DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dlg5 and GRIP1

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	XP_016874587.1	Gene:	GRIP1 / 23426	HGNCID:	18708	Length:	1188	Species:	Homo sapiens

Alignment Length:	1511	Identity:	292/1511 - (19%)
Similarity:	467/1511 - (30%)	Gaps:	519/1511 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 SKNVLSLTEELNQLLSEKDNVLQEHQKM-----------SDDLVLANKEIERLKKDEQLARAEIK 281
            |::.|..|..||.:....|..:|..:|:           .||..| |.|...:.....|.::.::
Human    23 SESYLPATLILNSISFNTDGSIQYKEKLYFSASEALDAYIDDFHL-NYEPPDIDTKVNLDQSPLE 86

  Fly   282 VLQLANADLKKRDLLKSRDSSWSKEF-----PSG----------KELENSKELEKLRKSLEKALS 331
            .|..:|:|          :|.::|..     |.|          :|.:.|..:|.::|. ...|.
Human    87 FLAKSNSD----------ESPYTKSASQTKPPDGALAVRRQSIPEEFKGSTVVELMKKE-GTTLG 140

  Fly   332 EVERSSQDAEEAKRV---RDWAISQREKIVQERDSVKTLCDKMRHERDKAISDSLMAIRDSEKIK 393
            .......|.:...||   |...|:.|.             |::      .:.|.:.|:......|
Human   141 LTVSGGIDKDGKPRVSNLRQGGIAARS-------------DQL------DVGDYIKAVNGINLAK 186

  Fly   394 KQKDEAQKKIDLLK---EQMEQQERQNLDSNASGSRRSFRPSSYEGEDLL--EVELSGYEHTSDL 453
            .:.||.   |.|||   |::..:....|.           |.|.:|..::  .||::.::..:..
Human   187 FRHDEI---ISLLKNVGERVVLEVEYELP-----------PVSVQGSSVIFRTVEVTLHKEGNTF 237

  Fly   454 GIIL-----DDSNKRK---LVCGVTSSSPAC--GKLKINDVICKVNNLDCQSLSKRMVLDEIRAC 508
            |.::     ||.||.:   :.| |....||.  |.:|..|.:..|:.:.....:....:..::.|
Human   238 GFVIRGGAHDDRNKSRPVVITC-VRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQC 301

  Fly   509 APRSLLLVSRTRHSKRHAYSVQL----------------KTRDRDCPHGLQLDM-----GVFIAK 552
            ...:.||:.         |.|.:                ||........|...|     .:.|.|
Human   302 GQEAALLIE---------YDVSVMDSVATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDK 357

  Fly   553 IEQNSLAFYEPELDVGDRVLSINNKSMDSVQSIEEVMQLMNDPRSDGLNLFALKYVQDQLP---P 614
            |:..|:|.....|.|||.:|||:..||:.....|....|.|  .:|.:.|..|.:.|.:|.   |
Human   358 IKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLAN--TTDQVKLEILPHHQTRLALKGP 420

  Fly   615 G----------MTTSS--AQTDSIDSMQHVSSAGGGGGSGPSSATKHPS--RFAEFFFRKLKFSK 665
            .          :|..|  :...|:.:..|.:             |.||.  |.....|.|.  ..
Human   421 DHVKIQRSDRQLTWDSWASNHSSLHTNHHYN-------------TYHPDHCRVPALTFPKA--PP 470

  Fly   666 PGTPEDNFEQEHDDAIAALDSVLSENSSEKSKENLFNRKKRTKKEKEASKSMGTWPRTNISHENP 730
            |.:|.           |.:.|..|..|  .|..:|            :|.:|||.||:..| .:|
Human   471 PNSPP-----------ALVSSSFSPTS--MSAYSL------------SSLNMGTLPRSLYS-TSP 509

  Fly   731 TGT-MRGNEKKRALMSLFTAGPINVDKDDELMGEVGVPEKQPAALIQDQLPPPLPPQMSKPLAHI 794
            .|| ||...||:...|..:.....|.    |.|:|...|.....|..|            |:...
Human   510 RGTMMRRRLKKKDFKSSLSLASSTVG----LAGQVVHTETTEVVLTAD------------PVTGF 558

  Fly   795 RGSNGGAIKTHPNRNSNPVSSGVSALFPPGPPNGMPNTSYPTHPRHSLYGVTAEEINQKPIQRAP 859
            .....|::......:|.|:.|.:.|                                ..|.:|..
Human   559 GIQLQGSVFATETLSSPPLISYIEA--------------------------------DSPAERCG 591

  Fly   860 LMGANARVKMPSQERYGTRPHSNHRLSLNITPSGDFYQPKTSGQQAQQQVMNASSTS-----AGF 919
            ::....||                 :::|..|:.|     ::.::|.|.:.::|.||     ..|
Human   592 VLQIGDRV-----------------MAINGIPTED-----STFEEASQLLRDSSITSKVTLEIEF 634

  Fly   920 GVGSGSMVGGTGPAAGEFPVRKQQVYDVFHPPPLPKNSS---GSNMFMPLHPTRGSHPPPVGQPP 981
            .|....:     |::|.|.|:            |||..:   |..:..|     .|..|  |.|.
Human   635 DVAESVI-----PSSGTFHVK------------LPKKHNVELGITISSP-----SSRKP--GDPL 675

  Fly   982 DVVSLKSQNSI----------ESILSAKSPAISEYGMYAKRHVPQAVRHVPKY--------PSDS 1028
            .:..:| :.|:          :.:|:..:..:....|.....:.|....:.|.        ..:.
Human   676 VISDIK-KGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQ 739

  Fly  1029 ESIGSGVH----GGYGGFLQSNHMPGNRHTQLFPTFGP--------GGRGNRRSS------PLTL 1075
            ||.|:.::    ..|||.|      |...:.....|.|        ||...|..:      .|.:
Human   740 ESSGAIIYTVELKRYGGPL------GITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAI 798

  Fly  1076 PSPPPQQQLQQLPAATAPH--DSVGIPTDLDYHPHHHTQTNAMPHPHPHPHAPYLDYGHGLGIGP 1138
            .|    ..|:..|.:.|.|  ...|....|........|:.:.|...|
Human   799 NS----SSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSPKKFP----------------- 842

  Fly  1139 YMGVGGGVSGVGGAIYEGGTFPRKKDNQRLRIPSNPSVASKSSSMVKNSSGSIDHHYVTSTGPVS 1203
               :...:|.:|.                  :..:.|.|.|        .|.:...| .||.|
Human   843 ---ISSHLSDLGD------------------VEEDSSPAQK--------PGKLSDMY-PSTVP-- 875

  Fly  1204 GGSMSASSSDRAPMSLMSSSIHNSYGANIAGGNGTGSSIGVGGGGGGGSGRGSPMPQVHVEVLSH 1268
                   |.|.|..|...|:|..|||..       |:|....|
Human   876 -------SVDSAVDSWDGSAIDTSYGTQ-------GTSFQASG---------------------- 904

  Fly  1269 GGGGSGKRNSNVPADFLCP---GDLRRVTIDKRD--KSLGITIQCNNNGGGIFVSTVADKSTAMR 1328
                   .|.|. .|:..|   |.|..||..:..  ..:|::.:            ..|:|||
Human   905 -------YNFNT-YDWRSPKQRGSLSPVTKPRSQTYPDVGLSYE------------DWDRSTA-- 947

  Fly  1329 AGLQVGDQLLEVCGINMRAATQE------IAANVLRQCGDSFTMLVQYNPEKFPSIEYEGAHNLE 1387
            :|.         .|....|.|::      .|...|..||.|..:.           |.|......
Human   948 SGF---------AGAADSAETEQEENFWSQALEDLETCGQSGILR-----------ELEATIMSG 992

  Fly  1388 PESPINHSGSPTPRNSPRPPARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDSLENQSDI 1452
            ....:||. :||||:.   ..|.:.|     .:..|:||                     :.|..
Human   993 STMSLNHE-APTPRSQ---LGRQASF-----QERSSSRP---------------------HYSQT 1027

  Fly  1453 SSSQDMPSSAATTTTTTASATSTVYDEEPKPSLPPPPASVPAETLRYVTLHMDKS-KNLGIKLFG 1516
            :.|..:||...     ..|.|.....:|.|..:.|.|..     |..|||:.|.. ::.|..:..
Human  1028 TRSNTLPSDVG-----RKSVTLRKMKQEIKEIMSPTPVE-----LHKVTLYKDSDMEDFGFSVAD 1082

  Fly  1517 G-NKVGIYVHDVAVGSPSDHAGIRKGDQILEYNGV---DLSGVTAEQAANEISKLTDTVTMLVQN 1577
            | .:.|:||.::....|.|..|::..|::|:.|.|   |...........|.....|.|  :.:|
Human  1083 GLLEKGVYVKNIRPAGPGDLGGLKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDLV--ISRN 1145

  Fly  1578 KLHTLKQIKDE--PGD 1591
            .|.:.|.|..:  |||
Human  1146 PLASQKSIDQQSLPGD 1161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211	26/130 (20%)
		CENP-F_leu_zip	229..360	CDD:287450	31/159 (19%)
		DUF1090	<326..408	CDD:284007	17/87 (20%)
		PDZ_signaling	439..516	CDD:238492	17/88 (19%)
		PDZ_signaling	533..592	CDD:238492	18/63 (29%)
		PDZ_signaling	1290..1369	CDD:238492	17/86 (20%)
		PDZ_signaling	1497..1576	CDD:238492	21/83 (25%)
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
GRIP1	XP_016874587.1	PDZ_signaling	128..208	CDD:238492	20/102 (20%)
		PDZ_signaling	227..310	CDD:238492	17/83 (20%)
		PDZ_signaling	325..408	CDD:238492	23/84 (27%)
		PDZ_signaling	545..633	CDD:238492	20/153 (13%)
		PDZ_signaling	646..730	CDD:238492	17/103 (17%)
		PDZ_signaling	746..827	CDD:238492	18/90 (20%)
		PDZ_signaling	1062..1142	CDD:238492	21/81 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900