DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and sprt

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_610683.1	Gene:	sprt / 246397	FlyBaseID:	FBgn0082585	Length:	634	Species:	Drosophila melanogaster

Alignment Length:	750	Identity:	133/750 - (17%)
Similarity:	225/750 - (30%)	Gaps:	331/750 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 SKNVLSLTEELNQLLSEKDNVLQ--------------------EHQKMSDDLVLANKEIERLKKD 272
            |::..|.::||...|.:::.|:|                    |.:|.:     |.:::.|||.:
  Fly    80 SRSTRSESKELRSALQDREAVIQNLRIQLCLGKLPRPTGPPLDESEKPA-----AEQKLNRLKTE 139

  Fly   273 EQLARAEIKVLQLANADLKKRDLLKSRDSSWSKEFPSGKE----LENSKELEKLRKSLEKALSEV 333
            .:..|.:||.|:.|...|...|.:..|......|:..|:|    |...:|...|:..|||:..|.
  Fly   140 AENKRIKIKNLKSALEKLDITDNIDIRIRQAELEYALGREELQMLSIVEEARALQARLEKSKPEA 204

  Fly   334 E----------RSSQDAEEAKRVRDWAISQR--------------------EKIVQERDSVKTLC 368
            :          ..|..|..|...| ||:.||                    ::|::....:.|
  Fly   205 QTLYNIISSGVSLSLHAVHATSGR-WAVQQRTDQPGFYVEWALEGDGLYKGDRILEINGRLVT-- 266

  Fly   369 DKMRHERDKAISDS----LMAIR-----------DSEKIKKQK--------DEAQKKIDLLKE-- 408
            .|.:.|..|.:.:|    ::.:|           |.||....:        :|..:::..:||
  Fly   267 GKSKEELQKQVGNSGKCQMVVLRKKSVPIPQKQLDQEKENNMRLQHRISYLEEQVRELQTVKEHH 331

  Fly   409 -----QMEQQERQNLDSNASGSRRSFRPSSYEGEDLLEVELSGYEHTSDLGIILDDSNKRKLVCG 468
                 |.:||::||...|..                     ...:.||        ||:.:.|..
  Fly   332 PSQQQQQQQQQQQNPQQNPQ---------------------QNPQQTS--------SNQSQHVTS 367

  Fly   469 VTSSSPACGKLKINDVICKVNNLDCQSLSKRMVLDEIRACAPRSLLLVSRTRHSKRHAYSVQLKT 533
            ::.|||.                               :..|...|:..|
  Fly   368 ISISSPP-------------------------------STPPEKPLIFQR--------------- 386

  Fly   534 RDRDCPHGLQLDMGVFIAKIEQNSLAFYEPELDVGDRVLSINNKSMDSVQSIEEVMQLMNDPRSD 598
                         |.:|..:             ||.:.:.:....|.|.|:
  Fly   387 -------------GNYITTL-------------VGGKPIELMGDDMASTQT-------------- 411

  Fly   599 GLNLFALKYVQDQLPPGMTT-----SSAQTDSIDSMQHVSSAGGGGGSGPS---SATK------- 648
                          |||..|     .:...|..|.:.|:.|.       ||   ||:|
  Fly   412 --------------PPGHVTKTLIKENTHIDLRDRLSHMYSM-------PSKSLSASKISINSDS 455

  Fly   649 ----HPSRFAEFFFRKLKFSKPGTPEDNFEQEHDDAIAALDSVLSENSSEKSKENL-----FNRK 704
                |..|..|....:....:|..|....:|.|.:.:.        ::..:|.|:|     .:|:
  Fly   456 AYMQHHRRDKERHRDRQHRERPRDPLQQQQQLHREHLM--------STHARSVEHLNHYNGLDRR 512

  Fly   705 KRTKKEKEASKSMGTWPRTNISHENPTGTMRGN--EKKRALMSLFTAGPINVDKDDELMGEVGVP 767
            :.|.::.|::                  |:|..  ...|::.||        |.|.|       .
  Fly   513 RDTPRQSESN------------------TLRARLPSDMRSVKSL--------DFDSE-------N 544

  Fly   768 EKQPAALIQDQLPPPLPPQMSKPLAHIRGSNGGAIKTHP----------------NRNSN----- 811
            |.:||.  :.:...|.||:....|:..|..:...::.||                |.|:|
  Fly   545 ESKPAT--ETRTTRPTPPKKPLRLSLQRAQSLQTVELHPCADIERKRPMKRVHHNNNNNNKGGES 607

  Fly   812 PVSSGVSALFPPGPPNGMPNTSYPTHP----RHSL 842
            |...|.:.|        :.|.| |.|.    ||.|
  Fly   608 PTGEGQTML--------IENCS-PMHTASLGRHKL 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211	30/128 (23%)
		CENP-F_leu_zip	229..360	CDD:287450	39/184 (21%)
		DUF1090	<326..408	CDD:284007	23/134 (17%)
		PDZ_signaling	439..516	CDD:238492	10/76 (13%)
		PDZ_signaling	533..592	CDD:238492	7/58 (12%)
		PDZ_signaling	1290..1369	CDD:238492
		PDZ_signaling	1497..1576	CDD:238492
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
sprt	NP_610683.1	PDZ	<247..288	CDD:294084	6/42 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900