DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and X11L

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	893	Identity:	174/893 - (19%)
Similarity:	263/893 - (29%)	Gaps:	289/893 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   807 NRNSNPVSSGVSALFPPGPPNGMPNTSYPTHPRHSLYGVTAEEINQKPIQRAPLMGANARVKMPS 871
            |.||...||..|.:.||             |.:.: :|..|::......|:          :...
  Fly     2 NSNSCSDSSNESMVNPP-------------HIQMN-FGQQAQQQQSHQHQQ----------QQQQ 42

  Fly   872 QERY----GTRPHSNHRLSLNITPSGD-FYQPKTSGQQAQQQVMNASSTSAGFGVGSGSMVGGTG 931
            ||||    .||       |.|:||:.. ...|..:|:.:...:...|.:..|. .||||.....|
  Fly    43 QERYVWEMRTR-------SPNVTPASTVLNSPDLNGELSYVPLQGLSPSGGGV-QGSGSYGSNAG 99

  Fly   932 PAAGEFPVRKQQVYDVFHPPPLPKNSSGSNMFMPLHPTRGSHPPPV---GQPPDVVSLKSQ---- 989
            ..:|.:..::.|::.:     ....|.||..     .||...|..:   |.|.||.....|
  Fly   100 RDSGSYYYQRPQLHQI-----RLGRSPGSQF-----ETRDVLPQGLASPGSPTDVGKADGQCLRD 154

  Fly   990 -----------NSIESILSAKSPAISEYGMYAKRHVPQAVRHVPKYPSDSESIGSGVHGGYGGFL 1043
                       |.:....|.:.|..:|..:...:.:.|.  .:.:|.......||
  Fly   155 GEIVVFDDIDTNWMNKASSGQRPGSNEDVLKVTKMIGQL--PIAEYEGSPRRFGS---------- 207

  Fly  1044 QSNHMPGNRHTQLFPTFGPGGRGNRRSSPLTLP---SPPPQQQLQQLPAATAPHDSVGIPTDLDY 1105
            |.|       |......||      |..|...|   ||..........||.|   |||...||..
  Fly   208 QPN-------TNTITMGGP------RKRPPGFPQRVSPTTSVANNATAAAKA---SVGNLIDLVD 256

  Fly  1106 HPHHHTQTNAMPHPHPHPHAPYLDYGHGLGIGPYMGVGGGVSGVGGAIYEGGTFPRKKDNQRLRI 1170
            |....:.|       .....|..||                      :||   |...:.......
  Fly   257 HEEERSGT-------LREKTPTFDY----------------------LYE---FSETRKVLEEFF 289

  Fly  1171 PSNPSVASKSSSMVKNSSGSIDHHYVTSTGPVSGGSMSASSSDRAPMSLMSSSIHNSYGANIAGG 1235
            .:||.                |....|.....||..:::|.....|
  Fly   290 KANPE----------------DEKRYTDYTTESGDDVASSQPQEYP------------------- 319

  Fly  1236 NGTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLC----------PGDL 1290
                               .:||.|.::          |:|.:.:|.|.|.          |.|.
  Fly   320 -------------------ATPMEQAYI----------GQRLARIPKDELYMVHRSPTKKPPSDQ 355

  Fly  1291 RRVTIDKRDKSLGITIQCNNNGGGIFVSTVADKSTAMRAGLQVGDQLLEVCGINMRAATQEIAAN 1355
            ...|..:....:.:.|..|:...|    .:||  |.:.|.|:...:     ...:...|.:..:|
  Fly   356 NPSTAYQEHNDIELYIDSNSRSSG----DLAD--TELEANLRRHSR-----NFTLSPETTDYDSN 409

  Fly  1356 VLRQCGDSFTMLVQYN-PEKFPSIEYEGAHNLEPESPINHSGSPTPRNSPRPPARNSLFPLPMQP 1419
                |||..::....| |..|..: |.....||......|: |.|..|.
  Fly   410 ----CGDLDSLSNDINCPTDFGKL-YTSMPVLEDGLSSGHA-SDTENNV---------------- 452

  Fly  1420 QAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPS 1484
                    |......||.:.|...:...|...:.:..::.|::..|.||.||.::.:.|....|.
  Fly   453 --------SVVCDKQQSSQSQPVHEHNGNGERLENDYNVMSASLATLTTDASQSALISDFASLPM 509

  Fly  1485 LP-PPPASVP----AETLRYVTLHMDKSKNLGIKLFGGNKVGIYVHDVAVGSPSDHAGIRKGDQI 1544
            .| |||:|.|    |:....:|:..|....|. ..:|.      |:..|:|..........|
  Fly   510 PPAPPPSSPPQIEIADASESMTMVPDADNPLD-SHYGA------VYAAALGGTHTEKSAGSG--- 564

  Fly  1545 LEYNGVDLSGVTAEQAANEISKLTDTVTMLVQNKLHTLKQIK--DE-----PGDSFYI-RVG--- 1598
            |....|...|....|||:||.:....:...:|......:::|  ||     |....:: |.|
  Fly   565 LGVTPVTAGGSLPSQAASEIQEAMKEIRSALQRAKTQPEKLKFCDEVLPTDPDSPVWVPRKGTTI 629

  Fly  1599 -----------------FDR-TGELNEDDLRFVKDEVLYVDNTVFNGT 1628
                             .|| .|:...|:..|..|:.| .||....||
  Fly   630 STAQGAAADEEPDTDLETDRLLGQQRHDEQDFFADQSL-ADNNANEGT 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	14/78 (18%)
		PDZ_signaling	1497..1576	CDD:238492	16/78 (21%)
		SH3_DLG5	1594..1657	CDD:212794	13/57 (23%)
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919
		PDZ_signaling	988..1065	CDD:238492
		PDZ_signaling	1092..1151	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810