DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dlg5 and LNX2

DIOPT Version :9

Sequence 1:NP_609505.1 Gene:Dlg5 / 34573 FlyBaseID:FBgn0032363 Length:1916 Species:Drosophila melanogaster
Sequence 2:NP_699202.1 Gene:LNX2 / 222484 HGNCID:20421 Length:690 Species:Homo sapiens


Alignment Length:602 Identity:111/602 - (18%)
Similarity:203/602 - (33%) Gaps:191/602 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1170 IPSNPSVASKSSSMVKNSSGSIDHHYVTSTGPVSGGSMSASSSDRAPMSL-----MSSSIHNS-- 1227
            :|....:.|.|.|......|..:..:..|.|         :.:.:.|:||     .:..||.|  
Human   186 VPVERHLTSASLSTWSEEPGLDNPAFEESAG---------ADTTQQPLSLPEGEITTIEIHRSNP 241

  Fly  1228 ---YGANIAGGNGTGSSIGV------GGGGGGGSGR---------------------------GS 1256
               .|.:|.|||.| ..|.:      ..|.....||                           ..
Human   242 YIQLGISIVGGNET-PLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQ 305

  Fly  1257 PMPQVHVEVLSHGGGGSGKRN---SNVPADFLCPGDLRRVTIDKRD--KSLGITIQCNNNGGGIF 1316
            |...:|:.||.....|:...|   ||.|.:     ::.:|.:.|||  :.|||.:....:..|:|
Human   306 PCNTLHLTVLRERRFGNRAHNHSDSNSPRE-----EIFQVALHKRDSGEQLGIKLVRRTDEPGVF 365

  Fly  1317 VSTVADKSTAMRAG-LQVGDQLLEVCGINMRAATQEIAANVLRQCGDSFTMLVQYNPEKFPSIEY 1380
            :..:.:...|.:.| |...|::|.:.|.:::..|.|:||.:::..|:...:              
Human   366 ILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNL-------------- 416

  Fly  1381 EGAHNLEPESPINHSGSPTPRNSPRPPARNSLFPLPMQPQAPSTRPGSRAPLSHQSIKDQSFTDS 1445
                      .|...|.|.|.|:.|....:|.......|....:||                   
Human   417 ----------TIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRP------------------- 452

  Fly  1446 LENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSLPPPPASVPAETLRYVTLHMDKSKNL 1510
                   ||.:|:              |..|..:|                 :::|:..:..::|
Human   453 -------SSHKDL--------------TQCVTCQE-----------------KHITVKKEPHESL 479

  Fly  1511 GIKLFG--GNKVG---IYVHDVAV-GSPSDHAGIRKGDQILEYNGVDLSGVTAEQA-----ANEI 1564
            |:.:.|  |:|.|   |:|..|.. |..:....|::||.:|..||:||:.::..:|     |:..
Human   480 GMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAA 544

  Fly  1565 SKLTDTVTMLVQNKLHTLKQIKDEPGDSFYIRVGFDRTGELNEDDLRFVKDEVLYV--------- 1620
            |.......:.||......:..:::|.           |...||.|..:....|:::         
Human   545 SPAVALKALEVQIVEEATQNAEEQPS-----------TFSENEYDASWSPSWVMWLGLPSTLHSC 598

  Fly  1621 -DNTVFNGTFGLWRAWKLDAMGHRKE----------CGIIPSQMKVEEELRSGEVVDCDTGTARR 1674
             |..:.....|   :|....:|..:|          ..::.:....:..|:.|:::....|.:..
Human   599 HDIVLRRSYLG---SWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTV 660

  Fly  1675 G-STSARRSFFRRKKNQ 1690
            | |.||.....:.::|:
Human   661 GMSHSALVPMLKEQRNK 677

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dlg5NP_609505.1 AAA_23 <165..333 CDD:290211
CENP-F_leu_zip 229..360 CDD:287450
DUF1090 <326..408 CDD:284007
PDZ_signaling 439..516 CDD:238492
PDZ_signaling 533..592 CDD:238492
PDZ_signaling 1290..1369 CDD:238492 20/81 (25%)
PDZ_signaling 1497..1576 CDD:238492 22/89 (25%)
SH3_DLG5 1594..1657 CDD:212794 10/82 (12%)
Guanylate_kin 1737..1904 CDD:279019
NK <1773..1905 CDD:302627
LNX2NP_699202.1 mRING-HC-C3HC3D_LNX2 45..89 CDD:319694
modified RING-HC finger (C3HC3D-type) 50..87 CDD:319694
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..224 4/34 (12%)
NPXY motif 208..211 0/2 (0%)
PDZ 230..316 CDD:214570 16/86 (19%)
PDZ 336..422 CDD:214570 21/109 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 418..455 11/62 (18%)
PDZ_signaling 466..542 CDD:238492 21/92 (23%)
PDZ_signaling 599..683 CDD:238492 13/82 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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