DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dlg5 and T19B10.5

DIOPT Version :9

Sequence 1:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster
Sequence 2:	NP_505852.3	Gene:	T19B10.5 / 179553	WormBaseID:	WBGene00011833	Length:	596	Species:	Caenorhabditis elegans

Alignment Length:	434	Identity:	88/434 - (20%)
Similarity:	136/434 - (31%)	Gaps:	157/434 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1290 LRRVTIDKRDKSLGITIQCNNNGGGIFVSTVADKSTAMRAG-LQVGDQLLEVCGINMRAATQEIA 1353
            ||.|.|.    .||..||.|.| .||||..:..|..|.:.| :.|||::..:. ||......|.|
Worm   131 LRGVDIG----GLGFNIQGNMN-EGIFVKEIISKGIAEQCGNILVGDKIKSLT-INFENMVYEDA 189

  Fly  1354 ANVL-------------RQCGDSFTML---------------------VQYN------------- 1371
            ..:|             |:..||.::.                     |.:|
Worm   190 VTLLSYSSPYKVKLELERKLSDSASVSDSDDDKEMRYHPLFRSNTLTHVHFNPLGTISTPTSIAT 254

  Fly  1372 -PEKFPSIEYEGAHNLEPESPINHSGSPTPRN--------------------------------- 1402
             |::..|.:.:..|.|.|:..|....|.|..:
Worm   255 TPQRCTSTDSKQKHALPPQREIIEPDSTTCADDNSQARDADNSRMDSSDYGSDGISDCRESTASD 319

  Fly  1403 ---------------------SPRPPARNSL---FPLPMQPQAPSTRPGSRAPLSHQSIKDQSFT 1443
                                 ||.||....|   ..||.:|:...:|..|.......|.|....|
Worm   320 GTQKTLSDRIEVTDIIFDKVKSPTPPPLRKLEQCTELPPKPRKMVSRSPSPVNKPPPSPKVSRAT 384

  Fly  1444 DSLENQSDISSSQDMPSSAATTTTTTASATSTVYDEEPKPSLPPPPASVPAETLRYVTLHMDKSK 1508
            ...::|....|:|....||.|..|.|         |:|...:|||.:|:|      |...|:...
Worm   385 SPKKSQQVEDSTQTTQLSAETRPTQT---------EKPIAPVPPPISSIP------VRKEMETQT 434

  Fly  1509 NLGIKLFGGNKVGIYVHDVAVGSPSDHAGIRKGDQI--LEYNGVDLSGVTAEQA-ANEISKLTDT 1570
            ..                    .|.|...:.|..:|  :|....|..|....:| .:.|.|.:|:
Worm   435 KT--------------------PPPDQTVVEKIVEIAPVEIKEDDSKGPEITEARISRIPKRSDS 479

  Fly  1571 V-TMLVQNKLHTL-KQIKD-----EPGDSFYIRVGFDRTGELNE 1607
            : |.:::.||.:| |.:..     :..|:.:.|:..::.|.|.:
Worm   480 IKTPVIERKLPSLPKSVTQRSHSADKNDNVWSRLYQEKKGNLRK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007
		PDZ_signaling	439..516	CDD:238492
		PDZ_signaling	533..592	CDD:238492
		PDZ_signaling	1290..1369	CDD:238492	28/113 (25%)
		PDZ_signaling	1497..1576	CDD:238492	14/82 (17%)
		SH3_DLG5	1594..1657	CDD:212794	3/14 (21%)
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
T19B10.5	NP_505852.3	PDZ	137..208	CDD:214570	21/76 (28%)
T19B10.5	NP_505852.3	PTZ00449	<340..483	CDD:185628	41/177 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900