Protein Alignment Dlg5 and Dlg1

DIOPT Version :9

• Sequence 1: NP_609505.1
• Gene: Dlg5 / 34573
• FlyBaseID: FBgn0032363
• Length: 1916
• Species: Drosophila melanogaster
• Sequence 2: XP_038943929.1
• Gene: Dlg1 / 25252
• RGDID: 2505
• Length: 939
• Species: Rattus norvegicus
• Alignment Length: 1081
• Identity: 249/1081 - (23%)
• Similarity: 405/1081 - (37%)
• Gaps: 332/1081 - (30%)

  Fly   954 PKNSSGSNMFMPLHPTRGSHPPPVGQPPDVVSLKSQN-SIESILSAKSPAISEYGMYAKRHVPQA 1017
            ||....|....|:.|         |.|.:..||.|.. :.||:....||.:.:| .|....|..:
  Rat    64 PKCVDHSKQCEPVQP---------GNPWESGSLSSAAVTSESLPGGLSPPVEKY-RYQDEEVLPS 118

  Fly  1018 VRHVPKYPSD---------SESIGSGVHGGYGGFLQSNHMPGNRHTQLFPTFGPGGRGNRRSSPL 1073
            .|..|:.|::         ||...|.:...: ||:..:|:...:.|:..|...|       ..|:
  Rat   119 ERISPQVPNEVLGPELVHVSEKSLSEIENVH-GFVSHSHISPIKPTEAVPPSSP-------IVPV 175

  Fly  1074 TLPSPPPQQQ---LQQLPAATAP-----HDSVGIP-----TDLDYHPHHHTQTNAMPHPHPHPHA 1125
            |...|.|.:.   |...|.|..|     .||:..|     ||.||.....|
  Rat   176 TPALPVPAESPVVLPSTPQANPPPVLVNTDSLETPTYVNGTDADYEYEEIT-------------- 226

  Fly  1126 PYLDYGH-GLGIGPYMGVGGGVSG---------------VGGAIYEGGTFPRKKDNQRLRIPSNP 1174
              |:.|: |||    ..:.||...               .|||..:.|         |||:  |.
  Rat   227 --LERGNSGLG----FSIAGGTDNPHIGDDSSIFITKIITGGAAAQDG---------RLRV--ND 274

  Fly  1175 SVASKSSSMVKN-----------SSGSIDHHYVTSTGPVSGGSMSASSSDRAPMSLMSSSIHNSY 1228
            .:...:.:.|::           .:|||...||....|.|...|....
  Rat   275 CILRVNEADVRDVTHSKAVEALKEAGSIVRLYVKRRKPASEKIMEIKL----------------- 322

  Fly  1229 GANIAGGNGTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSHGGGGSGKRNSNVPADFLCPGDLRRV 1293
               |.|..|.|.||                           .||.|  |.::|.|
  Rat   323 ---IKGPKGLGFSI---------------------------AGGVG--NQHIPGD---------- 345

  Fly  1294 TIDKRDKSLGITIQCNNNGGGIFVSTVADKSTAMRAG-LQVGDQLLEVCGINMRAATQEIAANVL 1357
                               ..|:|:.:.:...|.:.| ||:||:||.|..:.:...|.|.|...|
  Rat   346 -------------------NSIYVTKIIEGGAAHKDGKLQIGDKLLAVNSVCLEEVTHEEAVTAL 391

  Fly  1358 RQCGDSFTMLVQYNPEKFPSIEYEGAHNLEPESPINHSGSPTP--RNSPRPPARNSLFPLPMQPQ 1420
            :...|...:.|                 .:|.|...:.|...|  .||......|.:.|.....|
  Rat   392 KNTSDFVYLKV-----------------AKPTSMYINDGYAPPDITNSSSQSVDNHVSPSSYLGQ 439

  Fly  1421 APSTRPGSRAPLSHQSIKDQSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSL 1485
            .|:: |...:|:|...:.|...|                                   .||
  Rat   440 TPAS-PARYSPISKAVLGDDEIT-----------------------------------REP---- 464

  Fly  1486 PPPPASVPAETLRYVTLHMDKSKNLGIKLFGG-NKVGIYVHDVAVGSPSDHAG-IRKGDQILEYN 1548
                        |.|.||.. |..||..:.|| :..||::..:..|.|:|.:| :||||:|:..|
  Rat   465 ------------RKVVLHRG-STGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVN 516

  Fly  1549 GVDLSGVTAEQAANEISKLTDTVTMLVQ----------NKLHTLKQ-------------IKDEPG 1590
            .|||...:.||||..:......||::.|          .|:|.|::             ::....
  Rat   517 SVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSVSSGSGSLRTSQK 581

  Fly  1591 DSFYIRVGFD----RTGELNEDDLRFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHRKECGIIPS 1651
            .|.|:|..||    :...|....|.|...::|:|.|.   .....|:|.::...|...|.|:|||
  Rat   582 RSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINA---SDDEWWQARQVTPDGESDEVGVIPS 643

  Fly  1652 QMKVEEELRSG-EVVDCDTGTARRG------STSARRSFFRRK----KN-----QRSSSRDSTEI 1700
            :.:||::.|:. :.|..::.|  ||      :...:::.|.||    ||     |.:|..|....
  Rat   644 KRRVEKKERARLKTVKFNSKT--RGDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVT 706

  Fly  1701 ASFSNTQLSFFPDLGLLNDDGG---------ALSYQRVELLDSPIRRPVLIIGPLSECLMVRLTI 1756
            ::.|:::.|:   |.|:.|:.|         .|||:.|...:....|||:|:||:.:.:...|..
  Rat   707 SNASDSESSY---LILITDEYGCSKGGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRVNDDLIS 768

  Fly  1757 DFSNLFKLC-----------EVTAMD----CSQEAMEEGLKENIFVDYRRRGNKFECTTVEAISN 1806
            :|.:.|..|           ||...|    .|:|.||:.::|:.|::..:..|....|:|::: .
  Rat   769 EFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSV-R 832

  Fly  1807 ACKNDRRHCILDVSISAVERLQRLQIYPIVLLLRFKSAKQIRDIRDFGTDKISAKAAKEMYERAM 1871
            |.....:|||||||.:|::|||..|:|||.:.::.||.:.|.::....||    :.|::.:|||:
  Rat   833 AVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTD----EQARKTFERAV 893

  Fly  1872 KLETDYKQYISAVIPGVSIKHMCTQIKDAVDKEQDKLLWVP 1912
            :||.::.::.:|::.|.:::.:..|:|..::::....:|||
  Rat   894 RLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGPYIWVP 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	16/79 (20%)
		PDZ_signaling	1497..1576	CDD:238492	30/80 (38%)
		SH3_DLG5	1594..1657	CDD:212794	19/66 (29%)
		Guanylate_kin	1737..1904	CDD:279019	53/181 (29%)
		NK	<1773..1905	CDD:302627	40/131 (31%)
Dlg1	XP_038943929.1	PDZ_signaling	224..308	CDD:238492	21/114 (18%)
		PDZ_signaling	317..403	CDD:238492	30/180 (17%)
		PDZ_assoc	404..465	CDD:402299	17/112 (15%)
		PDZ	463..547	CDD:214570	33/100 (33%)
		SH3_DLG1	582..648	CDD:212964	19/68 (28%)
		Guanylate_kin	748..926	CDD:395500	53/182 (29%)
		L27_1	2..62	CDD:401120
		MAGUK_N_PEST	106..223	CDD:402306	30/125 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810