DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dlg5 and Magi3

DIOPT Version :9

Sequence 1:NP_609505.1 Gene:Dlg5 / 34573 FlyBaseID:FBgn0032363 Length:1916 Species:Drosophila melanogaster
Sequence 2:NP_620784.3 Gene:Magi3 / 245903 RGDID:621362 Length:1470 Species:Rattus norvegicus


Alignment Length:1517 Identity:302/1517 - (19%)
Similarity:488/1517 - (32%) Gaps:494/1517 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   467 CGVTSSSPACGKLKINDVICKVNNLDCQSLSKRMVLDEIRACAPRSLLLVSRTRHSK------RH 525
            |.|:..:|:.|     ||:.:||......|:.|..|..||..  |..:.:...:..|      ||
  Rat    60 CVVSGKAPSPG-----DVLLEVNGTPVSGLTNRDTLAVIRHF--REPIRLKTVKPGKVINKDLRH 117

  Fly   526 AYSVQLKTRDRDCPHGLQ--LDMGVFIAKIEQNSLAFYEPELDVGDRVLSINNKSMDSVQSIEEV 588
            ..|:|.:....|  |.||  :...:::..|...:.|..:.|:...|    .|..|::..:::||.
  Rat   118 YLSLQFQKGSID--HKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVD----YNFISVEQFKALEES 176

  Fly   589 MQLMNDPRSDGLNLFALKYVQDQLPPGMTTSSAQTDSIDSMQHVSSAGGGGGSGPSSATKHPSRF 653
            ..|:.....|| |.:...      .|....|..|.|.:|.:.                       
  Rat   177 GALLESGTYDG-NFYGTP------KPPAEPSPFQPDPVDQVL----------------------- 211

  Fly   654 AEFFFRKLKFSKPGTPEDNFEQEHD-----------DAIAALDSVLSENSSEKSKENLFNRKKRT 707
                               |:.|.|           ..:..:||.|.|...::.||.: |.....
  Rat   212 -------------------FDNEFDTESQRKRTTSVSKMERMDSSLPEEEEDEDKEAV-NGSGSM 256

  Fly   708 KKEKEASKSMGTWPRTNISHENPTGTMRGNEKKRALMSLFTAGPINVDKDDELMGEVGVPEKQPA 772
            :..:..|:|...|.:|..|:..   |.|..:.:..:|           :|:.|            
  Rat   257 ETREMHSESSDCWMKTVPSYNQ---TNRSMDFRNYMM-----------RDENL------------ 295

  Fly   773 ALIQDQLPPPLPPQMSKPLAHIRGSNGGAIK--THPNRNSNPVSSGV--SALFPPGPPNG-MP-N 831
                    .|||....  :|:   ::.|.|.  .|..:.:..:...:  .|..|....:| :| .
  Rat   296 --------EPLPKNWE--MAY---TDTGTIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYG 347

  Fly   832 TSYPTHPRHSLYGVTAEEINQKPIQRAPLMGANARVKMPSQERYGTRPHSNHRLSLNITPSGDFY 896
            ......|::..|.|  :.:|||.....|:..|..:.::...|.:..:. ...|......||    
  Rat   348 WEKIEDPQYGTYYV--DHLNQKTQFENPVEEAKRKKQIGQAETHSAKT-DVERAHFTRDPS---- 405

  Fly   897 QPKTSGQQAQQQVMNAS--STSAGFGVGSGSMVGG--------------TGPAA-------GEFP 938
                   |.:..::.||  .::.|||.   :::||              .||||       |:..
  Rat   406 -------QLKGVLVRASLKKSTMGFGF---TIIGGDRPDEFLQVKNVLKDGPAAQDGKMAPGDVI 460

  Fly   939 V----------RKQQVYDVFHPPPLPKNSSGSNMFMPLHPTRGSHPPPVGQPP--DVVSLKSQNS 991
            |          ....|..:|...|:       |.::.|...||...|...:.|  |:|       
  Rat   461 VDINGNCVLGHTHADVVQMFQLVPV-------NQYVNLTLCRGYALPDDSEDPVVDIV------- 511

  Fly   992 IESILSAKSPAISEYGMYAKRHVPQAVRHVPKYPSDSESIGSGV---HGGYGGFLQSNHMPGNRH 1053
                  |.:|.|:...: ||.....:.:..        .:|:.|   :|..|..|.|:|:.    
  Rat   512 ------AATPVINGQSL-AKGEACMSTQDF--------KLGAMVLDQNGKSGKLLSSDHLN---- 557

  Fly  1054 TQLFPTFGPGGRGNRRSSPLTLPSPPPQQQLQQLPAATAPH-------DSVGIPTD------LDY 1105
                   ||.....:|:|..:..|..|  :|..:|....|.       ||   ||.      ||.
  Rat   558 -------GPSDSNEQRASLASSGSSQP--ELVTIPLVKGPKGFGFAIADS---PTGQKVKMILDS 610

  Fly  1106 HPHHHTQTNAMPHPHPHPHAPYLDYGHGLGIGPYMGVGGGVSGVGGAIYEGGTFPRKKDNQRLRI 1170
            ......|...:.....|.:...|.:...:.:.....||..|..:   |..||             
  Rat   611 QWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLL---ILRGG------------- 659

  Fly  1171 PSNPSVASKSSSMVKNSSGSIDHHYVTSTGP-------VSGGSMSASSS-----------DRAP- 1216
            |.:|:..:|..:..|.:|||::.....:..|       :..||.....|           |:.| 
  Rat   660 PCSPTKTAKMKTDTKETSGSLETINEPTPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPN 724

  Fly  1217 ---MSLMSSSIHNSYGANIAGGNGTGSSIGVGG----GGGGGSGR-----------GSPMP-QVH 1262
               :.:......:.:|..:.||:|...||.:|.    |.....||           |.|:. :.|
  Rat   725 TKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSH 789

  Fly  1263 VEVL------SHGGG-----------GSGKRNSNVPADFLCPGD--LRRVTIDKR---DKSLGIT 1305
            .:||      :..|.           |..:.....|..|...|.  |.|..:..|   .:|..:.
  Rat   790 KQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDESPQAFSQSGSPRLNRTELPTRSAPQESYDVI 854

  Fly  1306 IQCNNNGGGIFV-----------------STVADKSTAMRAG-LQVGDQLLEVCGINMRAATQEI 1352
            :|...|.|..||                 ..|.|.|.|.|.| |:|||.:..|.|.::...:.:.
  Rat   855 LQRKENEGFGFVILTSKSKPPPGVIPHKIGRVIDGSPADRCGRLKVGDHISAVNGQSIVDLSHDN 919

  Fly  1353 AANVLRQCGDSFTMLVQYNPEKFPSIEYEGAHNLEPESPINHSGSPTPRNSPR-PPARNSLFPLP 1416
            ...:::..|.:.|:.|....|                    |.|.|:..||.| .||   |...|
  Rat   920 IVQLIKDAGVTVTLTVVAEEE--------------------HHGPPSGTNSARQSPA---LQHRP 961

  Fly  1417 MQPQAPSTR-PGSRAPLSHQSIKD--QSFTDSLENQSDISSSQDMPSSAATTTTTTASATSTVYD 1478
            | .||.:|. ||.|..|..:..||  .|:..|..:...::    .|.:|..:...:..:.|.   
  Rat   962 M-GQAQATHIPGDRTALEGEVGKDVCSSYRHSWSDHKHLA----QPDTAVISVVGSRHSQSL--- 1018

  Fly  1479 EEPKPSLPPPPASVPAETLRYVTLHMDKSKNLGIKLFGGNK--VGIYVHDVAVGSPSDHAG-IRK 1540
                       ...|.|..|       ..:..|..|.||.:  :|:::..:|...|:...| |..
  Rat  1019 -----------GCYPVELER-------GPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHV 1065

  Fly  1541 GDQILEYNGVDLSGVTAEQAANEISKLTDTVTMLVQNKLHTLKQ--------------IKDE--- 1588
            ||||:|.||....|:|..:|...|....:.|.:|::.....:..              |.||   
  Rat  1066 GDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDHGDWDIYSPSSSNVIYDEQPP 1130

  Fly  1589 PGDSFYIRVGFDRTG-ELNEDDL---------RFVKDEVLYVDNTVFNGTFGLWRAWKLDAMGHR 1643
            |..|.:....|:.:. .:.||.|         ..:||.|....:|: ||:....:...:.....:
  Rat  1131 PLPSSHSAATFEESHVPVTEDSLIRVQTCEKAEELKDTVQEKKSTL-NGSQPEMKYQSVQKNVSK 1194

  Fly  1644 KECGIIPSQM--KVEEELRSGEVVDCDTGTARRG-STSARRSFFR-------------------- 1685
            |:    ||:.  ..::.|..||     .|..||| |.|.::|..|                    
  Rat  1195 KD----PSRSHGHGDKNLPKGE-----NGVTRRGRSASPKKSVNRHSEEHLEKIPRPLRSDPKGK 1250

  Fly  1686 ----------------------------RKKNQRSSS-RDSTEIA--SFSNTQLSFFPDLGLLND 1719
                                        ||...|||| |...:|.  |.|||:       |.|::
  Rat  1251 SRDRSLSPRKGENKGQVTIKAGSGQDPCRKDRGRSSSPRKQQKIGGNSLSNTE-------GKLSE 1308

  Fly  1720 DGGALSYQRVELL--DSPIRRP 1739
            .|.    :|...|  |||.:.|
  Rat  1309 AGS----RRAAGLSSDSPEQLP 1326

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dlg5NP_609505.1 AAA_23 <165..333 CDD:290211
CENP-F_leu_zip 229..360 CDD:287450
DUF1090 <326..408 CDD:284007
PDZ_signaling 439..516 CDD:238492 14/48 (29%)
PDZ_signaling 533..592 CDD:238492 12/60 (20%)
PDZ_signaling 1290..1369 CDD:238492 23/99 (23%)
PDZ_signaling 1497..1576 CDD:238492 23/81 (28%)
SH3_DLG5 1594..1657 CDD:212794 13/74 (18%)
Guanylate_kin 1737..1904 CDD:279019 1/3 (33%)
NK <1773..1905 CDD:302627
Magi3NP_620784.3 Interaction with ADRB1 and TGFA. /evidence=ECO:0000269|PubMed:16316992 18..108 14/54 (26%)
PDZ_signaling 24..103 CDD:238492 14/49 (29%)
NK 125..>199 CDD:418433 17/86 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 184..266 19/131 (15%)
HUL4 <211..>373 CDD:227354 37/245 (15%)
WW 299..329 CDD:238122 5/34 (15%)
WW 345..375 CDD:238122 8/31 (26%)
Interaction with PTEN. /evidence=ECO:0000250 413..495 18/91 (20%)
PDZ 416..496 CDD:214570 16/89 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 550..575 7/35 (20%)
PDZ 578..659 CDD:214570 16/86 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 665..700 6/34 (18%)
PDZ 729..812 CDD:214570 16/82 (20%)
Interaction with ADGRB1. /evidence=ECO:0000250 729..811 16/81 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..847 6/28 (21%)
PDZ_signaling 851..936 CDD:238492 19/84 (23%)
Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250 852..939 20/86 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..976 18/60 (30%)
PDZ_signaling 1023..1101 CDD:238492 24/84 (29%)
PTZ00112 1115..>1405 CDD:240274 50/233 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1124..1146 6/21 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1167..1470 40/181 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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