DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dlg5 and Cytip

DIOPT Version :9

Sequence 1:NP_609505.1 Gene:Dlg5 / 34573 FlyBaseID:FBgn0032363 Length:1916 Species:Drosophila melanogaster
Sequence 2:NP_631939.1 Gene:Cytip / 227929 MGIID:2183535 Length:359 Species:Mus musculus


Alignment Length:296 Identity:69/296 - (23%)
Similarity:106/296 - (35%) Gaps:80/296 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   465 LVCGVTSSSPA-CGKLKINDVICKVNNLDCQSLSKRMVLDEIRACAPRSLLLV---SRTRHSKRH 525
            ::|.|...||| |..|::.|:...||.:..:..:.:.|:|.||:..  :||.:   :.|...:|.
Mouse   110 MICKVQEDSPAHCAGLQVGDIFANVNGVSTEGFTHKQVVDLIRSSG--NLLTIETLNGTMIHRRA 172

  Fly   526 AYSVQLKTRDRDCPHGLQLDMGVFIAKIEQNSLAFYEPELDVGDRVLSINNKSMDSVQSIEEVMQ 590
            ....:|:|          |...:....:|..||...|..|..||...|.|.::||..:|      
Mouse   173 ELEAKLQT----------LKQTLKKKWVELRSLHLQEQRLLHGDTANSPNLENMDLDES------ 221

  Fly   591 LMNDPRSDGLNLFALKYVQDQLPPGMTTSSAQTDSIDSMQHVSSAGGGGGSGPSSAT-----KHP 650
                      :||.     :.|.|    |.|..|     :|..|:.....|..||.|     .:.
Mouse   222 ----------SLFG-----NLLGP----SPALLD-----RHRLSSESSCKSWLSSLTVDSEDGYR 262

  Fly   651 SRFAEFFFRKLKFSKPGTPEDNFEQEHDDAIAALDSVLSENSSEKSKENLFNRKKRTKK------ 709
            |..:|...|. .||:..:.:|......|.     |.:|...||.:      ||......      
Mouse   263 SSMSEDSIRG-AFSRQTSTDDECFHSKDG-----DEILRNASSRR------NRSISVTSSGSFSP 315

  Fly   710 --EKEASKSMGTWPRTNISHENPTGTMRGNEKKRAL 743
              |...|...||.||.         :.||:.:|:.|
Mouse   316 LWESNYSSVFGTLPRK---------SRRGSVRKQIL 342

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dlg5NP_609505.1 AAA_23 <165..333 CDD:290211
CENP-F_leu_zip 229..360 CDD:287450
DUF1090 <326..408 CDD:284007
PDZ_signaling 439..516 CDD:238492 16/51 (31%)
PDZ_signaling 533..592 CDD:238492 14/58 (24%)
PDZ_signaling 1290..1369 CDD:238492
PDZ_signaling 1497..1576 CDD:238492
SH3_DLG5 1594..1657 CDD:212794
Guanylate_kin 1737..1904 CDD:279019
NK <1773..1905 CDD:302627
CytipNP_631939.1 PDZ_signaling 76..161 CDD:238492 16/52 (31%)
Interaction with CYTH1. /evidence=ECO:0000250 166..188 5/31 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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