKSSPQIRN----PSSDAV----QRAKETSTEDGSSAALKHLEYVLEEISCY 436

  Fly  1446 LEN--QSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSLPPP---------PASVPAE---- 1495
            .||  ..::......|...|...|....| ..||.::.....|||         |.|...:
Zfish   437 PENTDAKELRRILTQPHFMALLQTHDVVA-HEVYSDDAMRVTPPPTSPYLNGDSPESTNGDMDIE 500

  Fly  1496 ---TLRYVTLHMDKSKNLGIKLFGGNKVGIYVHDVAVGSPSDHAG-IRKGDQILEYNGVDLSGVT 1556
               .:|.|....:..:.:||.|...:.....|..:..|......| :..||:|.|.||:.::..|
Zfish   501 NVTRVRLVQFQKNTDEPMGITLKMNDLNHCIVARIMHGGMIHRQGTLHIGDEIREINGISVANQT 565

  Fly  1557 AEQAANEISKLTDTVTMLVQNKLHTLKQ------------------------------------- 1584
            .||....:.::..::|..:.....|.:.
Zfish   566 VEQLQKMLREMRGSITFKIVPSYRTQQSSCEKESPSTSRQSPANGHSSINSSILDLPSTIQPKGR 630

  Fly  1585 ------IKDEPGDSFYIRVGFD------------------RTGE----LNEDDLRFVKDEVLYVD 1621
                  |||:.....|:|..|:                  |.|:    :|:||..:.:.:   ::
Zfish   631 QISRPPIKDKFSIKIYVRAQFEYDPVKDDLIPCKEAGIRFRVGDIIQIINKDDHNWWQGK---LE 692

  Fly  1622 NTVFNGTFGLWRAWKLDAMGHRKECGIIPSQMKVEEELRSGEVVDCDTGTARRGSTSARRSFFRR 1686
            ||. |||                 .|:|||     .||:...|. |......:....|..::|.:
Zfish   693 NTK-NGT-----------------AGLIPS-----PELQEWRVA-CIAMEKTKQEQQASCTWFGK 733

  Fly  1687 KKNQRSSSRDSTEIASFSNTQLSFFPDLGLLNDDGGALSYQRVELLDSPIRRPVLIIGP------ 1745
            ||.|......:...|.|....|               ::|:.|..|.:..|:.::::|.
Zfish   734 KKKQYKDKYLAKHNAVFDQLDL---------------VTYEEVVKLPAFKRKTLVLLGAHGVGRR 783

  Fly  1746 -LSECLMVRLTIDFS------------------NLFKLCEVTAMDCSQEAMEEGLKENIFVDYRR 1791
             :...|:.:....|:                  |.|.:        |.:.|.:.:..|.:::|..
Zfish   784 HIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYFFV--------SHDQMMQDISNNDYLEYGS 840

  Fly  1792 RGNKFECTTVEAISNACKNDRRH-----CILDVSISAVERLQRLQIYPIVLLLRFKSAKQIRDIR 1851
            ..:....|.:|.|.      :.|     .||||...|::.|:..:..|.|:   |.:|..|..
Zfish   841 HEDAMYGTRLETIR------KIHEQGLIAILDVEPQALKVLRTAEFAPYVV---FIAAPTITP-- 894

  Fly  1852 DFGTDKI---SAKAAKEMYERAMK----LETDYKQYISAVIPGVSIKHMCTQIKDAVDKEQDKLL 1909
              |.:::   ..|...|..:|..|    |:..|..|....|....|......:::|:|.......
Zfish   895 --GMNELPRWCRKLPDESLQRLQKESEILQKTYAHYFDQTIINNEIDETIRLLEEAIDMVCSTAQ 957

  Fly  1910 WVPVS 1914
            |||||
Zfish   958 WVPVS 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	10/42 (24%)
		PDZ_signaling	1497..1576	CDD:238492	18/79 (23%)
		SH3_DLG5	1594..1657	CDD:212794	17/84 (20%)
		Guanylate_kin	1737..1904	CDD:279019	37/203 (18%)
		NK	<1773..1905	CDD:302627	31/143 (22%)
caska	XP_017213110.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810